PYRUVATE

作品数：70被引量：147H指数：8
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相关领域：医药卫生生物学更多>>
相关作者：马海田陈娟王曼孔一力迟伟更多>>
相关机构：南京农业大学江苏省农业科学院中国预防医学科学院中山大学更多>>
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相关基金：国家自然科学基金北京市自然科学基金国家教育部博士点基金国家重点基础研究发展计划更多>>
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Current knowledge about pyruvate supplementation:A brief review被引量：1
《Sports Medicine and Health Science》2024年第4期295-301,共7页Robert A.Olek Sylwester Kujach Zsolt Radak 
Pyruvate is a three-carbon ketoacid that occurs naturally in cells.It is produced through enzymatic reactions in the glycolytic pathway and plays a crucial role in energy metabolism.Despite promising early results,lat...
关键词：ACIDOSIS BICARBONATE LACTATE Nicotinamide adenine dinucleotide SIRTUINS 
Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice
《Protein & Cell》2024年第9期661-685,共25页Sadaf Hasan Nabil Ghani Xiangli Zhao Julia Good Amanda Huang Hailey Lynn Wrona Jody Liu Chuan-ju Liu 
supported by National Institutes of Health(NIH)research grants R01AR062207,R01AR061484,R01AR076900,R01AR078035 and R01NS070328.
Obesity has a multifactorial etiology and is known to be a state of chronic low-grade inflammation,known as meta-inflammation.This state is associated with the development of metabolic disorders such as glucose intole...
关键词：metabolic disease PYRUVATE cytosolic phospholipase OBESITY 
Antibody switch AIDed by pyruvate
《Life Metabolism》2024年第2期1-2,共2页Haoming Luan Tiffany Horng 
Metabolism is mobilized to meet the biosynthetic,bioenergetic,and regulatory demands of immune cell activation.Almost nothing is known about the metabolic basis of antibody class switch in B cells.A recent study publi...
关键词：functions. ACTIVATION ALMOST 
Biotransformation of 2-keto-4-hydroxybutyrate via aldol condensation using an efficient and thermostable carboligase from Deinococcus radiodurans
《Bioresources and Bioprocessing》2024年第1期111-123,共13页Yeon-Ju Jeong Min-Ju Seo Bong Hyun Sung Jeong-Sun Kim Soo-Jin Yeom 
supported by Grants from the C1 Gas Refinery Program,funded by the Ministry of Science and ICT(NRF-2018M3D3A1A01056181);the Enzyme engineering for next generation biorefinery(NRF-2022M3J5A1056169 and NRF-2022M3J5A1085239)from National Research Foundation(NRF);the Korea Research Institute of Bioscience and the Biotechnology(KRIBB)Research Initiative Program.
The bioconversion of 4-hydroxy-2-keto acid derivatives via aldol condensation of formaldehyde and pyruvate has received substantial attention as potential source of chemicals for production of amino acids,hydroxy carb...
关键词：Formaldehyde PYRUVATE Pyruvate aldolase 2-keto-4-hydroxybutyrate Deinococcus radiodurans 
Mitochondrial YBX1 promotes cancer cell metastasis by inhibiting pyruvate uptake
《Life Metabolism》2023年第6期28-41,共14页Huan Chen Ting Ling Di Chen Wenjuan Liu Huan Qi Tian Xia Xiaolong Liu Wen Wang Xin Guo Wuxiyar Otkur Fangjun Wang Zhaochao Xu Jean-Claude Martinou Hai-long Piao 
This study was supported by the National Key Research and Development Program of China(2022YFA0806503);grants from the National Natural Science Foundation of China(No.81972625,No.21907093);Dalian Science and Technology Innovation Funding(2019J12SN52);Liaoning Revitalization Talents Program(XLYC2002035).
Pyruvate is an essential fuel for maintaining the tricarboxylic acid(TCA)cycle in the mitochondria.However,the precise mole-cular mechanism of pyruvate uptake by mitochondrial pyruvate carrier(MPC)is largely unknown.H...
关键词：MITOCHONDRIA YBX1 pyruvate metabolism MPC1/2 METASTASIS 
QM/MM study on the O_(2)activation reaction of 4-hydroxylphenyl pyruvate dioxygenase reveals a common mechanism forα-ketoglutarate dependent dioxygenase
《Chinese Chemical Letters》2023年第5期461-465,共5页Linhui Li Suitian Lai Hongyan Lin Xinyun Zhao Xin Li Xi Chen Junjun Liu Guangfu Yang Changguo Zhan 
supported by the National Key R&D Program(No.2021YFD1700100);National Natural Science Foundation of China(Nos.21837001,21273089);the Open Project Fund of the Key Laboratory of the Pesticides and Chemical Biology of Central China Normal University(No.2018-A01);the Fundamental Research Funds for the Central Universities;the Fundamental Research Funds for the South-Central University for Nationalities(No.CZW20020)。
The dioxygen activation catalyzed by 4-hydorxylphenyl pyruvate dioxygenase(HPPD)were reinvestigated by using hybrid quantum mechanics/molecular mechanics(QM/MM)approaches at the B3LYP/6-311++G(d,p):AMBER level.These s...
关键词：4-Hydroxylphenyl pyruvate dioxygenase O_(2)activation QM/MM Mechanism Minimum energy crossing point 
Efficient acetoin production from pyruvate by engineered Halomonas bluephagenesis whole-cell biocatalysis被引量：1
《Frontiers of Chemical Science and Engineering》2023年第4期425-436,共12页Meiyu Zheng Zhenzhen Cui Jing Zhang Jing Fu Zhiwen Wang Tao Chen 
supported by the National Key Research and Development Program of China (Grant No.2018YFA0900200);the National Natural Science Foundation of China (Grant No.NSFC-21621004).
Acetoin is an important platform chemical,which has a wide range of applications in many industries.Halomonas bluephagenesis,a chassis for next generation of industrial biotechnology,has advantages of fast growth and ...
关键词：ACETOIN PYRUVATE α-acetolactate synthetase α-acetolactate decarboxylase Halomonas bluephagenesis whole-cell biocatalysis 
Glycolytic potential enhanced by blockade of pyruvate influx into mitochondria sensitizes prostate cancer to detection and radiotherapy被引量：2
《Cancer Biology & Medicine》2022年第9期1315-1333,共19页Huan Xu Junyi Chen Zhi Cao Xi Chen Caihong Huang Jin Ji Yalong Xu Junfeng Jiang Yue Wang Guowang Xu Lina Zhou Jingyi He Xuedong Wei Jason Boyang Wu Zhong Wang Shancheng Ren Fubo Wang 
supported by the National Natural Science Foundation of China(NSFC)(Grant No.81902616 to F.W.);Science and Technology Support Project in the field of biomedicine of Shanghai Science and Technology Action Plan(Grant No.19441909200,F.W.);Clinical Research Project of Shanghai Municipal Commission of Health and Family Planning(Grant No.20184Y0130,F.W.);Precision Medicine Program of Second Military Medical University(Grant No.2017JZ35,F.W.);Youth Startup Program of the Second Military Medical University(Grant No.2016QN12,F.W.);Jiangsu Provincial Medical Youth Talent(Grant No.QNRC2016739,X.W.);Shanghai Sailing Program(Grant No.21YF1423300,H.X.);Natural Science Foundation of Shanghai(Grant No.21ZR1437800,H.X.);Cross-disciplinary Research Fund of Shanghai Ninth People’s Hospital,Shanghai Jiaotong University School of Medicine(Grant No.YG2021QN75,H.X.).
Objective:This study aimed to evaluate the effects of mitochondrial pyruvate carrier(MPC)blockade on the sensitivity of detection and radiotherapy of prostate cancer(PCa).Methods:We investigated glycolysis reprogrammi...
关键词：Glycolytic potential prostate cancer mitochondrial pyruvate carrier(MPC) mitochondria pyruvate influx diagnosis RADIOTHERAPY 
Mitochondria1l pyruvate carrier:a metabolic-epigenetic checkpoint orchestrating T cell differentiation
《Signal Transduction and Targeted Therapy》2022年第9期3163-3165,共3页Yu Chen Jingchun Wang Yongsheng 
This work was supported by the Major International(Regional)Joint Research Programof theNationalNatural ScienceFoundationof China(No.81920108027);ChongqingOutstandingYouth ScienceFoundation(No.cstc2020jcyj-jqx0030);Chongqing Talent Innovation Leader Project(No.CQYC20200301111);Funding for Chongqing University Innovation Research Group.
In a recent study published in Cell Metabolism,Wenes et al.1identifed that the inhibition of mitochondrial pyruvate carrier(MPC)led to CD8^(+) memory T cell(T_(mem))differentiation and facilitated superior and long-la...
关键词：TUMOR lasting 
Pyruvate enhances M1 microglial polarization via the NF-κB/MCT1/iNOS signaling axis under low-glucose conditions被引量：1
《解剖学杂志》2021年第S01期40-41,共2页Zhou Peng Du Juanjuan Zhou Tao Sun Chenyou Cui Huairui Ding Maochao Yang Chaorian Liao Min 
Proinflammatory microglia rely predominantly on glycolysis to maintain cytokine production during ischemia,accompanied with the increases of inducible nitric oxide synthase(iNOS)and monocarboxylate transporter 1(MCT1)...
关键词：ISCHEMIA CYTOKINE INOS CT1 
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