Metabolic dysfunction-associated steatotic liver disease and omega- 6 polyunsaturated fatty acids: Friends or foes  

作　　者：Mona A Hegazy Safaa M Ahmed Shaimaa M Sultan Osama F Afifi Manal A Mohamed Alshimaa E Azab Mohamed A Hassanen Rakan K Zaben 

机构地区：[1]Department of Internal Medicine,Kasr Aliny Hospital,Faculty of Medicine,Cairo University,Cairo 12556,Egypt [2]Department of Neonatology,Mounira General Hospital,Cairo 4262130,Egypt [3]Department of Maternal and Pediatric Health,Shubra Elkhema Medical Administration,Qalyubia 13768,Egypt [4]Department of Neonatology,Ashmoun Hospital,Menofia 32811,Egypt [5]Department of Internal Medicine,Elnasr Hospital,Helwan 11731,Egypt [6]Department of Anesthesia,Al Helal Insurance Hospital,Qism Shebin 32514,Egypt [7]Department of Clinical Nutrition,Egyptian Fellowship,Cairo 11559,Egypt

出　　处：《World Journal of Hepatology》2025年第3期180-191,共12页世界肝病学杂志(英文)

摘　　要：BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD)is the most common chronic liver disease worldwide.Its prevalence is closely linked to the dramatic rise in obesity and non-communicable diseases.MASLD exhibits a progressive trajectory that may culminate in development of hepatic cirrhosis,thereby predisposing affected individuals to an elevated likelihood of hepatocarcinogenesis.Diet,especially dietary fatty acids,serves as a key link between nutrient intake and MASLD pathogenesis.AIM To explore the impact of various omega-6 fatty acid subtypes on the pathogenesis and therapeutic strategies of MASLD.METHODS A systematic literature search was conducted across Web of Science,PubMed,Cochrane Central,Scopus,and Embase databases from inception through June 2024 to identify all original studies linking different subtypes of omega-6 polyunsaturated fatty acids to the pathogenesis and management of MASLD.The search strategy explored the linkage between omega-6 polyunsaturated fatty acids and their subtypes,including linoleic acid(LA),gamma-linolenic acid(GLA),arachidonic acid,conjugated LA,and docosapentaenoic acid,in relation to MASLD and cardiometabolic risk.RESULTS By employing the specified search strategy,a total of 83 articles were identified as potentially eligible.During the title,abstract,and full-text screening phases,27 duplicate records were removed,leaving 56 records for relevance screening.Of these,43 records were excluded for reasons such as irrelevance and language restrictions(limited to English),resulting in 13 full-text articles being included for detailed assessment(10 human studies,1 animal study,and 2 review articles).Although certain subtypes,as GLA,dihomo-GLA,omega-6-derived oxylipins,and most arachidonic acid-derived eicosanoids,exhibit pro-inflammatory effects,our findings suggest that other subtypes such as LA,cis-9,trans-11 conjugated LA,and docosapentaenoic acid have beneficial effects on fatty liver,cardiometabolic risk factors,and inflammation,even at high intake le

关 键 词：Metabolic dysfunction-associated steatotic liver disease Omega-6 polyunsaturated fatty acids Conjugated linoleic acid Arachidonic acid Lipid metabolism Oxidative stress STEATOHEPATITIS EICOSANOIDS 

分 类 号：R57[医药卫生—消化系统]