Poly(p-coumaric acid)nanoparticles alleviate temporomandibular joint osteoarthritis by inhibiting chondrocyte ferroptosis  

作　　者：Jiaxin Guo Kai Su Liying Wang Bingyu Feng Xinru You Miao Deng Wei Seong Toh Jun Wu Bin Cheng Juan Xia 

机构地区：[1]Hospital of Stomatology,Sun Yat-sen University,Guangzhou,510055,PR China [2]Guangdong Provincial Key Laboratory of Stomatology,Guangzhou,510055,PR China [3]Department of Hematology,The Seventh Affiliated Hospital,Sun Yat-sen University,Shenzhen,518107,PR China [4]Center for Nanomedicine and Department of Anesthesiology,Brigham and Women’s Hospital,Harvard Medical School,Boston,MA 02115,USA [5]Department of Orthopaedic Surgery,Yong Loo Lin School of Medicine,National University of Singapore,119228,Singapore [6]Faculty of Dentistry,National University of Singapore,119085,Singapore [7]Bioscience and Biomedical Engineering Thrust,The Hong Kong University of Science and Technology(Guangzhou),Nansha,Guangzhou,511455,PR China [8]Division of Life Science,The Hong Kong University of Science and Technology,Hong Kong,China

出　　处：《Bioactive Materials》2024年第10期212-226,共15页生物活性材料（英文）

基　　金：supported by grants from the National Natural Science Foundation of China(Grant No.82170960 and No.52173150);the Science and Technology Program of Guangzhou,China(Grant No.202206080009);Guangzhou Science and Technology Program City-University Joint Funding Project(Grant No.2023A03J0001);China Postdoctoral Science Foundation(Grant No.2022M723670).

摘　　要：Oxidative stress and inflammation are key drivers of osteoarthritis(OA)pathogenesis and disease progression.Herein we report the synthesis of poly(p-coumaric)nanoparticles(PCA NPs)from p-courmaic acid(p-CA),a naturally occurring phytophenolic acid,to be a multifunctional and drug-free therapeutic for temporomandibular joint osteoarthritis(TMJOA).Compared to hyaluronic acid(HA)that is clinically given as viscosupplementation,PCA NPs exhibited long-term efficacy,superior anti-oxidant and anti-inflammatory properties in alleviating TMJOA and repairing the TMJ cartilage and subchondral bone in a rat model of TMJOA.Notably,TMJ repair mediated by PCA NPs could be attributed to their anti-oxidant and anti-inflammatory properties in enhancing cell proliferation and matrix synthesis,while reducing inflammation,oxidative stress,matrix degradation,and chondrocyte ferroptosis.Overall,our study demonstrates a multifunctional nanoparticle,synthesized from natural p-coumaric acid,that is stable and possess potent antioxidant,anti-inflammatory properties and ferroptosis inhibition,beneficial for treatment of TMJOA.

关 键 词：Temporomandibular joint osteoarthritis Poly(p-coumaric acid)nanoparticles Ferroptosis Oxidative pressure CARTILAGE 

分 类 号：R68[医药卫生—骨科学]