Interactions Between Astrocytes and Oligodendroglia in Myelin Development and Related Brain Diseases  

作　　者：Xuelian Hu Guangdan Yu Xiang Liao Lan Xiao 

机构地区：[1]School of Medicine,Chongqing University,Chongqing 400030,China [2]Department of Histology and Embryology,Chongqing Key Laboratory of Neurobiology,Brain and Intelligence Research Key Laboratory of Chongqing Education Commission,Third Military Medical University,Chongqing 400038,China

出　　处：《Neuroscience Bulletin》2023年第3期541-552,共12页神经科学通报（英文版）

基　　金：supported by the Ministry of Science and Technology of China(2021ZD0201700);the National Natural Science Foundation of China(31921003).

摘　　要：Astrocytes(ASTs)and oligodendroglial lineage cells(OLGs)are major macroglial cells in the central nervous system.ASTs communicate with each other through connexin(Cx)and Cx-based network structures,both of which allow for quick transport of nutrients and signals.Moreover,ASTs interact with OLGs through connexin(Cx)-mediated networks to modulate various physiological processes in the brain.In this article,following a brief description of the infrastructural basis of the glial networks and exocrine factors by which ASTs and OLGs may crosstalk,we focus on recapitulating how the interactions between these two types of glial cells modulate myelination,and how the AST-OLG interactions are involved in protecting the integrity of the blood-brain barrier(BBB)and regulating synaptogenesis and neural activity.Recent studies further suggest that AST-OLG interactions are associated with myelin-related diseases,such as multiple sclerosis.A better understanding of the regulatory mechanisms underlying AST-OLG interactions may inspire the development of novel therapeutic strategies for related brain diseases.

关 键 词：ASTROCYTE OLIGODENDROGLIA Glial network MYELINATION SYNAPTOGENESIS Neuroinfammation 

分 类 号：R749.4[医药卫生—神经病学与精神病学]