ALLOPREGNANOLONE

作品数：7被引量：8H指数：2
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相关领域：医药卫生生物学更多>>
相关作者：于榕张鹏马千徐昕红孙臣友更多>>
相关机构：复旦大学温州医科大学复旦大学上海医学院温州医学院更多>>
相关期刊：《Acta Pharmacologica Sinica》《Virologica Sinica》《Neural Regeneration Research》更多>>
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Endoplasmic reticulum stress,autophagy,neuroinflammation,and sigma 1 receptors as contributors to depression and its treatment被引量：4
《Neural Regeneration Research》2024年第10期2202-2211,共10页Chika Fujii Charles F.Zorumski Yukitoshi Izumi 
funded by the Taylor Family Institute for Innovative Psychiatric Research;the Bantly Foundation;MH122379 from the National Institute of Mental Health (to YI)。
The etiological factors contributing to depression and other neuropsychiatric disorders are largely undefined. Endoplasmic reticulum stress pathways and autophagy are well-defined mechanisms that play critical functio...
关键词：ALLOPREGNANOLONE fluvoxamine KETAMINE NEUROSTEROIDS postpartum depression QUERCETIN 
Allopregnanolone targets nucleoprotein as a novel influenza virus inhibitor被引量：1
《Virologica Sinica》2023年第6期931-939,共9页Meiyue Dong Yanyan Wang Ping Li Zinuo Chen Varada Anirudhan Qinghua Cui Lijun Rong Ruikun Du 
the National Natural Science Foundation of China(No.82104134);the Natural Science Foundation of Shandong Province,China(No.ZR2020MH383);the Major Basic Program of Natural Science Foundation of Shandong Province(No.ZR2021ZD17);the Jinan Independent Training Innovative Team(No.2021GXRC028);the Open Research Fund Program of the State Key Laboratory of Virology of China(No.2022IOV003).
Influenza A virus(IAV)poses a global public health concern and remains an imminent threat to human health.Emerging antiviral resistance to the currently approved influenza drugs emphasizes the urgent need for new ther...
关键词：Allopregnanolone(ALLO) Antivirall Influenza A virus(IAV) NUCLEOPROTEIN Nucleus translocation 
Neurosteroids as stress modulators and neurotherapeutics: lessons from the retina被引量：1
《Neural Regeneration Research》2023年第5期1004-1008,共5页Yukitoshi Izumi Makoto Ishikawa Toru Nakazawa Hiroshi Kunikata Kota Sato Douglas F.Covey Charles F.Zorumski 
supported by MH101874, MH114866, MH122379 from the National Institute of Mental Health (to CFZ);the Taylor Family Institute for Innovative Psychiatric Research and the Bantly Foundation (to CFZ)。
Neurosteroids are rapidly emerging as important new therapies in neuropsychiatry, with one such agent, brexanolone, already approved for treatment of postpartum depression, and others on the horizon. These steroids ha...
关键词：ALLOPREGNANOLONE autophagy ENANTIOMERS EXCITOTOXICITY gamma-aminobutyric acid type A receptors glaucoma optic nerve OXYSTEROLS 
Synthetic neurosteroids on brain protection被引量：2
《Neural Regeneration Research》2015年第1期17-21,共5页Mariana Rey Héctor Coirini 
supported by grants from Agencia Nacional de Promocion Cientifica y Tecnologica(ANPCYT,PICT-2006-727);Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET,PIP-860)
Neurosteroids, like allopregnanolone and pregnanolone, are endogenous regulators of neuronal excitability. Inside the brain, they are highly selective and potent modulators of GABAA receptor activity. Their anticonvul...
关键词：ALLOPREGNANOLONE synthetic steroids GABAA receptor NEUROPROTECTION cerebral cortex HIPPOCAMPUS 
Allopregnanolone与GABA在大鼠大脑的皮层细胞中对kainate诱导乳酸脱氢酶释放的不同作用
《Acta Pharmacologica Sinica》2002年第8期680-684,共5页于榕 徐昕红 等 
目的：观察Allopregnanolone与γ氨基丁酸（BABA）对兴奋性毒性的作用。方法：对原代培养大鼠大脑的皮层细胞，采用kainate(KA)处理，诱导发兴奋性毒性，通过测定释放至细胞培养基中的乳酸盐脱氢酶（LDH）活性，观察Allopregnanolone与G...
关键词：别孕烷醇酮 神经固醇 兴奋性毒性 大鼠 大脑 皮层细胞 乳酸脱氢酶释放 作用 GABAA受体 
Synergistic protection of allopregnanolone and phenobarbital against maximal electroshock seizures in mice
《Acta Pharmacologica Sinica》2001年第4期75-78,共4页鲁映青 于榕 
Project supported by the Science and Technology Foundation of Shanghai Education Committee, № 99JG05049.
AIM: To examine the interactions of allopregnanolone and phenobarbital for the protection against seizures. METHODS: The protective activity of allopregnanolone and/or phenobarbital against seizures was studied in the...
关键词：STEROIDS ALLOPREGNANOLONE PHENOBARBITAL drug synergism CONVULSIONS GABAA receptors 
Anticonvulsant activity of allopregnanolone against pentylenetetrazol- induced seizures in rodents
《现代康复》2001年第1期155-155,157,共2页鲁映青 于榕 
Objective To examine the protective effects of allopregnanolone against pentylenetetrazol－ induced seizures. Methods The protective effects of allopregnanolone against pentylenetetrazol－ induced seizures were studie...
关键词：别孕烯醇酮 卡地阿性 ED50 癫痫发作 
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