Bioactive lipids and cancer metastasis to bone  

作　　者：Lou Saier Hira Niazi Leyre Brizuela Bodo Levkau Olivier Peyruchaud 

机构地区：[1]INSERM,Unit 1033,LYOS,Lyon 69372,France [2]UniversitéClaude Bernard Lyon 1,Lyon 69372,France [3]INSERM Unit 970,Paris Cardiovascular Research Centre,Paris 75015,France [4]Universitéde Paris,Paris 75015,France [5]CNRS UMR 5246,INSA Lyon,Institut de Chimie et Biochimie Moléculaires et Supramoléculaires(ICBMS),Lyon 69622,France [6]Institute for Molecular Medicine III and University Hospital Düsseldorf,Düsseldorf,Heinrich Heine Universität,Düsseldorf 40225,Germany

出　　处：《Journal of Cancer Metastasis and Treatment》2021年第1期604-627,共24页癌症转移与治疗（英文版）

基　　金：supported by grants from the INSERM(Peyruchaud O),the UniversitéClaude Bernard Lyon 1(Peyruchaud O);and the ANR grant BoneTAX(Grant No.ANR-20-CE14-0036-01)(Peyruchaud O);Saier L was the recipient of a fellowship from the French Ministère de l’Enseignement Supérieur et de la Recherche.Niazi H was supported by Higher Education Commission of Pakistan.This work was funded in part by the Else Kröner-Fresenius-Stiftung(Levkau B).

摘　　要：Bioactive lipids constitute a large family of molecules considered as inflammatory mediators.Among them,lysophosphatidic acid(LPA),sphingosine 1-phosphate(S1P),and eicosanoids(prostanoids such as PGE2 and leukotrienes such as LTB4,LTC4,and LTD4)play a central role in the pathophysiology of several inflammatory diseases.However,it has long been known that these bioactive lipids are also involved in cancer,mainly because of their ability to control the pro-inflammatory microenvironment of tumors as well as their ability to act directly on tumor cells promoting cell proliferation,migration,and survival.Recently,there has been increased interest in determining how these lipid mediators orchestrate tumor development and metastasis.Bone metastases result from a complex dialogue between tumor cells and bone cells.Recent findings demonstrate that all these bioactive lipids can profoundly affect bone metabolism by acting positively or negatively on both osteoblasts and osteoclasts.This review gives an overview of previous findings demonstrating direct involvement of LPA,S1P,and PGE2 in bone metastasis.This review also emphasizes the recent findings that characterize the activity of these bioactive lipids directly on bone cells and how these activities could be integrated into the complex molecular mechanisms leading to bone metastasis formation and progression.

关 键 词：Lysophosphatidic acid sphingosine 1-phosphate EICOSANOIDS PROSTAGLANDINS LEUKOTRIENES CANCER bone cells 

分 类 号：R73[医药卫生—肿瘤]