Effect of etomidate added to propofol target-controlled infusion in bidirectional endoscopy:A randomized clinical trial  

作　　者：Hui-Rong Luo An-Di Chen Jing-Fang Lin Peng Ye Ying-Jie Chen Ming-Xue Lin Pin-Zhong Chen Xiao-Hui Chen Xiao-Chun Zheng 

机构地区：[1]Department of Anesthesiology,Fujian Medical University Union Hospital,Fuzhou 350000,Fujian Province,China [2]Department of Anesthesiology,Shengli Clinical Medical College of Fujian Medical University,Fuzhou 350000,Fujian Province,China

出　　处：《World Journal of Gastrointestinal Endoscopy》2025年第2期55-64,共10页世界胃肠内镜杂志(英文)

摘　　要：BACKGROUND Propofol has been widely used in bidirectional gastrointestinal endoscopy sedation;however,it frequently leads to cardiovascular adverse events and respiratory depression.Propofol target-controlled infusion(TCI)can provide safe sedation but may require higher dosages of propofol.On the contrary,etomidate offers hemodynamic stability.AIM To evaluate the effect of different dose etomidate added to propofol TCI sedation during same-visit bidirectional endoscopy.METHODS A total of 330 patients from Fujian Provincial Hospital were randomly divided into three groups:P,0.1EP,and 0.15EP.Patients in the P group received propofol TCI only,with an initial effect-site concentration of the propofol TCI system of 3.0 mg/mL.Patients in the 0.1EP and 0.15EP groups received 0.1 and 0.15 mg/kg etomidate intravenous injection,respectively,followed by propofol TCI.RESULTS Patients in the 0.15EP group had higher mean blood pressure after induction than the other groups(P group:78 mmHg,0.1EP group:82 mmHg,0.15EP group:88 mmHg;P<0.05).Total doses of propofol consumption significantly decreased in the 0.15EP group compared with that in the other groups(P group:260.6 mg,0.1EP group:228.1 mg,0.15EP group:201.2 mg;P<0.05).The induction time was longer in the P group than in the other groups(P group:1.9±0.7 minutes,0.1EP group:1.2±0.4 minutes,0.15EP group:1.1±0.3 minutes;P<0.01).The recovery time was shorter in the 0.15EP group than in the other groups(P group:4.8±2.1 minutes,0.1EP group:4.5±1.6 minutes,0.15EP group:3.9±1.4 minutes;P<0.01).The incidence of hypotension(P group:36.4%,0.1EP group:29.1%,0.15EP group:11.8%;P<0.01)and injection pain was lower in the 0.15EP group than in the other groups(P<0.05).Furthermore,the incidence of respiratory depression was lower in the 0.15EP group than in the P group(P<0.05).Additionally,the satisfaction of the patient,endoscopist,and anesthesiologist was higher in the 0.15EP group than in the other groups(P<0.05).CONCLUSION Our findings suggest that 0.15 mg/kg etomidate plus propofol

关 键 词：PROPOFOL ETOMIDATE Target-controlled infusion Bidirectional endoscopy Adverse reactions 

分 类 号：R61[医药卫生—外科学]