Trick or treat?Does cancer fool Schwann cells by mimicking axons to promote metastasis into nerves?  

作　　者：Peter Arthur-Farraj 

机构地区：[1]John Van Geest Centre for Brain Repair,Department of Clinical Neurosciences,University of Cambridge,Cambridge,UK

出　　处：《Neural Regeneration Research》2023年第8期1727-1727,共1页中国神经再生研究（英文版）

基　　金：funded by a Clinical Research Career Development Fellowship from the Wellcome Trust(UK),206634/Z/17/Z。

摘　　要：The Schwann cell reaction to nerve injury,termed the repair program,is crucial to successful nerve regeneration.Over the last decade,substantial advances have been made in elucidating the underlying molecular mechanisms in Schwann cells that lead to functional nerve repair.Moreover,the field has identified situations,such as aging and chronic denervation where these mechanisms go awry,paving the way for the development of therapeutic interventions(Arthur-Farraj and Coleman,2021;Cattin and Lloyd,2016;Jessen and Mirsky,2019).A recent article by Deborde et al.(2022)has demonstrated that unfortunately there is a downside to Schwann cells having such an efficient regeneration-promoting program;the promotion of tumor invasion of peripheral nerves.

关 键 词：NERVES invasion METASTASIS 

分 类 号：R73[医药卫生—肿瘤]