AXONS

作品数：73被引量：220H指数：7
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相关领域：医药卫生生物学更多>>
相关作者：孙文婧更多>>
相关机构：空军军医大学（第四军医大学）普渡大学更多>>
相关期刊：《Science Bulletin》《Bioactive Materials》《Neuroscience Bulletin》《眼科学报》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划北京市自然科学基金更多>>
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Mechanism by which Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons
《Neural Regeneration Research》2025年第6期1816-1824,共9页Jiantao Cui Yueru Shen Zheng Song Dinggang Fan Bing Hu 
supported by the Research Funds of the Center for Advanced Interdisciplinary Science and Biomedicine of IHM,No.QYZD20220002;the National Natural Science Foundation of China,No.82071357;a grant from the Ministry of Science and Technology of China,No.2019YFA0405600 (all to BH)。
Rab5 is a GTPase protein that is involved in intracellular membrane trafficking. It functions by binding to various effector proteins and regulating cellular responses, including the formation of transport vesicles an...
关键词：axonal regeneration Mauthner cell nerve regeneration Rab5 ZEBRAFISH 
Metabolic reprogramming: a new option for the treatment of spinal cord injury
《Neural Regeneration Research》2025年第4期1042-1057,共16页Jiangjie Chen Jinyang Chen Chao Yu Kaishun Xia Biao Yang Ronghao Wang Yi Li Kesi Shi Yuang Zhang Haibin Xu Xuesong Zhang Jingkai Wang Qixin Chen Chengzhen Liang 
supported by the National Natural Science Foundation of China,No.82202681(to JW);the Natural Science Foundation of Zhejiang Province,Nos.LZ22H090003(to QC),LR23H060001(to CL).
Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they cause.Despite the ongoing development of various therapies for spinal cord injuries,their effectiveness ...
关键词：AXONS GLYCOLYSIS metabolic reprogramming metabolism mitochondria neural regeneration NEUROPROTECTION oxidative phosphorylation spinal cord injury therapy 
Growth hormone promotes the reconstruction of injured axons in the hypothalamo-neurohypophyseal system
《Neural Regeneration Research》2024年第10期2249-2258,共10页Kai Li Zhanpeng Feng Zhiwei Xiong Jun Pan Mingfeng Zhou Weizhao Li Yichao Ou Guangsen Wu Mengjie Che Haodong Gong Junjie Peng Xingqin Wang Songtao Qi Junxiang Peng 
supported by the Guangdong Basic and Applied Basic Research Foundation,Nos.2021A1515011371 (to JP),2021A1515110290 (to YO),2020A1515110564 (to XW);2023A 1 515010150 (to MZ);Science and Technology Planning Project of Guangzhou,No.202102020977 (to ZF);the National Natural Science Foundation of China,Nos.82201516 (to YO) and 81900709 (to ZF);President Foundation of Nanfang Hospital,Southern Medical University,Nos.2019C001 (to MZ),2019C016 (to XW), 2021C045 (to YO)。
Previous studies have shown that growth hormone can regulate hypothalamic energy metabolism, stress, and hormone release. Therefore, growth hormone has great potential for treating hypothalamic injury. In this study, ...
关键词：arginine vasopressin growth hormone hypothalamo-neurohypophyseal system HYPOTHALAMUS injury insulin-like growth factor 1 OXYTOCIN regeneration 
Neutrophil peptide 1 accelerates the clearance of degenerative axons during Wallerian degeneration by activating macrophages after peripheral nerve crush injury被引量：3
《Neural Regeneration Research》2024年第8期1822-1827,共6页Yuhui Kou Yusong Yuan Qicheng Li Wenyong Xie Hailin Xu Na Han 
supported by the National Natural Science Foundation of China,No.32371048(to YK);the Peking University People’s Hospital Research and Development Funds,No.RDX2021-01(to YK);the Natural Science Foundation of Beijing,No.7222198(to NH)。
Macrophages play an important role in peripheral nerve regeneration,but the specific mechanism of regeneration is still unclear.Our preliminary findings indicated that neutrophil peptide 1 is an innate immune peptide ...
关键词：axonal debris inflammatory factors MACROPHAGES neutrophil peptide 1 peripheral nerve injury peripheral nerve regeneration RAW 264.7 cells sciatic nerve Wallerian degeneration 
Mapping of individual sensory nerve axons from digits to spinal cord with the transparent embedding solvent system被引量：1
《Cell Research》2024年第2期124-139,共16页Yating Yi Youqi Li Shiwen Zhang Yi Men Yuhong Wang Dian Jing Jiayi Ding Qingjie Zhu Zexi Chen Xingjun Chen Jun-Liszt Li Yilong Wang Jun Wang Hanchuan Peng Li Zhang Wenjing Luo Jian Q.Feng Yongwen He Woo-Ping Ge Hu Zhao 
supported by a startup fund from the Chinese Institute for Brain Research to H.Z.and W.-P.G.,the National Natural Science Foundation of China(82101059 to Y.Y.);the Research Funding from West China School/Hospital of Stomatology Sichuan University(RCDWJS2022-11 to Y.Y.).
Achieving uniform optical resolution for a large tissue sample is a major challenge for deep imaging.For conventional tissue clearing methods,loss of resolution and quality in deep regions is inevitable due to limited...
关键词：EMBEDDING TRANSPARENT DIGIT 
Mechanism of Universal Quantum Computation in the Brain
《Journal of Applied Mathematics and Physics》2024年第2期468-474,共7页Aman Chawla Salvatore Domenic Morgera 
In this paper, the authors extend [1] and provide more details of how the brain may act like a quantum computer. In particular, positing the difference between voltages on two axons as the environment for ions undergo...
关键词：AXONS Quantum computation Metric perturbation DECOHERENCE Time-coded information 
Trick or treat?Does cancer fool Schwann cells by mimicking axons to promote metastasis into nerves?
《Neural Regeneration Research》2023年第8期1727-1727,共1页Peter Arthur-Farraj 
funded by a Clinical Research Career Development Fellowship from the Wellcome Trust(UK),206634/Z/17/Z。
The Schwann cell reaction to nerve injury,termed the repair program,is crucial to successful nerve regeneration.Over the last decade,substantial advances have been made in elucidating the underlying molecular mechanis...
关键词：NERVES invasion METASTASIS 
Chx10+V2a interneurons in spinal motor regulation and spinal cord injury被引量：3
《Neural Regeneration Research》2023年第5期933-939,共7页Wen-Yuan Li Ling-Xiao Deng Feng-Guo Zhai Xiao-Yu Wang Zhi-Gang Li Ying Wang 
supported by the National Natural Science Foundation of China,No. 81870977 (to YW);the Natural Science Foundation of Heilongjiang Province of China,No. JQ2021H004 (to YW);PhD research foundation of Mudanjiang Medicine College,No. 2021-MYBSKY-039 (to WYL);Fundamental Research Funds for Heilongjiang Provincial Universities,No. 2021-KYYWF-0469 (to WYL)。
Chx10-expressing V2 a(Chx10+V2 a) spinal interneurons play a large role in the excitatory drive of motoneurons. Chemogenetic ablation studies have demonstrated the essential nature of Chx10+V2 a interneurons in the re...
关键词：AXONS central nervous system central pattern generator Chx10 differentiation INTERNEURONS locomotion motor neurons PROPRIOSPINAL spinal cord injuries therapy transcription factor transplantation V2a neuron 
What we know about axons in Parkinson’s disease
《Aging Communications》2023年第1期20-28,共9页Weili Cai Tingyan Wu Weidong Le Xi Chen 
supported by funding from the Key Research and Development Program of Sichuan(2021YFS0382 to CX);the Medical Research Project of Jiangsu Commission of Health(M2022004 to CWL);Huai'an Natural Science Research Program(HAB202239 to CWL);the National Natural Science Foundation of China(General Program)(82271524 to LWD);the National Natural Science Foundation of China(Key Program)(32220103006 to LWD).
Tremendous research efforts have been made regarding the pathogenesis of Parkinson’s disease(PD).However,there are still no effective strategies to restore midbrain dopaminergic(mDA)innervation and prevent disease pr...
关键词：axon guidance axonal transport Parkinson’s disease light-sheet microscopy super-resolution microscopy 
Engineered neuronal microtissue provides exogenous axons for delayed nerve fusion and rapid neuromuscular recovery in rats
《Bioactive Materials》2022年第12期339-353,共15页Justin C.Burrell Suradip Das Franco A.Laimo Kritika S.Katiyar Kevin D.Browne Robert B.Shultz Vishal J.Tien Phuong T.Vu Dmitriy Petrov Zarina SAli Joseph M.Rosen D.Kacy Cullen 
The authors would like to thank Elizabeth Boyle for technical support.Financial support provided by the U.S.Department of Defense[CDMRP/JPC8-CRMRP W81XWH-16-1-0796(Cullen)&CDMRP/PRORP W81XWH-19-1-0867(Cullen&Das)];the Department of Veterans Affairs[BLR&D Merit Review I01-BX003748(Cullen)];the National Institutes of Health[R44-NS108869(Katiyar&Cullen);T32-EB005583(Shultz),TL1-TR001880(Burrell)];the Center for Undergraduate Research and Fellowships at the University of Pennsylvania.Opinions,interpretations,conclusions and recommendations are those of the author(s)and are not necessarily endorsed by the Department of Defense,the Department of Veterans Affairs,or the National Institutes of Health.
Nerve injury requiring surgical repair often results in poor functional recovery due to the inability of host axons to re-grow long distances and reform meaningful connections with the target muscle. While surgeons ca...
关键词：Nerve regeneration Neuromuscular injury Muscle preservation Tissue engineering Microtissue Axon fusion 
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