supported by grants from the Shanghai Municipal Health Commission(2023ZDFC0203);the National Natural Science Foundation of China(32171044).
General anesthesia,pivotal for surgical procedures,requires precise depth monitoring to mitigate risks ranging from intraoperative awareness to postoperative cognitive impairments.Traditional assessment methods,relyin...
Introduction: The current recommendations for manual vacuum aspiration (MVA) for incomplete abortion, although not different in terms of effectiveness of the anesthetic techniques of choice, have still shown some inad...
Recent studies have highlighted the increase in treatment resistant depression. Of particular concern is the rising trend of depression and suicide rates among Young Adults. Ketamine was approved for treatment resista...
funded by the Taylor Family Institute for Innovative Psychiatric Research;the Bantly Foundation;MH122379 from the National Institute of Mental Health (to YI)。
The etiological factors contributing to depression and other neuropsychiatric disorders are largely undefined. Endoplasmic reticulum stress pathways and autophagy are well-defined mechanisms that play critical functio...
support from the National Natural Science Foundation of China(Grant No.42007370);the Yunnan Major Scientific and Technological Projects(Grant No.202302AO_(3)70001);the Fundamental Research Funds for the Central Universities(Grant No.YJ202315);the Yunnan Fundamental Research Projects(Grant No.202301AT070331).
The coexistence of caffeine(CF)and ketamine(KET)in surface waters across Asia has been widely reported.Previous studies have implied that CF and KET may share a mechanism of action.However,the combined toxicity of the...
Background:Estimated 4%-8%of pregnancies are complicated by asthma.Adequate management in this population is critical to minimize complications.Patients presenting with asthma exacerbation are typically managed with s...
BACKGROUND:Agitation is a common presentation within emergent departments(EDs).Agitation during pregnancy should be treated as an obstetric emergency,as the distress may jeopardize both the patient and fetus.The safet...
supported by the National Natural Science Foundation of China(82204360);STI2030-Major Projects(2021ZD0200900).
Sigma-1 receptor (S1R) is a unique multi-tasking chaperone protein in the endoplasmic reticulum. Since S1R agonists exhibit potent antidepressant-like activity, S1R has become a novel target for antidepression therapy...
The management of patients with concomitant chronic pain (CP) and Major Depressive Disorder (MDD) remains challenging for clinicians. Current chronic pharmacologic management is often unsuccessful, or has intolerable ...
supported by the National STI 2030 Major Program(2022ZD0205000);the Shanghai Municipal Science and Technology Major Project(2018SHZDZX05 to Yong Gu);the National Natural Science Foundation of China(82151314 and 81971251 to Jijun Wang).
Oculomotor behavior has been shown to be correlated with mental disorders in clinics,making it promising for disease diagnosis.Here we developed a thorough oculomotor test toolkit,involving saccade,smooth pursuit,and ...