TOXICOKINETICS

作品数：12被引量：5H指数：1
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相关领域：医药卫生更多>>
相关作者：陶长戈徐晓珍宣尧仙顾利强张升更多>>
相关机构：成都中医药大学浙江省医学科学院南方医科大学更多>>
相关期刊：《Medicinal Plant》《Acta Pharmacologica Sinica》《Science China Chemistry》《Environment & Health》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金更多>>
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Differences in Toxicokinetics and Maternal Transfer between Lipophilic and Proteinophilic Halogenated Organic Pollutants in Laying Hens
《Environment & Health》2024年第10期712-720,共9页Xiao-Jun Luo Qun-Jie Feng Chu-Hong Zhu Xi Chen Peng-Peng Chen Yan-Hong Zeng Bi-Xian Mai 
funded by the National Nature Science Foundation of China(Nos.U23A2056,42277267,42321003);Guangdong Major Project of Basic and Applied Basic Research(2023B0303000007);Guangdong Foundation for the Program of Science and Technology Research(Nos.2023B1212060049);This is a contribution No.IS-3527 from GIGCAS.
In this study,we conducted exposure experiments on egg-laying hens to explore the toxicokinetics and maternal transfer characteristics of lipophilic and proteinophilic halogenated organic pollutants(HOPs).The lipophil...
关键词：halogenated organic pollutants laying hens TOXICOKINETIC maternal transfer 
Dual mass spectrometry imaging and spatial metabolomics to investigate the metabolism and nephrotoxicity of nitidine chloride
《Journal of Pharmaceutical Analysis》2024年第7期1011-1023,共13页Shu Yang Zhonghua Wang Yanhua Liu Xin Zhang Hang Zhang Zhaoying Wang Zhi Zhou Zeper Abliz 
supported by the National Natural Science Foundation of China(Grant No.:21927808);the National Key Research and Development Program of China(Grant No.:2017YFC1704006).
Evaluating toxicity and decoding the underlying mechanisms of active compounds are crucial for drug development.In this study,we present an innovative,integrated approach that combines air flowassisted desorption elec...
关键词：Nitidine chloride NEPHROTOXICITY Mass spectrometry imaging Spatial metabolomics TOXICOKINETICS 
Tumor-targeting intravenous lipid emulsion of paclitaxel:Characteristics,stability,toxicity,and toxicokinetics被引量：1
《Journal of Pharmaceutical Analysis》2022年第6期901-912,共12页Jun Ye Lin Li Jiye Yin Hongliang Wang Renjie Li Yanfang Yang Yongbiao Guan Xuejun Xia Yuling Liu 
supported by the National Science and Technology Major Project of China(Grant No.:2018ZX09711001);Beijing Nova Program(Grant No.:Z211100002121127);Beijing Natural Science Foundation(Grant No.:L212059);Fundamental Research Funds for the Central Universities(Grant No.:3332021101);CAMS Innovation Fund for Medical Sciences(CIFMS,Grant No.:2022-I2M-JB-011).
Lipid nanoemulsions are promising nanodrug delivery carriers that can improve the efficacy and safety of paclitaxel(PTX).However,no intravenous lipid emulsion of PTX has been approved for clinical treatment,and system...
关键词：Nanodrug delivery systems Lipid emulsion PACLITAXEL Colloidal Stability TOXICOKINETICS 
Acute Toxicity and Toxicokinetics of Tongguan Powder in Rats
《Medicinal Plant》2020年第6期94-97,103,共5页Qun FENG Xin LI Min XIAO Tao ZHAO Xianzhen WANG Fanbo JING Jingchun YAO 
Key Scientific and Technological Innovation Project of Shandong Province,China(2018CXGC1304).
[Objectives]To evaluate the acute toxicity and toxicokinetics of Tongguan Powder in rats,and provide references for clinical safe medication.[Methods]The classical acute toxicity test method was used,rats were given d...
关键词：Tongguan Powder ACONITINE Acute toxicity TOXICOKINETICS 
Toxicokinetics and the related metabolites in rainbow trout(Oncorhynchus mykiss) after exposure to decabromodiphenyl ether被引量：1
《Science China Chemistry》2010年第11期2379-2386,共8页FENG ChengLian,XU YiPing,ZHA JinMiao,LUO Qian,SHAN XiaoQuan & WANG ZiJian State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China 
supported by the National Basic Research Program of China (2009CB421605);the National Natural Science Foundation of China (20737003 & 20877089)
Decabromodiphenyl ether(BDE209) is poorly absorbed by mammals,and little information is available on the toxicokinetics of BDE209 and its metabolites in fish.In the present study,rainbow trout(Oncorhynchus mykiss) wer...
关键词：decabromodiphenyl ether(BDE209) polybrominated DIPHENYL ethers(PBDEs) methoxylated brominated DIPHENYL ethers(MeO-BDEs) TOXICOKINETICS RAINBOW TROUT 
Effects of nanoscale quantum dots in male Chinese loaches (Misgurnus anguillicaudatus):Estrogenic interference action,toxicokinetics and oxidative stress被引量：2
《Science China Chemistry》2009年第10期1683-1690,共8页HongCheng Li  WenRu Luo  Yong Tao  Yuan Wu  XueFei Lv  QunFang Zhou GuiBin Jiang 
Supported by the State High Tech Development (Grant No. 2006AA06Z424);the National Natural Science Foundation of China (Grant No. 20537020);Chinese Academy of Sciences (Grant No. KZCX2-YW-420-21)
Quantum dots (QDs) have more and more attention as a novel example of nanocrystals due to their unique fluorescent characteristics. Recently, the toxicity and the potential environmental effects of QDs have become a r...
关键词：quantum DOT ESTROGENIC effect TOXICOKINETICS OXIDATIVE stress 
In vivo and in vitro chondrotoxicity of ciprofloxacin in juvenile rats被引量：1
《Acta Pharmacologica Sinica》2004年第10期1262-1266,共5页PingLI Neng-nengCHENG Bin-yanCHEN Yong-mingWANG 
ProjectsupportedbytheJRCCFund.
AIM: To study the relationship between chondrotoxicity and toxicokinetics of ciprofloxacin (CPFX). METHODS: Rats, 4-week old, were treated with CPFX 0, 400, 800, and 1200 mg/kg ig once daily on seven consecutive days....
关键词：CIPROFLOXACIN knee joints articular cartilage GLYCOSAMINOGLYCANS cell survival TOXICOKINETICS juvenile rats 
Toxicokinetics in Japan
《中国药理学与毒理学杂志》2002年第6期412-413,共2页HakuH 
The word ‘toxicokinetics’ is a comparatively new word,but it was being generally practiced in Japanese pharmaceutical industry over 6 years ago.Note for guidance on toxicokinetics(ICH S3A):the assessment of systemic...
关键词：毒物动力学 日本 研究进展 
Toxicokinetics,distribution and excretion of fumalin in rats
《中国药理学与毒理学杂志》2002年第6期414-414,共1页BaiXG ChenG 
Toxicokinetics study of fumalin was performed with ^14C labeled compound.It showed that the data were fitted to a two-compartment model.Radioactivity distribution in organs and tissues and its excretion in urine and f...
关键词：毒物动力学 分布 分泌 
Diazinon Toxicokinetics, Tissue Distribution and Anticholinesterase Activity in the Rat
《Biomedical and Environmental Sciences》1996年第4期359-369,共11页H. X. WU CL. EVREUX-GROS AND J. DESCOTESa (Department of Pharmacology and Medical Toxicology, INSERM U80,LYON-RTH Laennec Faculty of Medicine, 69008 Lyon France) 
The toxicokinetics, tissue distribution, and anticholinesteruse (antiChE ) activity of diazinon were investigated in the rat. Plasma concentrations most adequately fitted a two-compartment open model after iv adminis...
关键词：ACTIVITY Diazinon Toxicokinetics Tissue Distribution and Anticholinesterase Activity in the Rat 
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