Control of demyelination for recovery of spinal cord injury  

作　　者：吴波 任先军 

机构地区：[1]Department of Orthopedics, Xinqiao Hospital, ThirdMilitary Medical University, Chongqing 400037, China

出　　处：《Chinese Journal of Traumatology》2008年第5期306-310,共5页中华创伤杂志（英文版）

摘　　要：Since loss of oligodendrocytes and consequent demyelination of spared axons severely impair the functional recovery of injured spinal cord, it is reasonably expected that the reduction of oligodendroglial death and enhanced remyelination of demyelinated axons will have a therapeutic potential to treat spinal cord injury. Amelioration of axonal myelination in the injured spinal cord is valuable for recovery of the neural function of incompletely injured patients. Here, this article presents an overview about the patho-physiology and mechanism of axonal demyelination in spinal cord injury and discusses its therapeutic significance in the treatment of spinal cord injury. Moreover, it further introduces the recent strategies to improve the axonal myeliantion to facilitate functional recovery of spinal cord injury.

关 键 词：OLIGODENDROGLIA Cell transplantation Spinal cord injuries 

分 类 号：R651.2[医药卫生—外科学]