ACONITINE

作品数：40被引量：110H指数：7
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相关作者：王朝虹何毅钱忠直孙姝琦杜振霞更多>>
相关机构：公安部物证鉴定中心黑龙江省药品检验所北京化工大学成都中医药大学更多>>
相关期刊：《Medicinal Plant》《Chinese Journal of Integrative Medicine》《Acta Pharmacologica Sinica》《Science China Chemistry》更多>>
相关基金：国家自然科学基金河北省自然科学基金国家重点基础研究发展计划更多>>
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HBB contributes to individualized aconitine-induced cardiotoxicity in mice via interfering with ABHD5/AMPK/HDAC4 axis被引量：1
《Acta Pharmacologica Sinica》2024年第6期1224-1236,共13页Ya-juan Guo Jing-jing Yao Zhen-zhen Guo Ming Ding Kun-lin Zhang Qing-hong Shen Yu Li Shao-fang Yu Ting Wan Fu-ping Xu Ying Wang Xiao-xiao Qi Jin-jun Wu Jian-xin Chen Zhong-qiu Liu Lin-lin Lu 
supported by National Natural Science Foundation of China(82022074 and 82274196);the 2020 Guangdong Provincial Science and Technology Innovation Strategy Special Fund(Guangdong-Hong Kong-Macao Joint Lab,2020B1212030006);Key-Area Research and Development Program of Guangdong Province(2020B1111100004).
The root of Aconitum carmichaelii Debx.(Fuzi)is an herbal medicine used in China that exerts significant efficacy in rescuing patients from severe diseases.A key toxic compound in Fuzi,aconitine(AC),could trigger unpr...
关键词：ACONITINE CARDIOTOXICITY individual differences hemoglobin subunit beta nitrogen monoxide ABHD5/AMPK/HDAC4 axis 
Severe aconite poisoning successfully treated with veno-arterial extracorporeal membrane oxygenation:A case report
《World Journal of Clinical Cases》2024年第2期399-404,共6页Saeko Kohara Yoshito Kamijo Ryoko Kyan Ichiro Okada Eiju Hasegawa Soichiro Yamada Koichi Imai Asuka Kaizaki-Mitsumoto Satoshi Numazawa 
BACKGROUND Most species of aconite contain highly toxic aconitines,the oral ingestion of which can be fatal,primarily because they cause ventricular arrhythmias.We describe a case of severe aconite poisoning that was ...
关键词：Aconite poisoning Fatal arrhythmia Veno-arterial extracorporeal membrane oxygenation ACONITINE MESACONITINE Case report 
Neurotoxicity mechanism of aconitine in HT22 cells studied by microfluidic chip-mass spectrometry被引量：6
《Journal of Pharmaceutical Analysis》2023年第1期88-98,共11页Yingrui Zhang Shiyu Chen Fangfang Fan Ning Xu Xian-Li Meng Yi Zhang Jin-Ming Lin 
supported the National Natural Science Foundation of China(Grant Nos.:81973569,82130113,and 22034005);the National Key R&D Program of China(Grant No.:2021YFF0600700);the“Xinglin Scholars”Research Promotion Program of Chengdu University of Traditional Chinese Medicine(Grant No.:BSH2021009).
Aconitine,a common and main toxic component of Aconitum,is toxic to the central nervous system.However,the mechanism of aconitine neurotoxicity is not yet clear.In this work,we had the hypothesis that excitatory amino...
关键词：ACONITINE Neurotoxicity mechanism HT22 cells Excitatory amino acids Microfluidic chip-mass spectrometry 
Acute myocardial necrosis caused by aconitine poisoning:A case report被引量：1
《World Journal of Clinical Cases》2022年第33期12416-12421,共6页Yu-Ping Liao Li-Han Shen Li-Hua Cai Jie Chen Han-Quan Shao 
Supported by Dongguan Science and Technology of Social Development Program,No.202050715001213.
BACKGROUND Herbal medicine has a long history of use in the prevention and treatment of disease and is becoming increasingly popular globally.However,there are also widespread concerns about its safety.Among them,the ...
关键词：ACONITINE ECMO Myocardial necrosis Ventricular arrhythmia Herbal medicine Case report 
Ginsenoside Rg_(1)Reduces Cardiotoxicity While Increases Cardiotonic Effect of Aconitine in vitro
《Chinese Journal of Integrative Medicine》2022年第8期693-701,共9页XU Xin XIE Xiao-fang DONG Yan-hong ZHANG Hui-qiong PENG Cheng 
Supported by the National Natural Science Foundation of China(Nos.81630101 and 81891012);Department of Science and Technology of Sichuan Province(No.2018JZ0081);the Open Research Fund of Chengdu University of Traditional Chinese Medicine Key Laboratory of Systematic Research of Distinctive Chinese Medicine Resources in Southwest China(No.2020XSGG001);Special Project for the Central Government to Guide the Development of Local Science and Technology in Sichuan Province(No.20ZYKJCX0006)。
Objective To explore the synergic mechanism of ginsenoside Rg_(1)(Rg_(1))and aconitine(AC)by acting on normal neonatal rat cardiomyocytes(NRCMs)and pentobarbital sodium(PS)-induced damaged NRCMs.Methods The toxic,non-...
关键词：ACONITINE ginsenoside Rg_(1) compatibility ion channel pathway CARDIOMYOCYTES 
Inhibition of the INa/K and the activation of peak INa contribute to the arrhythmogenic effects of aconitine and mesaconitine in guinea pigs被引量：9
《Acta Pharmacologica Sinica》2021年第2期218-229,共12页Xiang-chong Wang Qing-zhong Jia Yu-lou Yu Han-dong Wang Hui-cai Guo Xin-di Ma Chun-tong Liu Xue-yan Chen Qing-feng Miao Bing-cai Guan Su-wen Su He-ming Wei Chuan Wang 
supported by the National Natural Science Foundation of China(NSFC,81773828,81770407,81903730);the Natural Science Foundation of Hebei Province(C2011206145,H2018206297,C2018206277,H2019423130);the Research Foundation of Education Bureau of Hebei Province(BJ2019037).
Aconitine(ACO),a main active ingredient of Aconitum,is well-known for its cardiotoxicity.However,the mechanisms of toxic action of ACO remain unclear.In the current study,we investigated the cardiac effects of ACO and...
关键词：ACONITINE MESACONITINE ARRHYTHMIA action potential Na+/K+pump current voltage-gated sodium channel current 
Acute Toxicity and Toxicokinetics of Tongguan Powder in Rats
《Medicinal Plant》2020年第6期94-97,103,共5页Qun FENG Xin LI Min XIAO Tao ZHAO Xianzhen WANG Fanbo JING Jingchun YAO 
Key Scientific and Technological Innovation Project of Shandong Province,China(2018CXGC1304).
[Objectives]To evaluate the acute toxicity and toxicokinetics of Tongguan Powder in rats,and provide references for clinical safe medication.[Methods]The classical acute toxicity test method was used,rats were given d...
关键词：Tongguan Powder ACONITINE Acute toxicity TOXICOKINETICS 
Energy pharmacology of aconite(Radix aconiti lateralis reparata)
《Asian Toxicology Research》2020年第2期71-80,共10页Yan Liu Rui-Ping Li Zhu Wang Xi Sun Han-Fei Shi Wan-Sen Sun 
Objective:To study the energy pharmacology of aconite(Radix aconiti lateralis reparata).Methods:Literature induction method was applied to study the energy properties,energy pharmacological connotation,and energy phar...
关键词：Aconite(Radix aconiti lateralis reparata) ENERGY PHARMACOLOGY Hot ENERGY Four natures of DRUGS ACONITINE 
Real-time toxicity prediction of Aconitum stewing system using extractive electrospray ionization mass spectrometry被引量：9
《Acta Pharmaceutica Sinica B》2020年第5期903-912,共10页Zi-Dong Qiu Jin-Long Chen Wen Zeng Ying Ma Tong Chen Jin-Fu Tang Chang-Jiang-Sheng Lai Lu-Qi Huang 
supported by the National Natural Science Foundation of China(No.81603293);Young Elite Scientist Sponsorship Program by China Association for Science and Technology(No.CACM-2018-QNRC1-04,China);the Fundamental Research Funds for the Central Public Welfare Research Institutes(No.ZZ13-YQ-090,China);Key Project at Central Government Level:The ability establishment of sustainable use for valuable Chinese medicine resources(No.2060302,China)
Due to numerous obstacles such as complex matrices,real-time monitoring of complex reaction systems(e.g.,medicinal herb stewing system)has always been a challenge though great values for safe and rational use of drugs...
关键词：Real-time extractive electrospray ionization mass spectrometry Toxic alkaloids Data mining ACONITINE Aconitum--meat stewing system Toxicity prediction 
Research progress of aconitine toxicity and forensic analysis of aconitine poisoning被引量：8
《Forensic Sciences Research》2020年第1期25-31,共7页Xiangting Gao Jun Hu Xincai Zhang Yuanyi Zuo Yun Wang Shaohua Zhu 
This study was supported by the National Natural Science Foundation of China [grant number 81571848];the Priority Academic Program Development of Jiangsu Higher Education Institutions.
Chinese herbal medicines have been extensively used in China and other countries for cen-turies.Aconitine,a diterpenoid alkaloid extracted from Aconitum plants,has anti-inflamma-tory and analgesic activities,but can a...
关键词：Forensic SCIENCES ACONITINE TOXIC effects METABOLIC CHARACTERISTICS 
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