PROPOFOL

作品数：333被引量：1288H指数：16
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相关领域：医药卫生更多>>
相关作者：于金贵岳云张国华郑晖郑志鸿更多>>
相关机构：山东大学首都医科大学附属北京朝阳医院北京大学兰州大学更多>>
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相关基金：国家自然科学基金湖北省自然科学基金北京市自然科学基金国家重点基础研究发展计划更多>>
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The occurrence of propofol injection pain in the emergency department:an exploratory analysis
《World Journal of Emergency Medicine》2025年第2期161-163,共3页Mischa Veen M.Christien van der Linden 
Propofol(2,6-di-isopropylphenol) is a short-acting,intravenous sedative drug.^([1,2]) The pharmacologic mechanism of propofol is related to its agonistic effects on the gamma-amino butyric acid receptor.^([1-3]) Propo...
关键词：INJECTION ANESTHESIA PAIN 
Accurate Machine Learning‑based Monitoring of Anesthesia Depth with EEG Recording
《Neuroscience Bulletin》2025年第3期449-460,共12页Zhiyi Tu Yuehan Zhang Xueyang Lv Yanyan Wang Tingting Zhang Juan Wang Xinren Yu Pei Chen Suocheng Pang Shengtian Li Xiongjie Yu Xuan Zhao 
supported by grants from the Shanghai Municipal Health Commission(2023ZDFC0203);the National Natural Science Foundation of China(32171044).
General anesthesia,pivotal for surgical procedures,requires precise depth monitoring to mitigate risks ranging from intraoperative awareness to postoperative cognitive impairments.Traditional assessment methods,relyin...
关键词：ELECTROENCEPHALOGRAM PROPOFOL KETAMINE Machine learning Anesthesia monitoring 
Effect of etomidate added to propofol target-controlled infusion in bidirectional endoscopy:A randomized clinical trial
《World Journal of Gastrointestinal Endoscopy》2025年第2期55-64,共10页Hui-Rong Luo An-Di Chen Jing-Fang Lin Peng Ye Ying-Jie Chen Ming-Xue Lin Pin-Zhong Chen Xiao-Hui Chen Xiao-Chun Zheng 
BACKGROUND Propofol has been widely used in bidirectional gastrointestinal endoscopy sedation;however,it frequently leads to cardiovascular adverse events and respiratory depression.Propofol target-controlled infusion...
关键词：PROPOFOL ETOMIDATE Target-controlled infusion Bidirectional endoscopy Adverse reactions 
Propofol-Induced Moderate-Deep Sedation Modulates Pediatric Neural Activity:A Functional Connectivity Study
《iRADIOLOGY》2025年第1期61-71,共11页Qiang Zheng Yiyu Zhang Lin Zhang Jian Wang Jungang Liu 
supported by the Natural Science Foundation of Shandong Province,ZR2024MH072;Open Project of Key Laboratory of Medical Imaging and Artificial Intelligence of Hunan Province,Xiangnan University,YXZN2022002;Projects of Xiamen Scientific and Technological Plan,3502Z20199096 and 3502Z20209220;the National Natural Science Foundation of China,61802330;the Yantai City Science and Technology Innovation Development Plan,2023XDRH006.
Background:Previous studies have demonstrated the underlying neurophysiologic mechanism during general anesthesia in adults.However,the mechanism of propofol-induced moderate-deep sedation(PMDS)in modulating pediatric...
关键词：functional connectivity network moderate-deep sedation neural activity PEDIATRIC PROPOFOL 
Clinical evaluation of bispectral index-guided closed-loop infusion of propofol for preschool children:A multi-center randomized controlled study
《Pediatric Investigation》2024年第4期271-277,共7页Lei Hua Bin Du Yunxia Zuo Huacheng Liu Jianmin Zhang 
Importance:The closed-loop infusion system can automatically adjust and maintain the depth of anesthesia by using the propofol target-controlled infusion(TCI)model under the feedback guidance of the bispectral index(B...
关键词：CLOSED-LOOP Target-controlled infusion Bispectral index Preschool children 
Propofol suppressed cell proliferation through inhibition of SREBP1c-mediated De novo lipogenesis in colorectal cancer cells
《BIOCELL》2024年第12期1773-1780,共8页YAJUN CAO SHUANG YIN YIDAN FANG JIEXIAN ZHOU YOUTAN LIU 
supported by Zhuhai Science and Technology Plan Project in the Field of Social Development(2320004000157);National Natural Science Foundation of China(82072215,82272219);Shenzhen Science and Technology Program(JCYJ20210324134602006);Natural Science Foundation of Guangdong Province(2214050001873).
Background: De novo lipogenesis (DNL) is a critical event for the development of tumors, in the present work,we revealed the role of propofol in colorectal cancer (CRC) cell proliferation. Methods: Western blotting (W...
关键词：PROPOFOL SREBP1c De novo lipogenesis Cell proliferation Colorectal cancer cells 
丙泊酚(propofol)
《中国合理用药探索》2024年第11期102-102,共1页
●体内过程丙泊酚是一种起效迅速(约30s)、短效的全身麻醉药,通常患者从丙泊酚麻醉中复苏迅速,具有迅速分布(半衰期2~4min)及迅速消除(半衰期30~60min)的特点。丙泊酚分布广泛,并迅速从机体消除(总体消除率1.5~2L/min)。主要通过肝脏代...
关键词：全身麻醉药 体内过程 输注速率 双异丙酚 结合物 血药浓度 肝脏代谢 消除率 
Corrigendum to:Propofol differentially induces unconsciousness and respiratory depression through distinct interactions between GABAA receptor and GABAergic neuron in corresponding nuclei
《Acta Biochimica et Biophysica Sinica》2024年第10期1572-1572,共1页Junli Jiang Yingfu Jiao Po Gao Wen Yin Wei Zhou Yunchun Zhang Yanjun Liu Daxiang Wen Yuan Wang Liang Zhou Tian Yu and Weifeng Yu 
In the version of this article initially published,an error was found in the calculation of propofol’s concentrations in electrophysiological recordings.The correct propofol concentrations used in this article is 5μ...
关键词：Cor respiratory PROPOFOL 
Ultrasound combined blood-brain barrier targeting brain delivery of four-in-one molecular aggregates for the enhancement of anesthetic efficacy and toxicity reduction via propofol-etomidate synergistically inhibition GABA receptor
《Aggregate》2024年第5期245-264,共20页Shuo Zhang Yishu Wang Mingting Zhu Bingyang Liu Wenpu Zhao Shuai Zhang Ji Xia Lei Shi Peng Tang Feiqian Wang Siyuan Zhang Mingxi Wan Daocheng Wu Wei Gao 
Young Top-notch Talents of“High-level Talents Special Support Program”of Shaanxi Province;National Natural Science Foundation of China,Grant/Award Numbers:81971290,82102074。
To enhance the anesthetic efficacy and reduce toxic side effects,a strategy is proposed involving the utilization of general anesthetics of Propofol(Pro)and Eto-midate(Eto)to synergistic inhibition GABA receptors simul...
关键词：blood-brain barrier brain delivery GABA receptor molecular aggregates synergistic anesthetic efficacy 
Effect of quantitative consciousness index on seizure parameters during electroconvulsive therapy in patients with major depressive disorder被引量：1
《World Journal of Psychiatry》2024年第9期1375-1385,共11页Bang-Shu Zhao Bi Deng Qi-Bin Chen Xiao Li You Yang Su Min 
the National Natural Science Foundation of China,No.81873798 and No.81901377;Chongqing Science and Technology Bureau Under Grant,No.cstc2019jcyj-msxmX0839.
BACKGROUND Electroconvulsive therapy(ECT)is both an effective treatment for patients with major depressive disorder(MDD)and a noxious stimulus.Although some studies have explored the effect of sedation depth on seizur...
关键词：Electroconvulsive therapy PROPOFOL NOCICEPTION DEPRESSION ELECTROENCEPHALOGRAM 
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