A non-opioid pathway for dynorphin-caused spinal cord injury in rats  

作　　者：Yu Chen Liangbi Xiang Jun Liu Dapeng Zhou Hailong Yu Qi Wang Wenfeng Han Mingming Guo 

机构地区：[1]Department of Orthopedics,General Hospital of Shenyang Military Area Command of Chinese PLA,Shenyang 110016,Liaoning Province,China

出　　处：《Neural Regeneration Research》2012年第11期815-820,共6页中国神经再生研究（英文版）

基　　金：supported by the Science and Key Technology Research and Development Program of Liaoning Province, No. 2011225021, 2011225041

摘　　要：Intrathecal injection of dynorphin into rats via subarachnoid catheter induces damage to spinal cord tissue and motor function. Injection of the kappa opioid receptor antagonist nor-binaltorphine, or the excitatory amino acid N-methyl-D-aspartate receptor antagonist MK-801 into rats alleviated the pathological changes of dynorphin-caused spinal cord tissue injury and reduced the acid phosphatase activity in the spinal cord. The experimental findings indicate that there are opioid and non-opioid pathways for dynorphin-induced spinal cord injury, and that the non-opioid receptor pathway may be mediated by the excitatory amino acid N-methyl-D-aspartate receptor.Intrathecal injection of dynorphin into rats via subarachnoid catheter induces damage to spinal cord tissue and motor function. Injection of the kappa opioid receptor antagonist nor-binaltorphine, or the excitatory amino acid N-methyl-D-aspartate receptor antagonist MK-801 into rats alleviated the pathological changes of dynorphin-caused spinal cord tissue injury and reduced the acid phosphatase activity in the spinal cord. The experimental findings indicate that there are opioid and non-opioid pathways for dynorphin-induced spinal cord injury, and that the non-opioid receptor pathway may be mediated by the excitatory amino acid N-methyl-D-aspartate receptor.

关 键 词：spinal cord injury DYNORPHIN kappa opioid receptor antagonist N-methyI-D-aspartate receptor antagonist motor function acid phosphatase 

分 类 号：Q426[生物学—神经生物学] TQ464.7[生物学—生理学]