ACTIVITY

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Understanding activity of butyrate at a cellular level
《Neural Regeneration Research》2025年第8期2323-2324,共2页Prapti Chakraborty Angela S.Laird 
supported by an NHMRC Project Grant GNT2012895(to ASL)。
Butyrate is a short-chain fatty acid of four carbons in length that is a by-product produced by the microbial fermentation of dietary fiber and undigested carbohydrates within the colon.Over the years,butyrate has att...
关键词：CARBONS BUTYRATE FIBER 
PathActMarker:an R package for inferring pathway activity of complex diseases
《Frontiers of Computer Science》2025年第3期123-124,共2页Xingyi LI Jun HAO Zhelin ZHAO Junming LI Xingyu LIAO Min LI Xuequn SHANG 
supported in part by the National Natural Science Foundation of China(Grant No.62202383);Guangdong Basic and Applied Basic Research Foundation(No.2024A1515012602);the National Key Research and Development Program of China(No.2022YFD1801200).
1 Introduction The process of complex diseases is closely linked to the disruption of key biological pathways,it is crucial to identify the dysfunctional pathways and quantify the degree of dysregulation at the indivi...
关键词：pathway activity DYSREGULATION complex diseases biological pathways disruption key biological pathwaysit identify dysfunctional pathways 
Investigation of conformational changes of cathepsin B as a feasibility assessment for NaCl reduction in Jinhua ham
《Food Science and Human Wellness》2025年第2期429-438,共10页Shiqi Hu Guanghong Zhou Xinglian Xu Wangang Zhang Chunbao Li 
supported by the National Natural Science Foundation of China(31972097);Jiangsu Key Research and Development Plan(Modern Agriculture)(BE2020302);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(24KJB550003);2024 Huaiyin Institute of Technology Talent Recruitment Research Startup Fund Project(Z301B24521)。
To regulate the sodium chloride content in Jinhua ham,the impact of NaCl on the activity and conformation of cathepsin B was investigated using spectroscopy and computational methods.The results showed that the activi...
关键词：Protein conformation Cathepsin B activity Jinhua ham Molecular docking Molecular dynamics 
Structurally diverse sesquiterpenoids with anti-MDR cancer activity from Penicillium roqueforti
《Chinese Journal of Natural Medicines》2025年第4期504-512,共9页Shuyuan Mo Nanjin Ding Zhihong Huang Jun Yao Weiguang Sun Jianping Wang Yonghui Zhang Zhengxi Hu 
supported by the National Natural Science Foundation of China(Nos.82273811,32470417,and U22A20380);the National Program for Support of Top-notch Young Professionals(No.0106514050);the Hubei Provincial Natural Science Foundationof China(No.2024AFA028);the National Key R&D Program of China(No.2021YFA0910500);the Science and Technology Major Project of Hubei Province(Nos.2021ACA012 and 2024BCB021);the Chinese Medicine Research Foundation of the Health Commission of Hubei Province(No.ZY2025Z013)。
Five novel nor-eremophilane-type sesquiterpenoids,peniroqueforins E–H and J(1–4 and 7),two new eremophilane-type sesquiterpenoids,peniroqueforins I and K(5 and 8),and a new eudesmane-type sesquiterpenoid,peniroquefo...
关键词：Penicillium roqueforti SESQUITERPENOIDS Nor-sesquiterpenoids Anti-MDR cancer activity 
Study on the Immune Activity of Mice In Vitro and In Vivo with Nano-Material Adjuvant
《Journal of Clinical and Nursing Research》2025年第4期356-362,共7页Qiran Wang 
This paper investigates the effects of graphene quantum dots and mesoporous silica as nanomaterial adjuvants on immune activity in mice both in vitro and in vivo.The two materials have distinct properties;graphene qua...
关键词：Graphene quantum dots Mesoporous silica Nanomaterial adjuvant Immune activity Immune regulation 
Actin polymerization regulates the osteogenesis of hAsCs by influencingα-tubulin expression and Eg5 activity
《Genes & Diseases》2025年第2期29-32,共4页Tingyu Fan Wenqing Liu Rongmei Qu Jinhui Zhu Yulian Shi Jiaxuan Liu Xiangtian Li Zhitao Zhou Yunbing Chang Jun Ouyang Jingxing Daia 
supported by the National Key R&D Program of China (No.2022YFF1202603);the President's Foundation of TCM-Integrated Hospital of Southern Medical University (No.1202103001).
Seed cells,scaffold materials,and growth factors constitute the three fundamental components of bone tissue engineering.In recent years,human adipose-derived stem cells(hASCs)have emerged as promising candidate cells ...
关键词：Eg5 engineering. CONSTITUTE 
Hike
《初中生必读》2025年第4期44-45,共2页赵博言 郑全新(指导) 
I would like to share an interesting thing about the hike①.It is not only a simple outdoor walk,but also an educational practical activity.When my classmates and I learned that we would have a hike on Friday,we were ...
关键词：educational activity EXCITEMENT PLANNING hike WORRY 
Suppressor of cytokine signaling 2 modulates regulatory T cell activity to suppress liver hepatocellular carcinoma growth and metastasis
《World Journal of Gastroenterology》2025年第13期116-137,共22页Xi Lan Heng Zhang Ze-Yan Chen Jing Wang Shi-Chang Zhang Qing Li Juan-Yu Ke Wei Wei Rong Huang Xi Tang Si-Ping Chen Ting-Ting Huang Yi-Wen Zhou 
Supported by Wu Jieping Medical Foundation,No.320.6750.2021-06-30;Guangdong Basic and Applied Basic Research Foundation,No.2019A1515110120;National Natural Science Foundation of China,No.82002974。
BACKGROUND Liver hepatocellular carcinoma(LIHC)is a highly aggressive cancer with poor prognosis due to its complex tumor microenvironment(TME)and immune evasion.Regulatory T cells(Tregs)play a critical role in tumor ...
关键词：Liver hepatocellular carcinoma Regulatory T cells Suppressor of cytokine signaling 2 Immune microenvironment Tumor metastasis 
Hymoins A–C,three unusual polycyclic polyprenylated acylphloroglucinols with lipid-lowering activity from Hypericum monogynum
《Chinese Chemical Letters》2025年第3期411-414,共4页Chunmao Yuan Yanrong Zeng Lei Huang Yu Mou Jun Jin Ping Yi Yanmei Li Xiaojiang Hao 
financially supported by the National Natural Science Foundation of China(Nos.32270413,82060631,82160808,and 82360035);the Science and Technology Department of Guizhou Province(Nos.QKHJC 2020–1Z076,QKHJC-ZK[2023]YB156,QKHJC-ZK[2021]YB569,and QKHPTRC[2020]5008);Excellent Young Talents Plan of Guizhou Medical University(2023,No.106);the 13thbatch of outstanding young scientific and technological talents in Guizhou Province(No.QKHPTRC[2021]5633);Guizhou Science and Technology Innovation Talent Team(No.QKHPTRC–CXTD[2022]007);High-level Innovative Talents in Guizhou Province(Thousand Levels of Talent for Chunmao Yuan in 2018);the project of State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University(Nos.FAMP202102K and QJJ[2023]113)。
Hymoins A–C(1–3),three unusual polycyclic polyprenylated acylphloroglucinols(PPAPs)were isolated from the flowers of Hypericum monogynum.Hymoin A features the first intriguing 6/5/5/5/7 pentacyclic caged PPAP.Hymoin...
关键词：Hypericum monogynum Polycyclic polyprenylated ACYLPHLOROGLUCINOLS Structure elucidation Lipid-lowering activity Mechanistic study 
Mitophagy Promotes Hair Regeneration by Activating Glutathione Metabolism
《Research》2025年第1期854-869,共16页Dehuan Wang Jingwei Jiang Mengyue Wang Ke Li Huan Liang Nian'ou Wang Weiwei Liu Miaomiao Wang Siyi Zhou Man Zhang Yang Xiao Xinyu Shen Zeming Li Wang Wu Xia Lin Xiao Xiang Qiaoli Xie Wanqian Liu Xun Zhou Qu Tang Wei Zhou Li Yang Cheng-Ming Chuong Mingxing Lei 
supported by the National Key Research and Development Program of China(2023YFC2508200);the National Natural Science Foundation of China(82373509,82003384,and 82203960);Fundamental Research Funds for the Central Universities(2022CDJYGRH-003 and 2023CDJKYJH066);the Natural Science Foundation of Chongqing(CSTB2023JXJL-YFX0028);Chongqing Talents:Exceptional Young Talents Project(cstc2021ycjh-bgzxm0197);Inheritance and Innovation Team of TCM Treatment of Immune Diseases,Scientific Research Foundation from Chongqing University(02210011044110);Research Horizontal Projects of Chongqing University(H20231432 and H20230936),China;C.-M.C.is supported by a research contract(GR1035751)between USC and CMU and US NIH grant R37 AR060306.
Mitophagy maintains tissue homeostasis by self-eliminating defective mitochondria through autophagy.How mitophagy regulates stem cell activity during hair regeneration remains unclear.Here,we found that mitophagy prom...
关键词：mitochondrial activity glutathione metabolism probetransmission electron microscopyand tissue homeostasis hair regeneration stem cell activity 
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