Ten ring-B aromatized ergosterols from Aspergillus spectabilis  

作　　者：WEI Mengsha SUN Weiguang LIU Linlin LI Yongqi LI Lanqin LI Qin CHEN Yu GUO Jieru GU Lianghu ZHU Hucheng CHEN Chunmei ZHANG Yonghui 

机构地区：[1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation,School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [2]Tongji Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

出　　处：《Chinese Journal of Natural Medicines》2024年第7期654-662,共9页中国天然药物（英文版）

基　　金：supported by the National Key Research and Development Program of China(No.2021YFA0910500);the National Natural Science Foundation of China(No.U22A20380 and 82104043);the Innovative Research Groups of the National Natural Science Foundation of China(No.81721005);the Science and Technology Major Project of Hubei Province(No.2021ACA012).

摘　　要：Spectasterols F−O(1−10),ten interesting ergosterols with an aromatized B ring,were obtained from Aspergillus spectabilis.Their structures and absolute configurations were determined using a combination of high-resolution electrospray ionization mass spectrometry(HR-ESI-MS),nuclear magnetic resonance(NMR)spectroscopy,single-crystal X-ray diffraction analyses,and electronic circular dichroism(ECD)calculations.Structurally,these aromatic ergosterols feature versatile side chains.Notably,compound aromatic ergosterols featured versatile side chains,and compound 4 is an unusual C23 ergosterol characterized by a shorter side chain due to oxidative cleavage between C-23 and C-24.All compounds were evaluated for their neuroprotective activities,with compound 8 showing a dose-dependent ability to reduce apoptosis and protect mitochondrial function in glutamate-induced SH-SY5Y cells.

关 键 词：STEROIDS Aspergillus spectabilis Aromatic ergosterols Neuroprotective activities Structure elucidation 

分 类 号：R284.1[医药卫生—中药学]