Involvement of Opioid Peptides in the Analgesic Effect of Spinal Cord Stimulation in a Rat Model of Neuropathic Pain  

作　　者：Fu-Jun Zhai Song-Ping Han Tian-Jia Song Ran Huo Xing-Yu Lan Rong Zhang Ji-Sheng Han 

机构地区：[1]Neuroscience Research Institute,Peking University,Beijing 100191,China [2]Department of Neurobiology,School of Basic Medical Sciences,Peking University,Beijing 100191,China [3]Key Laboratory for Neuroscience,Ministry of Education,National Health Commission,Peking University,Beijing 100191,China [4]Wuxi HANS Health Medical Technology Co.,Ltd.,Wuxi 214122,China [5]Department of Integration of Chinese and Western Medicine,School of Basic Medical Sciences,Peking University,Beijing 100191,China

出　　处：《Neuroscience Bulletin》2022年第4期403-416,共14页神经科学通报（英文版）

基　　金：supported by the National Key Research and Development Program of the Ministry of Science and Technology,China(2016YFC0105501,2019YFD1712000).

摘　　要：Spinal cord stimulation(SCS)-induced analgesia was characterized,and its underlying mechanisms were examined in a spared nerve injury model of neuropathic pain in rats.The analgesic effect of SCS with moderate mechanical hypersensitivity was increased with increasing stimulation intensity between the 20%and 80%motor thresholds.Various frequencies(2,15,50,100,10000 Hz,and 2/100 Hz dense-dispersed)of SCS were similarly effective.SCS-induced analgesia was maintained without tolerance within 24 h of continuous stimulation.SCS at 2 Hz significantly increased methionine enkephalin content in the cerebrospinal fluid.The analgesic effect of 2 Hz was abolished byμorκopioid receptor antagonist.The effect of 100 Hz was prevented by aκantagonist,and that of 10 kHz was blocked by any of theμ,δ,orκreceptor antagonists,suggesting that the analgesic effect of SCS at different frequencies is mediated by different endorphins and opioid receptors.

关 键 词：SCS ANALGESIA Opioid receptors METHIONINE-ENKEPHALIN DYNORPHIN ENDORPHINS 

分 类 号：R651.2[医药卫生—外科学]