Anticonvulsant activity of allopregnanolone against pentylenetetrazol- induced seizures in rodents  

作　　者：鲁映青 于榕 

机构地区：[1]Medical [2]Center

出　　处：《现代康复》2001年第1期155-155,157,共2页Modern Rehabilitation

摘　　要：Objective To examine the protective effects of allopregnanolone against pentylenetetrazol－ induced seizures. Methods The protective effects of allopregnanolone against pentylenetetrazol－ induced seizures were studied in C57 mice and SD rats 15 minutes after vehicle or drug intraperitoneal (ip) administration. Results The pretreatment with the allopregnanolone produced a dose－ dependent protective effect against pentylenetetrazol－ induced seizures. The potencies (ED50 values) were 4.7 mg/kg and 9.8 mg/kg for mice and rats, respectively. Conclusion Allopregnanolone has anticonvulsant activity against pentylenetetrazol－ induced seizures in rodents.Objective To examine the protective effects of allopregnanolone against pentylenetetrazol－ induced seizures. Methods The protective effects of allopregnanolone against pentylenetetrazol－ induced seizures were studied in C57 mice and SD rats 15 minutes after vehicle or drug intraperitoneal (ip) administration. Results The pretreatment with the allopregnanolone produced a dose－ dependent protective effect against pentylenetetrazol－ induced seizures. The potencies (ED50 values) were 4.7 mg/kg and 9.8 mg/kg for mice and rats, respectively. Conclusion Allopregnanolone has anticonvulsant activity against pentylenetetrazol－ induced seizures in rodents.

关 键 词：别孕烯醇酮 卡地阿性 ED50 癫痫发作 

分 类 号：R742.1[医药卫生—神经病学与精神病学]