Food-derived peptides with inhibitory capacity for HMG-CoA reductase activity: a potential nutraceutical for hypercholesterolemia  

作　　者：Guillermo Santos-Sánchez Ana IsabelÁlvarez-López Eduardo Ponce-España Patricia Judith Lardone Antonio Carrillo-Vico Ivan Cruz-Chamorro 

机构地区：[1]Instituto de Biomedicina de Sevilla,Instituto de Biomedicina de Sevilla(IbiS),Hospital Universitario Virgen del Rocío,Consejo Superior de Investigaciones Científi cas(CSIC),Universidad de Sevilla,Seville 41013,Spain [2]Departamento de Bioquímica Médica y Biología Molecular e Inmunología,Facultad de Medicina,Universidad de Sevilla,Seville 41009,Spain

出　　处：《Food Science and Human Wellness》2024年第6期3083-3094,共12页食品科学与人类健康（英文）

基　　金：funded by Consejería de Salud, Junta de Andalucía (PC-0111-2016-0111);PEMP-0085-2020 (cofinanciado con fondos FEDER, convocatoria Resolución de 7 de julio de 2021 de la Secretaría General de Investigación, Desarrollo e Innovación en Salud, que convoca subvenciones para financiar la investigación, el desarrollo y la innovación en Biomedicina y Ciencias de la Salud en Andalucía, para 2021);the Programa PAIDI from the Junta de Andalucía (CTS160);supported by a FPU grant from the Spanish Ministerio de Educación, Cultura y Deporte (FPU16/02339);supported by the VI Program of Inner Initiative for Research and Transfer of the University of Seville (VIPPIT2020-II.4);by a postdoctoral fellowship from the Andalusian Government Ministry of Economy, Knowledge, Business, and University (DOC_00587/2020);funded by Andalusian Government Ministry of Health (PI-0136-2019);supported by the VI Program of Inner Initiative for Research and Transfer of University of Seville

摘　　要：Cardiovascular diseases(CVDs)are the leading global cause of mortality and disease burden.Statins are the most prescribed lipid-lowering drugs to treat hypercholesterolemia and prevent CVDs.The biochemical mechanism of statins consists of competitive inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase enzyme(HMG-CoAR),the limiting enzyme in cholesterol biosynthesis.Due to statin intolerance in some patient groups,the search for new inhibitors is a field of great interest.This review focusses on the studies reporting the inhibitory effect of protein hydrolysates and biopeptides on the HMG-CoAR enzyme activity.The analysis of the action mechanism and physicochemical characteristics of the HMG-CoAR inhibitory peptides revealed that the molecular weight,amino acid composition,charge,and polarity are key aspects of the interaction with the HMG-CoAR enzyme.In conclusion,this review reveals the potential of using food peptides as new cholesterol-lowering agents and opens a new interesting field of research.However,clinical approaches are mandatory to confirm their therapeutic hypercholesterolemic effect.

关 键 词：Functional foods Cholesterol Cardiovascular diseases STATINS 3-Hydroxy-3-methylglutaryl-coenzyme A 

分 类 号：TS201.4[轻工技术与工程—食品科学] TQ460.1[轻工技术与工程—食品科学与工程]