Modulating the Pronociceptive Effect of Sleep Deprivation:A Possible Role for Cholinergic Neurons in the Medial Habenula  

作　　者：Xiang-Sha Yin Bai-Rong Chen Xi-Chun Ye Yun Wang 

机构地区：[1]Department of Neurobiology,School of Basic Medical Sciences and Neuroscience Research Institute,Peking University,Beijing,100083,China [2]Key Lab for Neuroscience,Ministry of Education of China and National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs,Peking University,Beijing,100083,China [3]PKU-IDG/McGovern Institute for Brain Research,Peking University,Beijing,100871,China [4]Department of Human Anatomy,Histology and Embryology,Institute of Basic Medical Sciences Chinese Academy of Medical Sciences,School of Basic Medicine Peking,Union Medical College,Beijing,100730,China

出　　处：《Neuroscience Bulletin》2024年第12期1811-1825,共15页神经科学通报(英文版)

基　　金：supported by grants from the Ministry of Science and Technology of China(2021ZD0203204);the National Natural Science Foundation of China(32030052 and 31530028).

摘　　要：Sleep deprivation has been shown to exacerbate pain sensitivity and may contribute to the onset of chronic pain,yet the precise neural mechanisms underlying this association remain elusive.In our study,we explored the contribution of cholinergic neurons within the medial habenula(MHb)to hyperalgesia induced by sleep deprivation in rats.Our findings indicate that the activity of MHb cholinergic neurons diminishes during sleep deprivation and that chemogenetic stimulation of these neurons can mitigate the results.Interestingly,we did not find a direct response of MHb cholinergic neurons to pain stimulation.Further investigation identified the interpeduncular nucleus(IPN)and the paraventricular nucleus of the thalamus(PVT)as key players in the pro-nociceptive effect of sleep deprivation.Stimulating the pathways connecting the MHb to the IPN and PVT alleviated the hyperalgesia.These results underscore the important role of MHb cholinergic neurons in modulating pain sensitivity linked to sleep deprivation,highlighting potential neural targets for mitigating sleep deprivation-induced hyperalgesia.

关 键 词：Medial habenula CHOLINERGIC Sleep deprivation Pronociceptive effect HYPERALGESIA 

分 类 号：R338[医药卫生—人体生理学]