Effects of Dezocine and Propofol Combination on Plasma 5-HT and ET Levels in Stroke Patients Undergoing Thrombolysis  

作　　者：Fangfang Lv Xiuhong Wang Weibo Wang 

机构地区：[1]Anesthesiology Department,Linshu County People’s Hospital,Linyi 276000,Shandong Province,China [2]Laboratory Medicine Center,Linyi People’s Hospital,Linyi 276003,Shandong Province,China

出　　处：《Journal of Clinical and Nursing Research》2024年第9期234-239,共6页临床护理研究（英文）

摘　　要：Objective: To investigate the effect of dezocine combined with propofol on brain metabolism in patients undergoing cerebral thrombosis thrombolysis. Methods: A total of 86 stroke patients admitted between July 2022 and December 2023 were randomly divided into two groups: Group A (study group) and Group B (control group), with 43 patients in each group. Both groups underwent intra-arterial thrombolysis therapy. Group B received dezocine for anesthesia, while Group A received a combination of dezocine and propofol. Plasma concentrations of 5-hydroxytryptamine and endothelin, as well as brain metabolic indicators, were compared between the two groups immediately after anesthesia, at 1 hour post-reperfusion, and 3 hours post-reperfusion. Results: There were no significant differences in the levels of 5-hydroxytryptamine and endothelin between the two groups immediately after anesthesia and at 1 hour post-reperfusion (P > 0.05). However, at 3 hours post-reperfusion, the levels of 5-hydroxytryptamine and endothelin in Group A were significantly lower than those in Group B. Furthermore, in Group A, the levels of 5-hydroxytryptamine and endothelin at 3 hours post-reperfusion were lower compared to the levels at 1 hour post-reperfusion (P < 0.05). Conclusion: Dezocine combined with propofol can effectively improve the quality of anesthesia and has a minimal effect on brain metabolic indices, suggesting reduced damage to brain metabolism.

关 键 词：DEZOCINE PROPOFOL 5-HYDROXYTRYPTAMINE ENDOTHELIN Cerebral apoplexy 

分 类 号：R61[医药卫生—外科学]