CHONDROCYTE

作品数：116被引量：364H指数：11
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相关机构：武汉大学西安交通大学华中科技大学第四军医大学西京医院更多>>
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AAV-mediated expression of p65shRNA and bone morphogenetic protein 4 synergistically enhances chondrocyte regeneration
《中国组织工程研究》2025年第17期3537-3547,共11页Yu Yangyi Song Zhuoyue Lian Qiang Ding Kang Li Guangheng 
国家自然科学基金面上项目(81472136),项目负责人:李广恒。
BACKGROUND:Adeno-associated virus(AAV)gene therapy has been proven to be reliable and safe for the treatment of osteoarthritis in recent years.However,given the complexity of osteoarthritis pathogenesis,single gene ma...
关键词：OSTEOARTHRITIS adeno-associated virus bone morphogenetic protein 4 p65-short hairpin RNA gene therapy short hairpin RNA transforming growth factor-β1 extracellular matrix articular cartilage chondrocytes. 
Runx2 controls the osteogenic fate of growth plate chondrocytes
《Genes & Diseases》2025年第3期1-3,共3页Daofu Zeng Jiamin Yu Ke Lu Dan Yi Zhidao Xia Ling Qin Guozhi Xiao Xiao Yang Liping Tong Di Chen 
supported by the National Key Research and Development Program of China(No.2022YFA1207500);the National Natural Science Foundation of China(No.82394445 to D.C.and L.T.;82250710174 and 82030067 to D.C.;82161160342 to D.C.and L.Q.);the Shenzhen Science and Technology Research Funding(No.JCYJ20220818101414032 to L.T.;JSGGKQTD20210831174330015 to D.C.).
The origin of bone marrow osteoblasts is not totally understood.Recent findings demonstrated that bone marrow osteoblasts could be derived from a subpopulation of hypertrophic Col2^(+)/Col10^(+)chondrocytes which migr...
关键词：RUNX mesenchymal progenitor cells chondrocyte osteoblast transdifferentiation hypertrophic chondrocytes growth plate bone marrow bone marrow osteoblasts 
HOXB6 down-regulation induced by retinoic acid pathway repression leads to chondrocyte proliferation inhibition and apoptosis in microtia
《Genes & Diseases》2025年第3期23-26,共4页Run Yang Xin Chen Siyi Wu Chenlong Li Ying Chen Yaoyao Fu Aijuan He Duan Ma Jing Ma Tianyu Zhang 
supported by the National Natural Science Foundation of China(No.82271889,82371173);the National Key Research and Development Program of China(No.2021YFC2701000);the Natural Science Foundation Project of Shanghai Science and Technology Innovation Action Plan(China)(No.23ZR1409400);Shanghai Science and Technology Commission of China(No.21DZ2200700).
Microtia,a congenital malformation affecting the external and middle ear,arises from disruptions during the development of embryonic branchial arches and cranial neural crest cells(CNCCs),making it the second most pre...
关键词：aberrant gene expression skeletal patterningand congenital malformation maxillofacial birth defect hoxb conductive hearing loss retinoic acid pathway embryonic branchial arches 
The miR-6779/XIAP axis alleviates IL-1β-induced chondrocyte senescence and extracellular matrix loss in osteoarthritis
《Animal Models and Experimental Medicine》2025年第4期662-673,共12页Zongchao Li Aonan Dai Xiaoxiang Fang Kexing Tang Kun Chen Peng Gao Jingyue Su Xin Chen Shengwu Yang Zhenhan Deng Liangjun Li 
Natural Science Foundation of Changsha city,China,Grant/Award Number:kq2403166;Hunan Provincial Clinical Medical Technology Innovation Guiding Project,Grant/Award Number:2020SK53307;Basic Public Welfare Research projects of Wenzhou Science and Technology Bureau,Grant/Award Number:Y20240087;Natural Science Foundation of Hunan Province,Grant/Award Number:2020JJ8043;Start-up Funding for Talented Scientific Research of the First Affiliated Hospital of Wenzhou Medical University,Grant/Award Number:2023QD026;Key Project of Hunan Provincial Health Commission,Grant/Award Number:20201902 and C2019133;National Natural Science Foundation of China,Grant/Award Number:82472495。
Background:Osteoarthritis(OA)is a long-term degenerative joint disease worsen-ing over time.Aging and chondrocyte senescence contribute to OA progression.MicroRNAs have been confirmed to regulate different cellular pr...
关键词：CHONDROCYTE miR-6779 OSTEOARTHRITIS SENESCENCE X-linked inhibitor of apoptosis protein 
Single-cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis
《Genes & Diseases》2025年第2期383-397,共15页Changyuan Huangg Bin Zeng Bo Zhou Guanming Chen Qi Zhang Wenhong Hou Guozhi Xiao Li Duan Ni Hong Wenfei Jin 
supported by the National Key R&D Program of China (No.2021YFF1200900);National Natural Science Foundation of China (No.32170646,8197211);Guangdong Basic and Applied Basic Research Foundation (China) (No.2023A1515011908 to N.H.);Key-Area Research and Development Program of Guangdong Province,China (No.2023B1111020006);International Science and Technology CooperationnProgramnofGuangdong,China (No.2021A0505030011);Shenzhen Innovation Committee of Science and Technology (Guangdong,China) (No.JCYJ20220818100401003);Shenzhen Science and Technology Program (Guangdong,China) (No.SGDX20201103095800003,GJHZ20200731095606019,JCYJ20220818100401003);Shenzhen High-level Hospital Construction Fund (Guangdong,China) (No.1801004).
Chondrocyte is considered the only cell type in cartilage.However,the cell hetero-geneity of chondrocytes in human articular cartilage is still not well defined,which hinders our understanding of the pathogenesis of o...
关键词：Cell heterogeneity Chondrocyte apoptosis Chondrocyte differentiation Chondrocyte fibrosis OSTEOARTHRITIS Single-cell RNA-seq 
Wnt2bb signaling promotes pharyngeal chondrogenic precursor proliferation and chondrocyte maturation by activating Yap expression in zebrafish
《Journal of Genetics and Genomics》2025年第2期220-230,共11页Xiaojuan Guo Liping Yang Yujie Wang Mengna Yuan Wenqing Zhang Xinyu He Qiang Wang 
support of the National Natural Science Foundation of China(32025014 and 32330029 to Q.W.);the National Key Research and Development Program of China(2020YFA0804000 to Q.W.);Guangdong Excellent Youth Team Project(2024B1515040019 to Q.W.);Guangzhou Science and Technology Plan Project(202201010323 to X.H.);the Fundamental Research Funds for the Central Universities(to Q.W.).
Pharyngeal cartilage morphogenesis is crucial for the formation of craniofacial structures.Cranial neural crest cells are specified at the neural plate border,migrate to pharyngeal arches,and differentiate into pharyn...
关键词：Wnt/β-catenin signaling YAP Wnt2bb Chondrocyte maturation Pharyngeal cartilage ZEBRAFISH 
EZH2/miR-142-3p/HMGB1 axis mediates chondrocyte pyroptosis by regulating endoplasmic reticulum stress in knee osteoarthritis
《Chinese Medical Journal》2025年第1期79-92,共14页Yang Chen Shanshan Dong Xin Zeng Qing Xu Mingwei Liang Guangneng Liao Lan Li Bin Shen Yanrong Lu Haibo Si 
supported by the National Natural Science Foundation of China(No.81802210);the Science&Technology Department of Sichuan Province(No.2021YFS0122);the Health Commission of Sichuan Province(No.20PJ056);the National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University(No.Z2018B20).
Background:Knee osteoarthritis(OA)is still challenging to prevent or treat.Enhanced endoplasmic reticulum(ER)stress and increased pyroptosis in chondrocytes may be responsible for cartilage degeneration.This study aim...
关键词：OSTEOARTHRITIS EZH2 MicroRNA-142-3p HMGB1 Endoplasmic reticulum stress PYROPTOSIS 
Poly(p-coumaric acid)nanoparticles alleviate temporomandibular joint osteoarthritis by inhibiting chondrocyte ferroptosis
《Bioactive Materials》2024年第10期212-226,共15页Jiaxin Guo Kai Su Liying Wang Bingyu Feng Xinru You Miao Deng Wei Seong Toh Jun Wu Bin Cheng Juan Xia 
supported by grants from the National Natural Science Foundation of China(Grant No.82170960 and No.52173150);the Science and Technology Program of Guangzhou,China(Grant No.202206080009);Guangzhou Science and Technology Program City-University Joint Funding Project(Grant No.2023A03J0001);China Postdoctoral Science Foundation(Grant No.2022M723670).
Oxidative stress and inflammation are key drivers of osteoarthritis(OA)pathogenesis and disease progression.Herein we report the synthesis of poly(p-coumaric)nanoparticles(PCA NPs)from p-courmaic acid(p-CA),a naturall...
关键词：Temporomandibular joint osteoarthritis Poly(p-coumaric acid)nanoparticles Ferroptosis Oxidative pressure CARTILAGE 
Bioceramic-mediated chondrocyte hypertrophy promotes calcified cartilage formation for rabbit osteochondral defect repair
《Bioactive Materials》2024年第10期306-317,共12页Rachel H.Koh Junhee Kim Jeong-Uk Kim Seunghyun L.Kim Arun Kumar Rajendran Seunghun SLee Heesoo Lee Joo Hyun Kim Ji Hoon Jeong Yongsung Hwang Jong Woo Bae Nathaniel S.Hwang 
supported by the National Research Foundation of Korea(NRF)grant funded by the Korean government(NRF-2021K1A3A1A57086407,NRF-2021R1A2C2008821,NRF-2022R1I1A1A01071991);Arun Kumar Rajendran was supported by the National Research Foundation of Korea(NRF)grant Brain Pool program funded by the Ministry of Science and ICT through the National Research Foundation of Korea(2020H1D3A1A04081286);The Institute of Engineering Research at Seoul National University provided research facilities,and additional support came from the SNU Engineering-Medicine Collaboration grant.
Osteochondral tissue is a highly specialized and complex tissue composed of articular cartilage and subchondral bone that are separated by a calcified cartilage interface.Multilayered or gradient scaffolds,often in co...
关键词：BIOCERAMIC Whitlockite Bilayer scaffold Chondrocyte hypertrophy Osteochondral defect repair 
Mitochondrial-Oriented Injectable Hydrogel Microspheres Maintain Homeostasis of Chondrocyte Metabolism to Promote Subcellular Therapy in Osteoarthritis被引量：2
《Research》2024年第3期775-790,共16页Li Chen Jianye Yang Zhengwei Cai Yanran Huang Pengcheng Xiao Hong Chen Xiaoji Luo Wei Huang Wenguo Cui Ning Hu 
the National Natural Science Foundation of China(82072443 and 82372425);the China Postdoctoral Science Foundation(Grant No.2022M710557);the Natural Science Foundation of Chongqing,China(Grant No.CSTB2023NSCQ-BHX0011);the Young Excellent Science and Technology Talent Project of the First Affiliated Hospital of Chongqing Medical University(Grant No.ZYRC2022-05).
Subcellular mitochondria serve as sensors for energy metabolism and redox balance, and the dynamic regulation of functional and dysfunctional mitochondria plays a crucial role in determining cells' fate. Selective rem...
关键词：SPHERES REMOVE thereby 
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