Diazinon Toxicokinetics, Tissue Distribution and Anticholinesterase Activity in the Rat  

作　　者：H. X. WU CL. EVREUX-GROS AND J. DESCOTESa (Department of Pharmacology and Medical Toxicology, INSERM U80,LYON-RTH Laennec Faculty of Medicine, 69008 Lyon France) 

出　　处：《Biomedical and Environmental Sciences》1996年第4期359-369,共11页生物医学与环境科学（英文版）

摘　　要：The toxicokinetics, tissue distribution, and anticholinesteruse (antiChE ) activity of diazinon were investigated in the rat. Plasma concentrations most adequately fitted a two-compartment open model after iv administration of 10 mg/kg and a one-compartment model after oral administration of 80 mg/kg. Diazinon elimination half-life following iv and oral dosing was 4.70 and 2.86 h, respectively. The oral bioavailabllity was found to be low (35.5%). Hepatic extraction ratios after iv administration of 5 or 10 mgThe toxicokinetics, tissue distribution, and anticholinesteruse (antiChE ) activity of diazinon were investigated in the rat. Plasma concentrations most adequately fitted a two-compartment open model after iv administration of 10 mg/kg and a one-compartment model after oral administration of 80 mg/kg. Diazinon elimination half-life following iv and oral dosing was 4.70 and 2.86 h, respectively. The oral bioavailabllity was found to be low (35.5%). Hepatic extraction ratios after iv administration of 5 or 10 mg

关 键 词：ACTIVITY Diazinon Toxicokinetics Tissue Distribution and Anticholinesterase Activity in the Rat 

分 类 号：R992[医药卫生—毒理学] S481.1[医药卫生—药学]