The Role of N^(6)-methyladenosine Modification in Gametogenesis and Embryogenesis:Impact on Fertility  

作　　者：Yujie Wang Chen Yang Hanxiao Sun Hui Jiang Pin Zhang Yue Huang Zhenran Liu Yaru Yu Zuying Xu Huifen Xiang Chengqi Yi 

机构地区：[1]Department of Obstetrics and Gynecology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China [2]NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract(Anhui Medical University),Hefei 230032,China [3]MOE Key Laboratory of Population Health Across Life Cycle(Anhui Medical University),Hefei 230032,China [4]State Key Laboratory of Protein and Plant Gene Research,School of Life Sciences,Peking University,Beijing 100871,China [5]Department of Interventional Therapy,the Second Affiliated Hospital of Anhui Medical University,Hefei 230601,China [6]Peking-Tsinghua Center for Life Sciences,Peking University,Beijing 100871,China [7]Department of Chemical Biology and Synthetic and Functional Biomolecules Center,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China

出　　处：《Genomics, Proteomics & Bioinformatics》2024年第4期31-46,共16页基因组蛋白质组与生物信息学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant No.82071614 to Huifen Xiang and Grant No.82101783 to Zuying Xu);the National Key R&D Program of China(Grant No.2021YFC2700600);the Anhui Medical University School Fund(Grant No.2020xkj182)。

摘　　要：The most common epigenetic modification of messenger RNAs(mRNAs)is N^(6)-methyladenosine(m^(6)A),which is mainly located near the 30 untranslated region of mRNAs,near the stop codons,and within internal exons.The biological effect of m^(6)A is dynamically modulated by methyltransferases(writers),demethylases(erasers),and m^(6)A-binding proteins(readers).By controlling post-transcriptional gene expression,m^(6)A has a significant impact on numerous biological functions,including RNA transcription,translation,splicing,transport,and degradation.Hence,m^(6)A influences various physiological and pathological processes,such as spermatogenesis,oogenesis,embryogenesis,placental function,and human reproductive system diseases.During gametogenesis and embryogenesis,genetic material undergoes significant changes,including epigenomic modifications such as m^(6)A.From spermatogenesis and oogenesis to the formation of an oosperm and early embryogenesis,m^(6)A changes occur at every step.m^(6)A abnormalities can lead to gamete abnormalities,developmental delays,impaired fertilization,and maternal-to-zygotic transition blockage.Both mice and humans with abnormal m^(6)A modifications exhibit impaired fertility.In this review,we discuss the dynamic biological effects of m^(6)A and its regulators on gamete and embryonic development and review the possible mechanisms of infertility caused by m^(6)A changes.We also discuss the drugs currently used to manipulate m^(6)A and provide prospects for the prevention and treatment of infertility at the epigenetic level.

关 键 词：SPERMATOGENESIS OOGENESIS EPIGENETICS N^(6)-methyladenosine Reproduction 

分 类 号：Q78[生物学—分子生物学]