ΑVΒ3

作品数：90被引量：249H指数：7
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相关机构：华中科技大学山西医科大学湖南中医药大学北京大学第一医院更多>>
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Non-invasively differentiate non-alcoholic steatohepatitis by visualizing hepatic integrin αvβ3 expression with a targeted molecular imaging modality
《World Journal of Hepatology》2024年第11期1290-1305,共16页Xiao-Quan Huang Ling Wu Chun-Yan Xue Chen-Yi Rao Qing-Qing Fang Ying Chen Cao Xie Sheng-Xiang Rao Shi-Yao Chen Feng Li 
Supported by the National Natural Science Foundation of China,No.81670513;and Young Scientists Fund of the National Natural Science Foundation of China,No.81900511。
BACKGROUND Non-invasive methods to diagnose non-alcoholic steatohepatitis(NASH),an inflammatory subtype of non-alcoholic fatty liver disease(NAFLD),are currently unavailable.AIM To develop an integrin αvβ3-targeted ...
关键词：Non-alcoholic steatohepatitis Cyclic peptides Magnetic resonance imaging Non-invasive diagnosis Hepatic integrinαvβ3 
αvβ3、VEGF-A、VEGFR-2及PTN对肿瘤血管内皮细胞活动的串扰
《中文科技期刊数据库（全文版）医药卫生》2024年第4期0179-0183,共5页高雅儒 王雪梅 
肿瘤是目前最大的公共健康问题之一,威胁着全世界数百万人的健康。肿瘤血管通过为肿瘤组织输送氧气、提供营养物质促进肿瘤进展。其中,肿瘤血管内皮细胞(ECs)的增殖、迁移等一系列活动是肿瘤血管生成的关键。近年来,国内外大量研究证明...
关键词：肿瘤血管 内皮细胞 迁移过程 
Elevating theranostics:The emergence and promise of radiopharmaceutical cell-targeting heterodimers in human cancers
《iRADIOLOGY》2024年第2期128-155,共28页Claudia Chambers Broc Chitwood Charles J.Smith Yubin Miao 
NIH Research Evaluation and Commercilization Hub,Grant/Award Number:1U01HL152410;USVA Medical Research Service,Grant/Award Number:I01 BX00096409;National Institutes of Health,Grant/Award Numbers:R01CA269221,R01CA225837。
Optimal therapeutic and diagnostic efficacy is essential for healthcare's global mission of advancing oncologic drug development.Accurate diagnosis and detection are crucial prerequisites for effective risk stratifica...
关键词：HETERODIMER heterobivalent hybrid peptide PSMA GRPR ΑVΒ3 SST MSH 
Milk fat globule epidermal growth factor 8 alleviates liver injury in severe acute pancreatitis by restoring autophagy flux and inhibiting ferroptosis in hepatocytes被引量：1
《World Journal of Gastroenterology》2024年第7期728-741,共14页Qing Cui Hang-Cheng Liu Wu-Ming Liu Feng Ma Yi Lv Jian-Cang Ma Rong-Qian Wu Yi-Fan Ren 
Supported by the National Natural Science Foundation of China,No.82100685;the Scientific Research Fund of Xi’an Health Commission,No.2021yb08;Scientific Research Fund of Xi’an Central Hospital,No.2022QN07;Innovation Capability Support Plan of Xi’an Science and Technology Bureau,No.23YXYJ0097.
BACKGROUND Liver injury is common in severe acute pancreatitis(SAP).Excessive autophagy often leads to an imbalance of homeostasis in hepatocytes,which induces lipid peroxidation and mitochondrial iron deposition and ...
关键词：Autophagy flux Ferroptosis Liver injury Milk fat globule epidermal growth factor 8 αvβ3/5 integrins Acute pancreatitis 
CXCR4通过integrinαVβ3调控头颈部鳞癌细胞迁移的机制研究被引量：1
《现代肿瘤医学》2023年第9期1584-1588,共5页常艳艳 李鹏 孟金平 陈艳艳 
河南省医学科技攻关计划项目(编号:2018020488)。
目的:研究C-X-C型趋化因子受体4(CXCR4)-整合素αVβ3(integrinαVβ3)介导头颈部鳞癌细胞迁移的分子生物学机制。方法:应用头颈部鳞癌细胞株HN-5,采用慢病毒转染方法构建CXCR4过表达的细胞株,用荧光显微镜观察基因表达情况;采用脂质体...
关键词：CXCR4 integrinαVβ3 头颈部鳞癌 细胞迁移 
CTGF/CCN2 promotes the proliferation of human osteosarcoma cells via cross-talking with the stromal CXCL12/CXCR4-AKT-αvβ3 signaling axis in tumor microenvironment被引量：2
《Genes & Diseases》2023年第2期356-358,共3页Zhangxu Zhou Shujuan Yan Ruyi Zhang Hao Wang Ziqian Ye Zhilun Zhang Keyu Li Guowei Zuo 
supported by the National Natural Science Foundation of China(No.81102035,and 82060388);Doctor Foundation of Guizhou Provincial People's Hospital(No.GZSYBS[2019]08);Guizhou High-level Innovative Talents Project(No.QKPT[2017]5724-6);Guizhou Department and Platform Talents(No.[2017]5735-31);Science and Technology Department of Guizhou Province(No.QKHJC[2021-396]).
Osteosarcoma (OS) is the most common histological form of primary bone cancer in childhood cancer and young adults. At present, OS is widely investigated because of the interaction between the tumor and bone microenvi...
关键词：CCN2 MICROENVIRONMENT OSTEOSARCOMA 
JP1,a polypeptide specifically targeting integrinαVβ3,ameliorates choroidal neovascularization and diabetic retinopathy in mice被引量：3
《Acta Pharmacologica Sinica》2023年第4期897-912,共16页Zhan Xie Xin-jing Wu Rui-wen Cheng Jia-hua Cui Song-tao Yuan Jian-wei Zhou Qing-huai Liu 
supported by the National Natural Science Foundation of China(Nos.81970821,81973156,81770973,81870694).
Anti-vascular endothelial growth factor(VEGF)drugs have revolutionized the treatment of neovascular eye diseases,but responses are incomplete in some patients.Recent evidence shows that integrins are involved in the p...
关键词：choroidal neovascularization diabetic retinopathy JP1 oxidative stress inflammation ANGIOGENESIS 
糖尿病视网膜病变患者血清Periostin、αvβ3、25(OH)D_(3)水平变化及相关性分析被引量：1
《标记免疫分析与临床》2023年第3期427-431,458,共6页曹柳 王麦 刘珊 
河北省科学技术厅科技计划项目(编号:162777284)。
目的基于血清骨膜蛋白(Periostin)、整合素αvβ3、25-羟基维生素D_(3)[25(OH)D_(3)]指标,探究糖尿病视网膜病变(DR)患者血清Periostin、αvβ3、25(OH)D_(3)水平变化及相关性。方法选取2020年5月至2022年5月于本院进行诊治的178例糖尿...
关键词：糖尿病视网膜病变 骨膜蛋白 整合素ΑVΒ3 25-羟维生素D_(3) 相关性 
Discovery of C19-9 as a novel non-RGD inhibitor of αvβ3 to overcome enzalutamide resistance in castration-resistant prostate cancer
《Signal Transduction and Targeted Therapy》2023年第3期891-894,共4页Xiaocong Pang Xiaojiao Sun Yanlun Gu Xu He Kan Gong Song Song Jixin Zhang Jie Xia Zhenming Liu Yimin Cui 
This research was funded by National High Level Hospital Clinical Research Funding(Scientific and Technological Achievements Transformation Incubation Guidance Fund Project of Peking University First Hospital)(No.2022CX11,No.2022RT01);National Key R&D Program of China(No.2020YFC2008304);National Natural Science Foundation of China(No.81973320 and No.81903714).Thanks to Dr.Qian Wang in the State Key Laboratory of Natural and Biomimetic Drugs,Peking University for the experimental assistance of SPR.Thanks to K2 Oncology Co.Ltd.for experimental assistance with patient-derived organoids.
Dear Editor,The integrinαvβ3 receptor is a promising target for anticancer therapy.1,2 However,there are no effective marketed treatments targetingαvβ3.One possible limitation of Arginine-Glycine-Aspartic(RGD)-mim...
关键词：ΑVΒ3 OVERCOME RESISTANCE 
骨痛灵方通过抑制整合素αvβ3通路缓解肺癌骨转移癌性疼痛被引量：5
《中国疼痛医学杂志》2023年第2期92-100,共9页孟唤男 郭晓冬 周小翠 陈舲 王立玉 吕英 徐振晔 
国家自然科学基金(81704042)。
目的:探讨骨痛灵(Gutongling,GTL)方治疗肺癌骨转移疼痛的潜在作用机制。方法:将50只C57BL/6雄性小鼠随机分为5组(n=10):假手术组(Sham组)、模型组(Model组)、唑来膦酸组(ZA组)、骨痛灵组(GTL组)、骨痛灵+唑来膦酸组(GTL+ZA组)。除Sham...
关键词：肺癌骨转移 癌痛 骨痛灵方 唑来膦酸 αvβ3通路 F-actin环 
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