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作品数:1131被引量:2112H指数:18
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相关领域:医药卫生更多>>
相关作者:张杰李进王文华谢勇陈样新更多>>
相关机构:清华大学中国医学科学院北京协和医学院华中科技大学厦门大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国博士后科学基金更多>>
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Comment on“Development of an accelerometer age-and sex-specific approach based on population-standardized values for physical activity surveillance:A proof of concept”
《Journal of Sport and Health Science》2025年第2期79-81,共3页Alex V.Rowlands Richard P.Troiano 
Device-based measurements are recommended to improve population-based physical activity(PA)surveillance.1,2However,implementation remains challenging due to lack of consensus on analytical methods,and the most widely ...
关键词:ACCELEROMETER cut point approach physical activity age specific population standardized analytical methodsand analytical methods sex specific 
ABHD5 regulates midgut-specific lipid homeostasis in Bombyx mori
《Insect Science》2025年第2期425-436,共12页Zhiping Xing Yuting Zhang Hongxia Kang Hui Dong Dalin Zhu Yutong Liu Chenxin Sun Peilin Guo Bo Hu Anjiang Tan 
supported by the National Science Foundation of China(31925007 and 32000333);the Natural Science Foundation of Jiangsu Province(BK20221292).
Lipids are an important energy source and are utilized as substrates for various physiological processes in insects.Comparative gene identification 58(CGI-58),also known asα/βhydrolase domain-containing 5(ABHD5),is ...
关键词:ABHD5 Bombyx mori CRISPR/Cas9 lipid metabolism 
Mixed lineage kinase domain-like protein in liver diseases:Cell-typespecific functions and dual roles
《World Journal of Gastroenterology》2025年第14期161-167,共7页Ming-Xing Liang Ying Zhou Su-Qun Li Wan-Sheng Xiang Zong-Qin Pan Ying-Hua Chen Yi-Huai He 
Supported by the Science and Technology Planning Projects of Guizhou Province,No.QKHJC-ZK[2022]YB642;Health Research Project of Guizhou Province,No.gzwkj2024-324,and No.gzwkj2024-103;WBE Liver Fibrosis Foundation,No.CFHPC2025028;Beijing Liver and Gallbladder Mutual Aid Public Welfare Foundation Artificial Liver Special Fund,No.iGandanF-1082024-Rgg018;Student Innovation and Entrepreneurship Training Program of Zunyi Medical University,No.S2024106612360.
In this letter,we comment on the article by Xuan Yuan et al,published in the recent issue of the World Journal of Gastroenterology.Mixed lineage kinase domainlike protein(MLKL)exhibits cell-type-specific functions in ...
关键词:Cell-type-specific functions Dual roles Liver diseases Mixed lineage kinase domain-like protein NECROPTOSIS 
Uncovering the Pre-Deterioration State during Disease Progression Based on Sample-Specific Causality Network Entropy(SCNE)
《Research》2025年第1期55-67,共13页Jiayuan Zhong Hui Tang Ziyi Huang Hua Chai Fei Ling Pei Chen Rui Liu 
supported by National Natural Science Foundation of China(nos.T2341022,12322119,62172164,and 12271180);Guangdong Provincial Key Laboratory of Human Digital Twin(2022B1212010004);Educational Commission of Guangdong Province of China(2023KQNCX073);the Natural Science Foundation of Guangdong Province of China(2022A-1515110759,and 2023A1515110558);Fundamental Research Funds for the Central Universities(2023ZYGXZR077).
Complex diseases do not always follow gradual progressions.Instead,they may experience sudden shifts known as critical states or tipping points,where a marked qualitative change occurs.Detecting such a pivotal transit...
关键词:critical states sample specific causality network entropy pre deterioration state complex diseases tipping points high dimensional data numerical simulations 
Identification of chikusetsusaponin IVa as a novel lysine-specific demethylase 1 inhibitor that ameliorates high fat diet-induced MASLD in mice
《Acta Pharmacologica Sinica》2025年第3期632-652,共21页Yu-wen Liu Ru-yue Luo An-qi Liu Jia-wei Wang Na-ping Hu Wang-ting Li Jian-kang Li Jing-wen Wang Jia-lin Duan 
supported by the National Natural Science Foundation of China(81903832);Key Research and Development Plan of Shaanxi Province(2022SF-182);Fundamental Research Funds for the Central Universities(D5000210799);Shaanxi Provincial Traditional Chinese Medicine Administration“Double Chain Integration”Middle Youth Research and Innovation Team Project(2022-SLRH-LJ-007);Shanghai Science and Technology Innovation Action Plan(22S21902600).
Diet-induced metabolic dysfunction steatotic liver disease(MASLD)is also called as non-alcoholic fatty liver disease(NAFLD)with limited effective strategies available.We previously have shown that chikusetsusaponin IV...
关键词:MASLD chikusetsusaponin Iva LSD1 fatty acid oxidation FXR/SHP CREBH 
Partial multi-label learning via label-specific feature corrections
《Science China(Information Sciences)》2025年第3期91-105,共15页Jun-Yi HANG Min-Ling ZHANG 
supported by National Natural Science Foundation of China(Grant No.62225602);Big Data Computing Center of Southeast University。
Partial multi-label learning(PML)allows learning from rich-semantic objects with inaccurate annotations,where a set of candidate labels are assigned to each training example but only some of them are valid.Existing ap...
关键词:machine learning multi-label learning partial multi-label learning label-specific features feature correction 
A universal approach for extraction of single-walled carbon nanotubes of specific chirality using aqueous two-phase extraction
《Nano Research》2025年第2期806-816,共11页Blazej Podlesny Lukasz Czapura Patrycja Taborowska Luyao Zhang Feng Yang Dawid Janas 
The development of effective methods for obtainingmonochiral single-walledcarbonnanotubes(SWCNTs)is necessary to make many applications based on them viable for everyday use.Large-diameter semiconducting SWCNTs are pa...
关键词:single-walled carbon nanotubes PURIFICATION FUNCTIONALIZATION sensing 
Versatile chiroptical induction/manipulation through specific solvation of ion pairs by alcohols
《Science China Chemistry》2025年第2期610-621,共12页Chunhong Liu Xin Chen Yanling Shen Ting Zhao Dayang Zhou Kun Li Jiecheng Ji Wanhua Wu Xuemei Pu Cheng Yang 
supported by the National Natural Science Foundation of China(22471182,22271201,92056116,22422108,22171194,22201194);the Fundamental Research Funds for the Central Universities(20826041D4117).
While extensive research has explored manipulating supramolecular chirality through internal and external factors,the specific solvation effect remains uncharted territory.This study synthesized ortho-functionalized p...
关键词:chiroptical induction specific solvation ion pair arene H-BOND 
Specific Position and Influence of Moisture in Newly-Installed Composite Insulators
《CSEE Journal of Power and Energy Systems》2025年第1期440-446,共7页Sida Zhang Li Cheng Ruijin Liao Yunfan Liu 
supported in part by the National Natural Science Foundation of China(No.52077013);Science and Technology Project of Electric Power Research Institute of China Southern Power Grid Co.(No.066600KK52190015 and 1500002020030101JC00074).
Abnormal heating of composite insulators is a hidden threat to safe operation of transmission lines.Although moisture is considered the key factor leading to temperature rise in high humidity areas,specific position a...
关键词:Composite insulation dielectric heating failure analysis inference mechanisms 
Intranasal iron administration induces iron deposition,immunoactivation,and cell-specific vulnerability in the olfactory bulb of C57BL/6 mice
《Zoological Research》2025年第1期209-224,共16页Xiao-Qing Mi Bao-Chen Liu Le Qu Yu Yuan Hui Li Ao-Yang Xu Yu-Lin Zhang Jun-Xia Xie Ning Song 
supported by the National Natural Science Foundation of China (32471188,32170984,82301787)。
Iron is the most abundant transition metal in the brain and is essential for brain development and neuronal function;however,its abnormal accumulation is also implicated in various neurological disorders.The olfactory...
关键词:Intranasal administration Olfactory bulb IRON Ferroptosis Immune response 
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