Pyruvate enhances M1 microglial polarization via the NF-κB/MCT1/iNOS signaling axis under low-glucose conditions  

作　　者：Zhou Peng Du Juanjuan Zhou Tao Sun Chenyou Cui Huairui Ding Maochao Yang Chaorian Liao Min 

机构地区：[1]Department of Anatomy,Basic Medical College of Wenzhou Medical University,Wenzhou 325035

出　　处：《解剖学杂志》2021年第S01期40-41,共2页Chinese Journal of Anatomy

摘　　要：Proinflammatory microglia rely predominantly on glycolysis to maintain cytokine production during ischemia,accompanied with the increases of inducible nitric oxide synthase(iNOS)and monocarboxylate transporter 1(MCT1).Whether there is a link between iNOS and MCT1 expression patterns and pyruvate could act as an energy source to sustain the M1 proinflammatory microglial phenotype,however,remain unclear.In the present study,we examined responses from microglia in the mouse brains subjected to ischemia,and treated with low glucose treatment in vitro.

关 键 词：ISCHEMIA CYTOKINE INOS CT1 

分 类 号：R73[医药卫生—肿瘤]