PARKINSONISM

作品数:51被引量:287H指数:8
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相关领域:医药卫生更多>>
相关作者:王涛张巧俊王爽吴仲恒刘健更多>>
相关机构:环境与疾病相关基因教育部重点实验室西安交通大学大理大学中国医学科学院北京协和医学院更多>>
相关期刊:《Acta Pharmacologica Sinica》《Journal of Bio-X Research》《Pharmacology & Pharmacy》《Phenomics》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>
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Correction: SHP2-mediated mitophagy boosted by lovastatin in neuronal cells alleviates parkinsonism in mice
《Signal Transduction and Targeted Therapy》2025年第1期475-475,共1页Wen Liu Meijing Wang Lihong Shen Yuyu Zhu Hongyue Ma Bo Liu Liang Ouyang Wenjie Guo Qiang Xu Yang Sun 
Correction to:Signal Transduction and Targeted Therapy https://doi.org/10.1038/s41392-021-00474-x,published online 29 January 2021 In the process of collating the raw data,the authors noticed an inadvertent mistakes o...
关键词:LOVASTATIN SHP2 BOOST 
Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism
《Neural Regeneration Research》2025年第1期93-106,共14页Yujie Yang Xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao Mei Tian Jian Wang Fengtao Liu Chuantao Zuo 
supported by the Research Project of the Shanghai Health Commission,No.2020YJZX0111(to CZ);the National Natural Science Foundation of China,Nos.82021002(to CZ),82272039(to CZ),82171252(to FL);a grant from the National Health Commission of People’s Republic of China(PRC),No.Pro20211231084249000238(to JW);Medical Innovation Research Project of Shanghai Science and Technology Commission,No.21Y11903300(to JG).
Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of parkinsonism....
关键词:aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease PARKINSONISM positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2 
Motor cortical circuit adaptations in parkinsonism
《Neural Regeneration Research》2024年第10期2107-2108,共2页Hong-Yuan Chu 
supported in part by the research grant from the National Institute of Neurological Disorders and Stroke,No.R01NS 12137 (to HYC);funded in whole or in part by Aligning Science Across Parkinson's (No.ASA P-0205 720) through the Michael J.Fox Foundation for Parkinson's Research (MJFF)。
Parkinson's disease is a chronic and progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta,which leads to the featured motor impairment of parki...
关键词:PARKIN IMPAIRMENT RIGIDITY 
A Cysteinyl-tRNA Synthetase Mutation Causes Novel Autosomal-Dominant Inheritance of a Parkinsonism/Spinocerebellar-Ataxia Complex
《Neuroscience Bulletin》2024年第10期1489-1501,共13页Han-Kui Liu Hong-Lin Hao Hui You Feng Feng Xiu-Hong Qi Xiao-Yan Huang Bo Hou Chang-Geng Tian Han Wang Huan-Ming Yang Jian Wang Rui Wu Hui Fang Jiang-Ning Zhou Jian-Guo Zhang Zhen-Xin Zhang 
supported by the NIH-NIA Research Project (R21AG036454);the National Key R&D Program of China (2016YFC0901500);CAMS Innovation Fund for Medical Sciences (2016-12M-1-004);the National Key R&D Program of China (2016YFC1305900);the National Natural Science Foundation of China (3203004);the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02030001);Shenzhen Municipal of Government of China (JCYJ20170412153248372 and JCYJ20180507183615145).
This study aimed to identify possible pathogenic genes in a 90-member family with a rare combination of multiple neurodegenerative disease phenotypes,which has not been depicted by the known neurodegenerative disease....
关键词:PARKINSONISM Spinocerebellar ataxia CARS gene 
Synchronous Dosing of Levodopa with Quercetin Enhances Therapeutic Efficacy and Mitigates Apoptotic Events in Experimental Parkinsonism
《Journal of Bio-X Research》2024年第3期105-113,共9页Arya Indulekha Sureshkumar Chempakam Biju Latha Akshara Pradeep Renjini Ambika Padmanabhan Rajesh Ramachandran 
Parkinson’s disease(PD)affects millions of people annually across the globe and is primarily managed through dopamine replacement therapy employing levodopa(L-DOPA),which is still the preferred gold standard.Prolonge...
关键词:natural synthetic compounds therapeutic efficacy dopamine replacement therapy LEVODOPA Parkinsons disease synchronous dosing QUERCETIN parkinson s disease pd affects 
Long COVID:From olfactory dysfunctions to viral Parkinsonism
《World Journal of Otorhinolaryngology-Head and Neck Surgery》2024年第2期137-147,共11页Sanyukta Pandey Vibha Bapat Jancy Nixon Abraham Nixon M.Abraham 
DBT/Wellcome Trust India Alliance senior,Grant/Award Number:IA/S/22/2/506517;Ramalingaswami Fellowship,Department of Biotechnology,Govt.of India,Grant/Award Number:BT/RLF/Re-entry/45/2014;Council of Scientific and Industrial Research,India。
Neurological and psychiatric complications continue to be a public health concern in long coronavirus disease 2019(COVID-19).This varies from olfactory dysfunctions such as parosmia to cognitive and emotional challeng...
关键词:long COVID NEURODEGENERATION NEUROTROPISM olfactory dysfunctions viral parkinsonism 
Retraction Note:Asiaticoside,a trisaccaride triterpene induces biochemical and molecular variations in brain of mice with parkinsonism
《Translational Neurodegeneration》2024年第1期696-696,共1页Uvarajan Sampath Vanisree Arambakkam Janardhanam 
Retraction Note:Transl Neurodegener 2,23(2013)https://doi.org/10.1186/2047-9158-2-23 The Editor-in-Chief has retracted this article because concerns have been raised regarding some of the images presented in the Figur...
关键词:raised molecular PRESENTED 
PLA2G6-related parkinsonism:clinical and genetic characteristics of 6 cases and literature review
《China Medical Abstracts(Internal Medicine)》2024年第1期62-63,共2页谢曼青 
Objective To elucidate the clinical and genetic characteristics of PLA2G6-related parkinsonism.Methods The clinical,imaging and genetic data of 6patients with PLA2G6-related parkinsonism admitted to Peking Union Medic...
关键词:CLINICAL admitted PLA2 
External anal sphincter electromyography in multiple system atrophy:implications for diagnosis,clinical correlations,and novel insights into prognosis被引量:2
《Neural Regeneration Research》2023年第9期1903-1907,共5页Massimiliano Todisco Giuseppe Cosentino Enrico Alfonsi 
supported by the Italian Ministry of Health (’Ricerca Corrente’2020-2021)(to MT)。
Multiple system atrophy is a sporadic,progressive,adult-onset,neurodegenerative disorder characte rized by autonomic dysfunction symptoms,parkinsonian features,and cerebellar signs in va rious combinations.An early di...
关键词:bowel dysfunction differential diagnosis DYSAUTONOMIA ELECTROPHYSIOLOGY multiple system atrophy Onuf’s nucleus degeneration PARKINSONISM Parkinson’s disease prognostic prediction urogenital symptoms 
Inhibiting von Hippel‒Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism
《Acta Pharmacologica Sinica》2023年第5期940-953,共14页Jie Shen Qian Zha Qian-hua Yang Yue-qian Zhou Xiao Liang Ying-jie Chen Gui-xia Qi Xiao-jin Zhang Wen-bing Yao Xiang-dong Gao Song Chen 
supported by the National Natural Science Foundation of China(Nos.82173728,81872850,82073755,81673435);the"Double First-Class"University Project(No.CPU2018GF08);Qing Lan Project of Jiangsu Province and PAPD(A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions).
Dopaminergic neuron degeneration is a hallmark of Parkinson’s disease(PD).We previously reported that the inactivation of von Hippel‒Lindau(VHL)alleviated dopaminergic neuron degeneration in a C.elegans model.In this...
关键词:Parkinson’s disease von Hippel‒Lindau Dishevelled-2 peptide MPTP MPP^(+) 
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