Duodenal-jejunal bypass reduces serum ceramides via inhibiting intestinal bile acid-farnesoid X receptor pathway  

作　　者：Zhi-Qiang Cheng Tong-Ming Liu Peng-Fei Ren Chang Chen Yan-Lei Wang Yong Dai Xiang Zhang 

机构地区：[1]Department of General Surgery,Qilu Hospital of Shandong University,Jinan 250012,Shandong Province,China [2]Department of Colorectal and Anal Surgery,Feicheng Hospital Affiliated to Shandong First Medical University,Feicheng 271600,Shandong Province,China [3]Department of General Surgery,Lincheng People’s Hospital,Dezhou 253500,Shandong Province,China

出　　处：《World Journal of Gastroenterology》2022年第31期4328-4337,共10页世界胃肠病学杂志（英文版）

摘　　要：BACKGROUND Bile acids play an important role in the amelioration of type 2 diabetes following duodenal-jejunal bypass(DJB).Serum bile acids are elevated postoperatively.However,the clinical relevance is not known.Bile acids in the peripheral circulation reflect the amount of bile acids in the gut.Therefore,a further investigation of luminal bile acids following DJB is of great significance.AIM To investigate changes of luminal bile acids following DJB.METHODS Salicylhydroxamic acid(SHAM),DJB,and DJB with oral chenodeoxycholic acid(CDCA)supplementation were performed in a high-fat-diet/streptozotocininduced diabetic rat model.Body weight,energy intake,oral glucose tolerance test,luminal bile acids,serum ceramides and intestinal ceramide synthesis were analyzed at week 12 postoperatively.RESULTS Compared to SHAM,DJB achieved rapid and durable improvement in glucose tolerance and led to increased total luminal bile acid concentrations with preferentially increased proportion of farnesoid X receptor(FXR)-inhibitory bile acids within the common limb.Intestinal ceramide synthesis was repressed with decreased serum ceramides,and this phenomenon could be partially antagonized by luminal supplementation of FXR activating bile acid CDCA.CONCLUSION DJB significantly changes luminal bile acid composition with increased proportion FXR-inhibitory bile acids and reduces serum ceramide levels.There observations suggest a novel mechanism of bile acids in metabolic regulation after DJB.

关 键 词：Bariatric surgery Duodenal-jejunal bypass Farnesoid X receptor CERAMIDE Bile acids Liver fat accumulation 

分 类 号：R656.64[医药卫生—外科学]