Research progress of aconitine toxicity and forensic analysis of aconitine poisoning  

作　　者：Xiangting Gao Jun Hu Xincai Zhang Yuanyi Zuo Yun Wang Shaohua Zhu 

机构地区：[1]Department of Forensic Medicine,Soochow University,Suzhou,China [2]Laboratory of Biomedical Technology,Jiangsu Vocational College of Medicine,Yancheng,China [3]Department of Forensic Sciences,Binhai People's Hospital,Yancheng,China

出　　处：《Forensic Sciences Research》2020年第1期25-31,共7页法庭科学研究（英文）

基　　金：This study was supported by the National Natural Science Foundation of China [grant number 81571848];the Priority Academic Program Development of Jiangsu Higher Education Institutions.

摘　　要：Chinese herbal medicines have been extensively used in China and other countries for cen-turies.Aconitine,a diterpenoid alkaloid extracted from Aconitum plants,has anti-inflamma-tory and analgesic activities,but can also induce severe arrhythmia and neurotoxicity.Aconitine poisoning accidents caused by misuse,suicide,or homicide have been reported in recent years.In China,fatal aconitine poisoning can occasionally happen on account of acci-dental ingestion of some wild plants or consumption of herbal decoction made from the roots of Aconitum plants.However,it is rather difficult for forensic experts to find the specific results in present forensic autopsy of aconitine-induced death.To further clarify its potential risk following the widespread application of aconitine,toxicological characteristics and pharmacokinetics of aconitine are reviewed.Moreover,gastrointestinal,neurological,and car-diovascular symptoms were observed frequently in aconitine poisoning cases.In addition,the review also aims at providing some convincing evidences for forensic experts to identify unexplained death with postmortem examination.

关 键 词：Forensic SCIENCES ACONITINE TOXIC effects METABOLIC CHARACTERISTICS 

分 类 号：D919.4[医药卫生—法医学]