Atorvastatin ameliorated myocardial fibrosis by inhibiting oxidative stress and modulating macrophage polarization in diabetic cardiomyopathy  

作　　者：Xiao-Tian Lei Dan-Lan Pu Geng Shan Qi-Nan Wu 

机构地区：[1]Department of Endocrinology,The First Affiliated Hospital of the Third Military Medical University(Army Medical University),Chongqing 400038,China [2]Department of Endocrinology,Chongqing Yubei District People's Hospital,Chongqing 400030,China [3]Department of Endocrinology,Dazu Hospital of Chongqing Medical University,The People's Hospital of Dazu,Chongqing 402360,China

出　　处：《World Journal of Diabetes》2024年第6期1070-1073,共4页世界糖尿病杂志（英文版）（电子版）

基　　金：Supported by National Natural Science Foundation of China,No.82000792;General project of Chongqing Natural Science Foundation,No.cstc2020jcyj-msxm0409.

摘　　要：In this editorial,we commented on the article published in the recent issue of the World Journal of Diabetes.Diabetic cardiomyopathy(DCM)is characterized by myocardial fibrosis,ventricular hypertrophy and diastolic dysfunction in diabetic patients,which can cause heart failure and threaten the life of patients.The pathogenesis of DCM has not been fully clarified,and it may involve oxidative stress,inflammatory stimulation,apoptosis,and autophagy.There is lack of effective therapies for DCM in the clinical practice.Statins have been widely used in the clinical practice for years mainly to reduce cholesterol and stabilize arterial plaques,and exhibit definite cardiovascular protective effects.Studies have shown that statins also have anti-inflammatory and antioxidant effects.We were particularly concerned about the recent findings that atorvastatin alleviated myocardial fibrosis in db/db mice by regulating the antioxidant stress and antiinflammatory effects of macrophage polarization on diabetic myocardium,and thereby improving DCM.

关 键 词：Diabetic cardiomyopathy STATINS MACROPHAGE Oxidative stress 

分 类 号：R285[医药卫生—中药学]