LOVASTATIN

作品数：77被引量：227H指数：8
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相关领域：医药卫生更多>>
相关作者：糜漫天张乾勇张雪玲金宗濂文镜更多>>
相关机构：第三军医大学北京联合大学浙江大学兰州军区联勤部更多>>
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相关基金：国家自然科学基金云南省自然科学基金国家科技支撑计划国家高技术研究发展计划更多>>
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Correction: SHP2-mediated mitophagy boosted by lovastatin in neuronal cells alleviates parkinsonism in mice
《Signal Transduction and Targeted Therapy》2025年第1期475-475,共1页Wen Liu Meijing Wang Lihong Shen Yuyu Zhu Hongyue Ma Bo Liu Liang Ouyang Wenjie Guo Qiang Xu Yang Sun 
Correction to:Signal Transduction and Targeted Therapy https://doi.org/10.1038/s41392-021-00474-x,published online 29 January 2021 In the process of collating the raw data,the authors noticed an inadvertent mistakes o...
关键词：LOVASTATIN SHP2 BOOST 
Lovastatin modulation of YAP/TAZ signaling on cardiomyocyte autophagy and mitochondrial damage in myocardial I/R injury
《BIOCELL》2024年第10期1489-1501,共13页KAITIAN ZHANG MINGZHU LI JIANPING ZHANG JINFENG LI KUNLANG LI HUANQIAN LU JINYAN LV 
Objective:Studies have demonstrated that administering statins promptly following myocardial ischemia/reperfusion(MI/R)can confer cardioprotective benefits.This study investigates whether Lovastatin can modulate the Y...
关键词：MI/R injury LOVASTATIN YAP/TAZ signaling pathway AUTOPHAGY Mitochondrial damage 
Rhabdomyolysis-induced acute kidney injury after administration of a red yeast rice supplement:A case report
《World Journal of Clinical Cases》2023年第23期5547-5553,共7页Ya-Han Wang Si-Shuo Zhang Hai-Tao Li Hong-Wei Zhi Hong-Yun Wu 
Supported by the Natural Science Foundation of Shandong Province,No.ZR2021QH110.
BACKGROUND A few reports have revealed induction of rhabdomyolysis by a red yeast rice(RYR)supplement or by RYR in combination with abiraterone(an androgen biosynthesis inhibitor).CASE SUMMARY A 76-year-old man presen...
关键词：RHABDOMYOLYSIS Acute kidney injury LOVASTATIN ABIRATERONE Case report 
AGR2-induced cholesterol synthesis drives lovastatin resistance that is overcome by combination therapy with allicin被引量：1
《Acta Pharmacologica Sinica》2022年第11期2905-2916,共12页Nan Sheng Yun-qiu Wang Cun-fu Wang Meng-qi Jia Huan-min Niu Qi-qi Lu Ya-nan Wang Dan Feng Xiao-xue Zheng Hui-qing Yuan 
the National Natural Science Foundation of China(81872896,82173839 and 32000891);Natural Science Foundation of Shandong Province(ZR2020QH363).
Anterior gradient 2(AGR2),a protein disulfide isomerase(PDI),is a multifunctional protein under physiological and pathological conditions.In this study we investigated the roles of AGR2 in regulating cholesterol bioge...
关键词：HYPERCHOLESTEROLEMIA cholesterol biogenesis AGR2 AKT/SREBP2 statin resistance ALLICIN 
Optimize the combination regimen of Trastuzumab and Nab-paclitaxel in HER2-positive tumors via modulating Caveolin-1 expression by lovastatin被引量：2
《Asian Journal of Pharmaceutical Sciences》2022年第5期697-712,共16页Canyu Yang Shumin Fan Xing Wang Wei Liu Long Yang Bing He Wenbing Dai Hua Zhang Xueqing Wang Qiang Zhang 
by the National Natural Science Foundation of China(Nos.81872809,82073786);the Beijing Natural Science Foundation(L212013).
The combination regimen of trastuzumab(Tras)plus Nab-paclitaxel(Nab)is recommended to treat HER2-positive(HER2+)cancers.However,they exert effects in different mechanisms:Tras need to stay on cell membranes,while Nab ...
关键词：CAVEOLIN-1 NAB-PACLITAXEL TRASTUZUMAB Combination regimen optimization 
Author Correction:Autophagy inhibitors increase the susceptibility of KRAS-mutant human colorectal cancer cells to a combined treatment of 2-deoxy-D-glucose and lovastatin
《Acta Pharmacologica Sinica》2022年第7期1881-1881,共1页Xiao-ming Huang Jia-jun Huang Jing-jing Du Na Zhang Ze Long You Yang Fang-fang Zhong Bo-wen Zheng Yun-fu Shen Zhe Huang Xiang Qin Jun-he Chen Qian-yu Lin Wan-jun Lin Wen-zhe Ma 
The authors apologize that in Fig.5d,the western blotting bands of HCT116 cells treated with 2DG(5 mM)and different concentrations of lovastatin were the same as cells treated with lovastatin(10μM)and different conce...
关键词：HCT116 LOVASTATIN KRAS 
Improvement of quality of Ginkgo biloba seeds powder by solid-state fermentation with Eurotium cristatum for developing high-value ginkgo seeds products被引量：2
《Journal of Bioresources and Bioproducts》2022年第2期53-62,共10页Minmin Zou Jiarui Cao Wen Zhang Chao Tang Fuliang Cao Erzheng Su 
This work was supported by China Postdoctoral Science Foundation(No.2017T100373,No.2016M600417);National Key R&D Program of China(No.2017YFD0600701);Six Talent Peaks Project in Jiangsu Province(No.2015-JY-016);333 Project of Jiangsu Province(No.BRA2017458).
In this study,we investigated the feasibility of Ginkgo biloba seeds powder by solid-state fermen-tation with Eurotium cristatum for developing high-value ginkgo seeds products.The optimum fermentation medium was cons...
关键词：Ginkgo seed Eurotium cristatum Solid-state fermentation LOVASTATIN Antioxidant activity Ginkgolic acid 
Effectiveness and safety of red yeast rice predominated by monacolin Kβ-hydroxy acid form for hyperlipidemia treatment and management被引量：1
《Journal of Traditional Chinese Medicine》2022年第2期264-271,共8页CHEN Benjian HUANG Xiaodan PENG Huiting LI Yishi CAO Yongtao WU Huanlin XU Danping 
Supported by Guangzhou Science and Technology Plan project(No.201710010107);Joint Innovation Specific Project in Key areas from Guangdong Branch Institute of China Academy of Chinese Medical Sciences(No.ZZ0908065);Project of Administration of Traditional Chinese Medicine of Guangdong Province of China(No.201811389)。
OBJECTIVE:To assess the lipid-lowering activity and safety of a dietary supplement containing monacolin Kβ-hydroxy acid form(MKA),Heye(Folium Nelumbinis),and Cangzhu(Rhizoma Atractylodis Lanceae),compared to lifestyl...
关键词：hydroxy acids LOVASTATIN HYPERLIPIDEMIAS CHOLESTEROL cardiovascular prevention lifestyle modifications red yeast rice 
Lovastatin as a supplement to mitigate rumen methanogenesis:an overview
《Journal of Animal Science and Biotechnology》2022年第2期353-364,共12页Amaury Ábrego-Gacía Héctor M.Poggi-Varaldo Vania Robles-González Teresa Ponce-Noyola Graciano Calva-Calva Elvira Ríos-Leal Daniel Estrada-Bárcenas Alfredo Mendoza-Vargas 
This research was funded by Basic Science Project SEP-CONACYT(grant number A1-S-26901);Partial funding from a personal grant of Dr.Héctor M.Poggi-Varaldo to the Environmental Biotechnology and Renewable Energies through CINVESTAV is appreciated.
Methane from enteric fermentation is the gas with the greatest environmental impact emitted by ruminants.Lovastatin(Lv)addition to feedstocks could be a strategy to mitigate rumen methane emissions via decreasing the ...
关键词：FERMENTATION LOVASTATIN METHANOGENESIS MICROBIOTA RUMEN 
Autophagy inhibitors increase the susceptibility of KRAS-mutant human colorectal cancer cells to a combined treatment of 2-deoxy-D-glucose and lovastatin被引量：2
《Acta Pharmacologica Sinica》2021年第11期1875-1887,共13页Xiao-ming Huang Jia-jun Huang Jing-jing Du Na Zhang Ze Long You Yang Fang-fang Zhong Bo-wen Zheng Yun-fu Shen Zhe Huang Xiang Qin Jun-he Chen Qian-yu Lin Wan-jun Lin Wen-zhe Ma 
funded by the Science and Technology Development Fund,Macao SAR,China(File no.0036/2020/A1,0013/2019/A1 and 0039/2020/A).
RAS-driven colorectal cancer relies on glucose metabolism to support uncontrolled growth.However,monotherapy with glycolysis inhibitors like 2-deoxy-D-glucose causes limited effectiveness.Recent studies suggest that a...
关键词：human colorectal cancers LOVASTATIN 2DG glycolysis OXPHOS AUTOPHAGY CHLOROQUINE HYDROXYCHLOROQUINE 
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