LEUKOTRIENES

作品数：18被引量：41H指数：4
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相关领域：医药卫生更多>>
相关作者：张均田钟淼程桂芳朱秀媛王文杰更多>>
相关机构：中国医学科学院北京协和医学院浙江大学南京医科大学更多>>
相关期刊：《Science Bulletin》《Open Journal of Immunology》《Journal of Analytical Sciences, Methods and Instrumentation》《Chinese Journal of Chemistry》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Evaluating the effect of montelukast tablets on respiratory complications in patients following blunt chest wall trauma:A double-blind,randomized clinical trial
《Chinese Journal of Traumatology》2023年第2期116-120,共5页Soleyman Heydari Hadi Khoshmohabat Ali Taheri Akerdi Fathollah Ahmadpour Shahram Paydar 
Purpose:Patients with multiple traumas are at high risk of developing respiratory complications,including pneumonia and acute respiratory distress syndrome.Many pulmonary complications are associated with systemic inf...
关键词：Acute respiratory distress syndrome MONTELUKAST LEUKOTRIENES CONTUSIONS Injuries 
Bioactive lipids and cancer metastasis to bone
《Journal of Cancer Metastasis and Treatment》2021年第1期604-627,共24页Lou Saier Hira Niazi Leyre Brizuela Bodo Levkau Olivier Peyruchaud 
supported by grants from the INSERM(Peyruchaud O),the UniversitéClaude Bernard Lyon 1(Peyruchaud O);and the ANR grant BoneTAX(Grant No.ANR-20-CE14-0036-01)(Peyruchaud O);Saier L was the recipient of a fellowship from the French Ministère de l’Enseignement Supérieur et de la Recherche.Niazi H was supported by Higher Education Commission of Pakistan.This work was funded in part by the Else Kröner-Fresenius-Stiftung(Levkau B).
Bioactive lipids constitute a large family of molecules considered as inflammatory mediators.Among them,lysophosphatidic acid(LPA),sphingosine 1-phosphate(S1P),and eicosanoids(prostanoids such as PGE2 and leukotrienes...
关键词：Lysophosphatidic acid sphingosine 1-phosphate EICOSANOIDS PROSTAGLANDINS LEUKOTRIENES CANCER bone cells 
Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase被引量：1
《Acta Pharmaceutica Sinica B》2016年第1期32-45,共14页Yu Zhou Jun Liu Mingyue Zheng Shuli Zheng Chunyi Jiang Xiaomei Zhou Dong Zhang Jihui Zhao Deju Ye Mingfang Zheng Hualiang Jiang Dongxiang Liu Jian Cheng Hong Liu 
financial support from the National Natural Science Foundation of China(Grants Nos.91229204 and 81220108025);Major Project of Chinese National Programs for Fundamental Research and Development(No.2015CB910304);National High Technology Research and Development Program of China(No.2012AA020302);National Basic Research Program of China(No.2012CB518005);National S&T Major Projects(Nos.2012ZX09103101-072,2014ZX09507002-001,and 2013ZX09507-001)
Human 5-lipoxygenase (5-LOX) is a well-validated drug target and its inhibitors are potential drugs for treating leukotriene-related disorders. Our previous work on structural optimization of the hit compound 2 from o...
关键词：5-LIPOXYGENASE 5-LOX inhibitors Pyrazole derivatives Leukotrienes-related diseases In vivo Benzo-fuse heterocyle Ischemic incults Brain inflammation 
Characteristics of respiratory syncytial virus-induced bronchiolitis co-infection with Mycoplasma pneumoniae and add-on therapy with montelukast被引量：8
《World Journal of Pediatrics》2016年第1期88-95,共8页Sheng-Hua Wu Xiao-Qing Chen Xia Kong Pei-Ling Yin Ling Dong Pei-Yuan Liao Jia-Ming Wu 
supported by a grant from the Priority Academic Program Development of Jiangsu Higher Education Institution(JX10231801).
Background:The influence of Mycoplasma pneumoniae(MP)infection on bronchiolitis remains unclear.Additionally,reports on the efficacies of leukotriene receptor antagonists in the treatment of bronchiolitis have been in...
关键词：BRONCHIOLITIS LEUKOTRIENES MONTELUKAST Mycoplasma pneumoniae respiratory syncytial virus 
Regulatory effects of stage-treatment with established Chinese herbal formulas on inflammatory mediators in pediatric asthma被引量：8
《Journal of Traditional Chinese Medicine》2013年第6期727-732,共6页Suhuan Li Yonghong Wang Yumin Shi JianYu Wen Sun Hong Hu Yiqun Zhang 
Supported by Major Research Project of Shanghai Traditional Chinese Medicine Three-year Action Plan(ZYSNXD-CC-ZDYJ034);Shanghai Science and Technology Research Grant Program(No.12401905500);Shanghai Health Bureau Medical Research Fund Grant Program(No.2006L032A)
OBJECTIVE： To explore the regulatory effects of es- tablished Chinese herbal formulas on inflammatory mediators released during asthma attacks, and to elucidate the molecular mechanism of Traditional Chinese Medicine...
关键词：ASTHMA Drugs  Chinese herbal Empiri-cal prescriptions LEUKOTRIENES CYTOKINES 
Exhaled Breath Condensates as a Source for Biomarkers for Characterization of Inflammatory Lung Diseases
《Journal of Analytical Sciences, Methods and Instrumentation》2013年第1期17-29,共13页Puneet Bajaj Faoud T. Ishmael 
Inflammatory lung diseases such as asthma and chronic obstructive pulmonary disease are common and difficult to diagnose and characterize. This is due in large part to difficulty in obtaining samples directly from the...
关键词：Exhaled BREATH CONDENSATE Inflammation Biomarkers Hydrogen PEROXIDE Ph Micrornas NITRIC Oxide LEUKOTRIENES PROSTAGLANDINS Metabolomics 
Association ofALOX5,LTA4H and LTC4S gene polymorphisms with ischemic stroke risk in a cohort of Chinese in east China被引量：2
《World Journal of Emergency Medicine》2013年第1期32-37,共6页Gan-nan Wang Jin-song Zhang Wei-juan Cao Hao Sun Jing Zhang Yao Wang Hang Xiao 
BACKGROUND:Genetic variations of the 5-lipoxygenase activating protein and leukotriene A4 hydrolase genes that confer an increased risk of ischemic stroke have implicated the family of leukotrienes as potential mediat...
关键词：LEUKOTRIENES Gene polymorphisms Risk factors Ischemic stroke 
Association between genetic variants of the leukotriene biosynthesis pathway and the risk of stroke： a case-control study in the Chinese Han population被引量：4
《Chinese Medical Journal》2013年第2期254-259,共6页SUN Hao ZHANG Jing WANG Jun SUN Tao XIAO Hang ZHANG Jin-song 
Background Leukotrienes are arachidonic acid derivatives long known for their inflammatory properties. Leukotriene- based inflammation has been demonstrated to play a crucial role in atherosclerosis, a major risk fact...
关键词：leukotriene A4 hydrolase arachidonate 5-1ipoxygenase LEUKOTRIENES genetics  stroke 
Inhibitory effects of resveratrol on human mast cell degranulation, cytokine, chemokine and leukotriene release被引量：1
《Open Journal of Immunology》2012年第4期187-194,共8页Adriana Catalli Clayton MacDonald Priyanka Pundir Marianna Kulka 
Resveratrol, a polyphenol abundant in peanuts, red wine and the skin of grapes, has been shown to have anti-cancer, anti-oxidant and anti-inflammatory activities, and may also have beneficial effects on allergic infla...
关键词：Mast Cells RESVERATROL TRANILAST IgE Substance P LEUKOTRIENES 
Association of ALOX5AP with ischemic stroke in eastern Chinese被引量：7
《World Journal of Emergency Medicine》2012年第2期108-113,共6页Yao Wang Gan-nan Wang Hao Sun Chen Chen Hang Xiao Jin-song Zhang 
supported by Research Foundation of Jiangsu Province Hygiene Committee(H201005)
BACKGROUND：5-1ipoxygenase protein （ALOX5AP） has been recognized as a susceptibility gene for stroke and coronary artery diseases. The present study was to explore the role of this gene in the eastern Chinese patien...
关键词：5-1ipoxygenase activating protein （ALOX5AP） Leukotrienes （LTs） Trial of Org10172 in Acute Stroke Treatment （TOAST） Single nucleotide polymorphisms （SNPs） Ischemic stroke 
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