Pyruvate is a three-carbon ketoacid that occurs naturally in cells.It is produced through enzymatic reactions in the glycolytic pathway and plays a crucial role in energy metabolism.Despite promising early results,lat...
This research was supported by Tsinghua University Initiative Scientific Research Program (to M.P.) and funds from Tsinghua-Peking Center for Life Sciences and Institute forImmunology at Tsinghua University (to M.P.).
The symbiotic relationship between the host and microbiota is widely acknowledged as mutually beneficial.However,due to significant differences in metabolic substrates and products between prokaryotic bacteria and mam...
The purpose of this manuscript was to present the evidence for why cells do not produce metabolic acids.In addition,evidence that opposes common viewpoints and arguments used to support the cellular production of lact...
Diabetic ketoacidosis (DKA) can cause significant morbidity and mortality in patient with both type 1 and type 2 diabetes mellitus. A subset of DKA cases termed euglycemic diabetic ketoacidosis (EDKA) is characterized...
The purpose of this review and commentary was to provide an historical and evidence-based account of organic acids and the biochemical and organic chemistry evidence for why cells do not produce metabolites that are a...
BACKGROUND Case reports of symmetric digital gangrene resulting from high-dose vasopressors use in patients with alcoholic ketoacidosis,leading to cardiac arrest,are rare.To date,no specific treatment method for autol...
Diabetes has been classified mainly into types 1 and 2.Some type 2 diabetes patients,when developing ketosis,have been labeled as having atypical diabetes.Lately,syndromes of ketosis-prone diabetes,primarily in patien...
BACKGROUND Insulin pump therapy is a real breakthrough in managing diabetes Mellitus,particularly in children. It can deliver a tiny amount of insulin and decreases the need for frequent needle injections. It also hel...
supported by grants awarded to KeWei Wang from National Natural Science Foundation of China (81903734 and81973299);the Ministry of Science and Technology of China(2018ZX09711001-004-006)。
Ischemic brain stroke is pathologically characterized by tissue acidosis, sustained calcium entry and progressive cell death. Previous studies focusing on antagonizing N-methyl-D-aspartate(NMDA) receptors have failed ...
supported by the National Natural Science Foundation of China (No. 81973261);the Foundation of West China Hospital of Stomatology (No. RD-02–201903);the Research Funding from West China School/Hospital of Stomatology, Sichuan University (No. RCDWJS2020–7)。
Cancer is a serious threat to humans due to its high mortality. The efforts to fully understand cancer and to fight against it have never been stopped. The traditional therapies, such as surgery, radiotherapy and chem...