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细胞焦亡在乳腺癌治疗中的机制及潜在应用策略: 《中国组织工程研究》2025年第36期7880-7888,共9页冉亚琴陈曦谢晏讷袁军; 贵州省科学技术厅项目(黔科合基础[2019]1004号),项目负责人:袁军;贵阳市科技计划项目(筑科合同[2019]9-9-2号),项目负责人:袁军。; 背景:众多研究指出细胞焦亡在肿瘤进展中扮演着关键角色。近年来研究显示,细胞焦亡与乳腺癌发生、发展和治疗有着不可忽视的联系,开发有效的细胞焦亡治疗策略已成为乳腺癌治疗领域的研究热点。目的:综合分析细胞焦亡的机制,探究细胞焦...; 关键词：细胞焦亡乳腺癌炎症小体 Gasdermin家族蛋白 caspase家族蛋白预后价值工程化组织构建

Chlorogenic acid alleviates IPEC‑J2 pyroptosis induced by deoxynivalenol by inhibiting activation of the NF‑κB/NLRP3/ caspase‑1 pathway: 《Journal of Animal Science and Biotechnology》2025年第2期797-812,共16页Yanmei Xue Fuchang Li Rui Li Xinru Zhang Huijun Guo Chunyang Wang; supported by the National Natural Science Foundation of China(32373062);the Natural Science Foundation of Shandong Province(ZR2023MC144);Funds of Shandong Province Modern Agricultural Technology System Innovation Team Program(SDAIT-21-10).; Background Deoxynivalenol(DON)is a mycotoxin that severely pollutes feed ingredients,and methods for reducing DON toxicity have become a significant research direction.Chlorogenic acid(CGA)is an active polyphenol foun...; 关键词：Chlorogenic acid DEOXYNIVALENOL IPEC-J2 cells PYROPTOSIS Signaling pathway

黄芩苷通过调控Bcl-2/Bax/Caspase 3凋亡细胞改善睡眠障碍诱导的认知功能障碍: 《海南医科大学学报》2025年第8期599-607,共9页向桂珍秦明凯孙毅红杨占君贾建新闫旭升; 国家自然科学基金资助项目(81860215);内蒙古自治区卫生健康委医疗卫生科技计划项目(202201400);内蒙古自治区自然科学基金(2024MS08051);包头市卫生健康科技计划项目(wsjkkj2022069);2023年青苗计划项目(BYJJ-ZRQM 202310)。; 目的:基于网络药理学及动物实验探讨黄芩苷(Baicalin,BA)通过调控Bcl-2/Bax/Caspase 3凋亡细胞改善睡眠障碍(SD)诱导的认知功能障碍的可能机制。方法:利用网络药理学预测BA和SD的相关靶点,将70只雄性8周龄SD大鼠随机分组:空白组、50 mg...; 关键词：黄芩苷睡眠障碍认知功能凋亡氧化应激

TNFα-reliant FSP1 up-regulation promotes intervertebral disc degeneration via caspase 3-dependent apoptosis: 《Genes & Diseases》2025年第1期327-340,共14页Cheng Qiu Lin Cheng Derun Di Ziqian Xiang Congyu Wang Jinghang Li Yinuo Xiong Manyu Li Jingwei Liu Jian Zhou Tianyi Liu Xinyu Wang Dan Luo Xiaoxiong Wang Shangye Li Hui Wang Xia Wang Yunpeng Zhao Xinyu Liu Lianlei Wang; supported in part by the National Natural Science Foundation of China(No.81874022 and 82172483 to Xinyu Liu,No.82102522 to Lianlei Wang);Key R&D Project of Shandong Province(China)(No.2022CXGC010503 to Xinyu Liu);Shandong Natural Science Foundation(No.ZR202102210113 to Lianlei Wang);Shandong Province Taishan Scholar Project(No.tsqn 202211317 to Lianlei Wang);National High Level Hospital Clinical Research Funding(No.2022-PUMCH-D-004).; Intervertebral disc degeneration(IDD)is a common chronic inflammatory degenerative disease that causes lower back pain.However,the underlying mechanisms of IDD remain unclear.Ferroptosis suppressor protein 1(FSP1)is a...; 关键词：Caspase 3 FSP1 iFSP1 Intervertebraldisc degeneration NF-ΚB TNFΑ

基于Caspase⁃4/GSDME通路介导的细胞焦亡探讨桂枝茯苓胶囊对卵巢癌细胞周期的作用机制: 《海南医科大学学报》2025年第3期193-199,共7页赵磊郭琦蔡萧君吴心力陈宇菲; 黑龙江省博士后专项经费(LBH-Z22275)。; 目的:观察桂枝茯苓胶囊对Caspase-4/GSDME通路介导的细胞焦亡的影响,从而阐明其调控细胞周期治疗卵巢癌的分子机制。方法:人卵巢癌细胞株SKOV3分为空白组、桂枝茯苓胶囊低、中、高剂量组和抑制剂组,并对相应的药物进行干预。分别采用CCK...; 关键词：桂枝茯苓胶囊 Caspase-4/GSDME通路细胞焦亡细胞周期卵巢癌

Transcriptome and single-cell profiling of the mechanism of diabetic kidney disease: 《World Journal of Diabetes》2025年第2期216-236,共21页Ying Zhou Xiao Fang Lin-Jing Huang Pei-Wen Wu; Joint Funds for the Innovation of Science and Technology,Fujian Province,No.2021Y9106;Fujian Provincial Health Technology Project,No.2021GGA033;the Natural Science Foundation of Fujian Province,No.2024J011234.; BACKGROUND The NOD-like receptor thermal protein domain associated protein 3(NLRP3)inflammasome may play an important role in diabetic kidney disease(DKD).However,the exact link remains unclear.AIM To investigate the ...; 关键词：Diabetic kidney disease Single-cell RNA sequencing analysis NOD-like receptor thermal protein domain associated protein 3 Sirtuin 2 Caspase 1

针刺四关穴联合加巴喷丁对NP患者的疗效及NLRP3/Caspase⁃1/IL⁃1β的影响: 《分子诊断与治疗杂志》2025年第1期175-178,183,共5页何慧鑫刘智谢文秀李维娜周启; 湖南省自然科学基金科卫联合项目(2023JJ60347);湖南省教育厅优秀青年项目(24B0371);湖南中医药大学校级课题项目(2020XJJJ048)。; 目的探究针刺四关穴联合加巴喷丁对癌性神经病理性疼痛(NP)疗效及Nod样受体蛋白3(NLRP3)/半胱氨酸蛋白酶⁃1(Caspase⁃1)/白细胞介素(IL)⁃1β的影响。方法纳入2023年2月至2024年4月湖南中医药大学第一附属医院收治的癌性NP患者137例,依治...; 关键词：针刺加巴喷丁 Nod样受体蛋白3 半胱氨酸蛋白酶⁃1 白细胞介素⁃1β 癌性神经病理性疼痛

Bioengineered silver nanoparticles induced apoptosis through upregulation of caspase 3 and caspase 8 proteins in breast adenocarcinoma MDA-MB-231 cells and impede angiogenesis: 《Particuology》2024年第12期252-264,共13页Shahnaz Majeed Nurul Izzah Binti Abu Bakar Mohammad Danish Afzan Binti Mahmad Mohamad Nasir Mohamad Ibrahim Norul Aini Zakariya Sreenivas Patro Sisinthy Ravindran Muthukumarasamy Abdulaziz M.Alanazi Mohammed Tahir Ansari Ohoud A.Jefri; In recent years,a lot of research has been done on silver nanoparticles(SNP)due to their numerous applications in the biomedical,pharmaceutical,and drug delivery industries.In this present study SNP were green synthes...; 关键词：Silver nanoparticles TEM ANTI-ANGIOGENESIS DAPI ROS

急性心肌梗死PCI术后HF患者外周血NLRP3、Caspase⁃1、IL⁃1β的表达及意义: 《分子诊断与治疗杂志》2024年第11期2130-2134,共5页付振强安松涛孙国举吴帆; 河南省医学科技攻关计划联合共建项目(LHGJ20191389)。; 目的探讨急性心肌梗死(AMI)经皮冠状动脉介入治疗(PCI)术后心力衰竭(HF)患者外周血核苷酸寡聚化结构域样受体热蛋白结构域相关蛋白3(NLRP3)、半胱氨酸天门冬氨酸蛋白水解酶⁃1(Caspase⁃1)、白细胞介素⁃1β(IL⁃1β)的表达及意义。方法选...; 关键词：急性心肌梗死经皮冠状动脉介入治疗心力衰竭核苷酸寡聚化结构域样受体热蛋白结构域相关蛋白3 半胱氨酸天门冬氨酸蛋白水解酶⁃1 白细胞介素⁃1β

Identification of a novel caspase cleavage motif AEAD: 《Virologica Sinica》2024年第5期755-766,共12页Yujie Fang Zhou Gong Miaomiao You Ke Peng; supported by the National Key R&D Program of China(2021YFC2300700);National Science and Technology Major Project(No.2018ZX10101004001005);National Natural Science Foundation of China(numbers 32070179).We thank Dr.Qinxue Hu(Wuhan Institute of Virology)and Dr.Yuchen Xia(Wuhan University)for help with materials.We thank Ding Gao from Center for Instrumental Analysis and Metrology at Wuhan Institute of Virology for his help with the Leica confocal microscope and the Operetta.; Infections of many viruses induce caspase activation to regulate multiple cellular pathways,including programmed cell death,immune signaling and etc.Characterizations of caspase cleavage sites and substrates are impor...; 关键词：CASPASE AEAD motif INHIBITOR VIRUS Cell death

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