CILOSTAZOL

作品数：25被引量：63H指数：5
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相关领域：医药卫生更多>>
相关作者：刘占军徐耕刘杨东时德廖晓刚更多>>
相关机构：重庆医科大学浙江大学医学院附属第二医院重庆医科大学附属第一医院广州医学院第二附属医院更多>>
相关期刊：《Chinese Medical Journal》《中华物理医学与康复杂志》《国际脑血管病杂志》《精细与专用化学品》更多>>
相关基金：泰国研究基金更多>>
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Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING:the inhibitory effect of Cilostazol
《Acta Pharmacologica Sinica》2024年第9期1879-1897,共19页Zhi-hua Zheng Jiao-jiao Wang Jiu-guo Lin Wei-le Ye Jia-mi Zou Li-yin Liang Ping-lian Yang Wan-lu Qiu Yuan-yuan Li Si-jia Yang Man Zhao Qing Zhou Cheng-zhi Li Min Li Zhuo-ming Li Dong-mei Zhang Pei-qing Liu Zhi-ping Liu 
National Natural Science Foundation of China(82270500,81870324,82203304,U21A20419);Guangdong Basic and Applied Basic Research Foundation(2024B1515020113);Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y093);National Engineering and Technology Research Center for New Drug Druggability Evaluation(Seed Program of Guangdong Province,2017B090903004).
Endothelial senescence,aging-related inflammation,and mitochondrial dysfunction are prominent features of vascular aging and contribute to the development of aging-associated vascular disease.Accumulating evidence ind...
关键词：CILOSTAZOL STING endothelial cell senescence INFLAMMATION mitochondrial dysfunction atherosclerosis 
Cilostazol and isosorbide mononitrate for the prevention of progression of cerebral small vessel disease:baseline data and statistical analysis plan for the Lacunar Intervention Trial-2(LACI-2)(ISRCTN14911850)被引量：3
《Stroke & Vascular Neurology》2023年第2期134-143,共10页Philip M Bath Iris Mhlanga Lisa J Woodhouse Fergus Doubal Katherine Oatey Alan A Montgomery Joanna M Wardlaw LACI-Trial Investigators 
support for the research,authorship,and/or publication of this article:This work is supported by British Heart Foundation(CS/15/5/31475);the Alzheimer’s Society(AS-PG 14-033);EU Horizon 2020 SVDs@Target(666881);MRC UK DRI,Fondation Leducq(16/05 CVD);NHS Research Scotland,The Stroke Association and Garfield-Weston Foundation,Chief Scientist Office(UC);National Institute of Health Research.PMB is Stroke Association Professor of Stroke Medicine and an Emeritus NIHR Senior Investigator.
Background Cerebral small vessel disease(SVD)causes lacunar strokes(25%of all ischaemic strokes),physical frailty and cognitive impairment and vascular and mixed dementia.There is no specific treatment to prevent prog...
关键词：NITRATE initiated PREVENTION 
Correction:Cilostazol and isosorbide mononitrate for the prevention of progression of:baseline data and statistical analysis plan for the Lacunar Intervention Trial-2(LACI-2)(ISRCTN14911850)
《Stroke & Vascular Neurology》2023年第2期I0001-I0001,共1页
Bath PM,Mhlanga I,Woodhouse LJ,et al.Cilostazol and isosorbide mononitrate for the prevention of progression of:baseline data and statistical analysis plan for the Lacunar Intervention Trial-2(LACI-2)(ISRCTN14911850)....
关键词：nitrate DETAILS PREVENTION 
Cilostazol for secondary stroke prevention:systematic review and meta-analysis被引量：3
《Stroke & Vascular Neurology》2021年第3期410-423,I0035-I0053,共33页Choon Han Tan Andrew GR Wu Ching-Hui Sia Aloysius ST Leow Bernard PL Chan Vijay Kumar Sharma Leonard LL Yeo Benjamin YQ Tan 
Background Stroke is one of the leading causes of death worldwide.Cilostazol,an antiplatelet and phosphodiesterase 3 inhibitor,has not been clearly established for ischaemic stroke use.We aim to determine the efficacy...
关键词：PREVENTION CILOSTAZOL REGIMEN 
The efficacy and safety of cilostazol as an alternative to aspirin in Chinese patients with aspirin intolerance after coronary stent implantation： a combined clinical study and computational system pharmacology analysis被引量：8
《Acta Pharmacologica Sinica》2018年第2期205-212,共8页Ying XUE Zhi-wei FENG Xiao-ye LI Zi-heng HU Qing XU Zi WANG Jia-hui CHENG Hong-tao SHI Qi-bing WANG Hong-yi WU Xiang-Qun XIE Qian-zhou LV 
Dual antiplatelet therapy （DAT） with aspirin and clopidogrel is the standard regimen to achieve rapid platelet inhibition and prevent thrombotic events. Currently, little information is available regarding alternati...
关键词：dual antiplatelet therapy ASPIRIN INTOLERANCE citostazol percutaneous coronary intervention major adverse cardiac events network system pharmacology 
Cilostazol for Aizheimer＇s disease
《中华物理医学与康复杂志》2017年第4期263-263,共1页
关键词：阿尔茨海默病 乙酰胆碱酯酶抑制剂 治疗 磷酸二酯酶 抗细胞凋亡 西洛他唑 抗氧化 大脑 
Cilostazol inhibits plasmacytoid dendritic cell activation and antigen presentation被引量：1
《Journal of Geriatric Cardiology》2015年第4期388-393,共6页Fei SUN Zhao YIN Hai-Sheng YU Quan-Xing SHI Bei ZHAO Li-Guo ZHANG Shou-Li WANG 
Background Cilostazol, an anti-platelet drug for treating coronary heart disease, has been reported to modulate immune cell functions Plasmacytoid dendritic cells （pDCs） have been found to participate in the progres...
关键词：Antigen presentation CILOSTAZOL Interferon α Plasmacytoid dendritic cell Tumor necrosis factor α 
Effects of cilostazol on the progression and regression of symptomatic intracranial artery stenosis:it reduces the risk of ischemic stroke被引量：2
《Neural Regeneration Research》2015年第4期667-672,共6页Wen-hui Zhang Fang-fang Cai Zhong-min Wen 
OBJeCTIve：To assess the efifcacy and safety of cilostazol on the progression and regression of symptomatic intracranial artery stenosis. DATA ReTRIvAL： We searched the main databases for eligible trials including Me...
关键词：nerve regeneration systemic review CILOSTAZOL ATHEROSCLEROSIS ASPIRIN stroke ischemic magnetic resonance angiography transcranial Doppler intracranial artery stenosis follow-up studies neural regeneration 
Determination of cilostazol and its active metabolite 3,4-dehydro cilostazol from small plasma volume by UPLC-MS/MS被引量：2
《Journal of Pharmaceutical Analysis》2015年第1期1-11,共11页Nejal M.Bhatt Vijay D.Chavada Daxesh P.Patel Primal Sharma Mallika Sanyal Pranav S.Shrivastav 
A simple,rapid and sensitive ultra performance liquid chromatography-tandem mass spectrometry（UPLC-MS/MS） method has been developed for the simultaneous determination of cilostazol and its pharmacologically active m...
关键词：Cilostazol 3 4-dehydro cilostazol UPLC-MS/MS Sensitive High throughput 
Phosphodiesterase-3 inhibitor （cilostazol） attenuates oxidative stress-induced mitochondrial dysfunction in the heart被引量：3
《Journal of Geriatric Cardiology》2014年第2期151-157,共7页Siriporn C. Chattipakom Savitree Thummasorn Jantira Sanit Nipon Chattipakorn 
Background Cilostazol is a type 3 phosphodiesterase inhibitor which has been previously demonstrated to prevent the occurrence of tachyarrhythmia and improve defibrillation efficacy. However, the mechanism for this be...
关键词：Phosphodiesterase-3 inhibitor CILOSTAZOL Mitochondria HEART Oxidative stress Membrane potential ISCHEMIA 
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