Allopregnanolone targets nucleoprotein as a novel influenza virus inhibitor  

作　　者：Meiyue Dong Yanyan Wang Ping Li Zinuo Chen Varada Anirudhan Qinghua Cui Lijun Rong Ruikun Du 

机构地区：[1]Innovative Institute of Chinese Medicine and Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan,250355,China [2]College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan,250355,China [3]Department of Microbiology and Immunology,College of Medicine,University of Illinois at Chicago,Chicago,60612,USA [4]Qingdao Academy of Chinese Medical Sciences,Shandong University of Traditional Chinese Medicine,Qingdao,266122,China

出　　处：《Virologica Sinica》2023年第6期931-939,共9页中国病毒学（英文版）

基　　金：the National Natural Science Foundation of China(No.82104134);the Natural Science Foundation of Shandong Province,China(No.ZR2020MH383);the Major Basic Program of Natural Science Foundation of Shandong Province(No.ZR2021ZD17);the Jinan Independent Training Innovative Team(No.2021GXRC028);the Open Research Fund Program of the State Key Laboratory of Virology of China(No.2022IOV003).

摘　　要：Influenza A virus(IAV)poses a global public health concern and remains an imminent threat to human health.Emerging antiviral resistance to the currently approved influenza drugs emphasizes the urgent need for new therapeutic entities against IAV.Allopregnanolone(ALLO)is a natural product that has been approved as an antidepressant drug.In the present study,we repurposed ALLO as a novel inhibitor against IAVs.Mechanistic studies demonstrated that ALLO inhibited virus replication by interfering with the nucleus translocation of viral nucleoprotein(NP).In addition,ALLO showed significant synergistic activity with compound 16,a hemagglutinin inhibitor of IAVs.In summary,we have identified ALLO as a novel influenza virus inhibitor targeting NP,providing a promising candidate that deserves further investigation as a useful anti-influenza strategy in the future.

关 键 词：Allopregnanolone(ALLO) Antivirall Influenza A virus(IAV) NUCLEOPROTEIN Nucleus translocation 

分 类 号：R285[医药卫生—中药学]