Effectiveness and safety of red yeast rice predominated by monacolin Kβ-hydroxy acid form for hyperlipidemia treatment and management  

作　　者：CHEN Benjian HUANG Xiaodan PENG Huiting LI Yishi CAO Yongtao WU Huanlin XU Danping 

机构地区：[1]Department of Medical,Guangdong Provincial Hospital of Chinese Medicine,The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510120,China [2]the Second Clinical College,Guangzhou University of Chinese Medicine,Guangzhou 510405,China [3]the First Clinical College,Guangzhou University of Chinese Medicine,Guangzhou 510405,China [4]Department of Mathematical&Computer Sciences,Indiana University of Pennsylvania,Indiana 15705,PA,USA [5]Department of Cardiology,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 350122,China [6]Department of Traditional Chinese Medicine,the Eighth Affiliated Hospital,SunYat-Sen University,Shenzhen 518033,China

出　　处：《Journal of Traditional Chinese Medicine》2022年第2期264-271,共8页中医杂志（英文版）

基　　金：Supported by Guangzhou Science and Technology Plan project(No.201710010107);Joint Innovation Specific Project in Key areas from Guangdong Branch Institute of China Academy of Chinese Medical Sciences(No.ZZ0908065);Project of Administration of Traditional Chinese Medicine of Guangdong Province of China(No.201811389)。

摘　　要：OBJECTIVE:To assess the lipid-lowering activity and safety of a dietary supplement containing monacolin Kβ-hydroxy acid form(MKA),Heye(Folium Nelumbinis),and Cangzhu(Rhizoma Atractylodis Lanceae),compared to lifestyle modifications.METHODS:Totally 117 subjects with moderate to severe dyslipidemia(according to Chinese guidelines)and low CV risk were randomly assigned into three treatment groups:lifestyle modification(LM),LM plus a low dosage of MKA,LM plus a high dosage of MKA,and treated for 60 d.The primary endpoint was the reduction of low density lipoprotein cholesterol(LDL-C)and total cholesterol(TC).Safeties along with Traditional Chinese Medicine Syndromes were assessed through the study.RESULTS:A low dosage of MKA along with lifestyle modifications caused a significant decrease in LDL-C by 15.6%on average(95%CI,9.6%to 21%)with,a decrease in TC by 15.3%on average(95%CI,9.26%to 21.4%),and a decrease in non-HDL-C by 35.4%(95%CI,25.76%to 41.34%).Weak evidence of a reduction of triglycerides but an increment of HDL-C was observed in patients with severe hyperlipidemia.No severe adverse events occurred during the study.CONCLUSION:Our results confirm the LDL-C and TC lowering properties of MKA is clinically meaningful.It also produces a significant reduction of non-HDL-C,and slightly effects on TG and HDL-C as well.

关 键 词：hydroxy acids LOVASTATIN HYPERLIPIDEMIAS CHOLESTEROL cardiovascular prevention lifestyle modifications red yeast rice 

分 类 号：R589.2[医药卫生—内分泌]