NUCLEOPROTEIN

作品数：24被引量：66H指数：5
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相关领域：医药卫生农业科学更多>>
相关机构：中国科学院上海生命科学研究院更多>>
相关期刊：《Food and Nutrition Sciences》《Asian Pacific Journal of Tropical Biomedicine》《Journal of Biosciences and Medicines》《Open Journal of Medicinal Chemistry》更多>>
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Allopregnanolone targets nucleoprotein as a novel influenza virus inhibitor被引量：1
《Virologica Sinica》2023年第6期931-939,共9页Meiyue Dong Yanyan Wang Ping Li Zinuo Chen Varada Anirudhan Qinghua Cui Lijun Rong Ruikun Du 
the National Natural Science Foundation of China(No.82104134);the Natural Science Foundation of Shandong Province,China(No.ZR2020MH383);the Major Basic Program of Natural Science Foundation of Shandong Province(No.ZR2021ZD17);the Jinan Independent Training Innovative Team(No.2021GXRC028);the Open Research Fund Program of the State Key Laboratory of Virology of China(No.2022IOV003).
Influenza A virus(IAV)poses a global public health concern and remains an imminent threat to human health.Emerging antiviral resistance to the currently approved influenza drugs emphasizes the urgent need for new ther...
关键词：Allopregnanolone(ALLO) Antivirall Influenza A virus(IAV) NUCLEOPROTEIN Nucleus translocation 
Nonmuscle myosin IIA promotes the internalization of influenza A virus and regulates viral polymerase activity through interacting with nucleoprotein in human pulmonary cells被引量：2
《Virologica Sinica》2023年第1期128-141,共14页Jian Chen Jian Liu Zhilu Chen Daobin Feng Cuisong Zhu Jun Fan Shuye Zhang Xiaoyan Zhang Jianqing Xu 
supported by the National Natural Science Foundation of China(82071788,81901598,81771704,and 82041015);National Key R&D Program of China(2022YFC2604100).
Influenza A virus(IAV),responsible for seasonal epidemics and recurring pandemics,represents a global threat to public health.Given the risk of a potential IAV pandemic,it is increasingly important to better understan...
关键词：Myosin IIA(MYH9) Influenza A virus(IAV) vRNP activity Virus-host interactions Virus entry 
Generation and application of two monoclonal antibodies targeting conserved linear epitopes in the NP protein of influenza A virus被引量：2
《Journal of Integrative Agriculture》2022年第7期2095-2105,共11页ZHAO Yu-hui WEN Xia LI Qi-bing JIANG Li WANG Guang-wen LIANG Li-bin WANG Xiu-rong CHEN Hua-lan LI Cheng-jun 
supported by the Natural Science Foundation of Heilongjiang Province,China(JQ2019C005);the National Natural Science Foundation of China(31702265 and 32172847)。
Monoclonal antibodies(mAbs) are widely used in virus research and disease diagnosis. The nucleoprotein(NP) of influenza A virus(IAV) plays important roles in multiple stages of the virus life cycle. Therefore, generat...
关键词：influenza A virus NUCLEOPROTEIN monoclonal antibody application 
Extracellular nucleoprotein exacerbates influenza viruspathogenesis by activating Toll-like receptor 4 and the NLRP3inflammasome被引量：5
《Cellular & Molecular Immunology》2022年第6期715-725,共11页Chang-Ung Kim Yu-Jin Jeong Pureum Lee Moo-Seung Lee Jong-Hwan Park Young-Sang Kim Doo-Jin Kim 
This work was supported by grants from the Bio&Medical Technology Development Program of the National Research Foundation of Korea(NRF)(2018M3A9H4077992);the KRIBB Initiative program(KGM9942112)funded by the Korean government(Ministry of Science&ICT).
Host immune responses, such as those initiated by pattern recognition receptor (PRR) activation, are important for viralclearance and pathogenesis. However, little is known about the interactions of viral proteins wit...
关键词：Influenza virus Viral protein release NUCLEOPROTEIN Toll-like receptor Cyotkine-trypsin cycle 
The two-stage interaction of Ebola virus VP40 with nucleoprotein results in a switch from viral RNA synthesis to virion assembly/ budding
《Protein & Cell》2022年第2期120-140,共21页Linjuan Wu Dongning Jin Dan Wang Xuping Jing Peng Gong Yali Qin Mingzhou Chen 
We acknowledge Dr.Bo Zhang(Wuhan Institute of Virology)and Dr.Heinz Feldmann(National Institutes of Health,Hamilton,Montana,USA)for providing the Ebola cDNA and minigenome assay system,respectively;This research is supported by grants from the National Natural Science Foundation of China(81825015);National Key R&D Program of China(2017YFA0505801);National Science and Technology Major Project(2018ZX10101004);National Natural Science Foundation of China(81871650 and 31630086);The Natural Science Foundation of Hubei Province Innovation Group(2017CFA022);Advanced Customer Cultivation Project of Wuhan National Biosafety Laboratory(2019ACCP-MS06).
Ebola virus(EBOV)is an enveloped negative-sense RNA virus and a member of the filovirus family.Nucleoprotein(NP)expression alone leads to the formation of inclusion bodies(IBs),which are critical for viral RNA synthes...
关键词：Ebola virus NUCLEOPROTEIN matrix protein two-stage interaction RNA synthesis NUCLEOCAPSID assembly/budding 
Immunoglobulin G Specific Antibody Level against Ebola Viral Glycoprotein and Nucleoprotein in Ebola Virus Disease Survivors and Their Relatives
《Journal of Biosciences and Medicines》2021年第4期179-196,共18页Nadège Goumkwa Mafopa Raoul Emeric Guetiya Wadoum Marta Giovanetti Antonella Minutolo Béatrice Dambaya Claude Kwe Yinda Gianluca Russo Georges Teto Georgia Ambada Patrick Turay Judith Torimiro Alexis Ndjolo Jules Roger Kuate Vittorio Colizzi Carla Montesano 
Ebola virus disease is a complex zoonosis that is highly virulent in humans. Despite its sorely pathogenic and lethal nature, survivors of this infection and even asymptomatic cases are able to develop both humoral an...
关键词：Immunoglobulin IgG Level Ebola Survivors and Relatives Glycoprotein and Nucleoprotein 
Nucleoprotein phosphorylation site(Y385)mutation confers temperature sensitivity to influenza A virus due to impaired nucleoprotein oligomerization at a lower temperature被引量：2
《Science China(Life Sciences)》2021年第4期633-643,共11页Weinan Zheng Liang Cui Minghui Li Yun Li Wenhui Fan Limin Yang Jing Li Lei Sun Wenjun Liu 
supported by grants from the Strategic Priority Research Program of Chinese Academy of Sciences(XDB29010000);the National Natural Science Foundation of China(31630079,31972657,31672531);the National Key Research and Development Program of China(2016YFD0500206);the Mega-Project of Guangxi Natural Science Foundation(2015GXNSFEA139002);supported by Youth Innovation Promotion Association of CAS(2019091)。
Mutations in viral proteins can lead to the cold adaption of influenza A virus and the cold-adapted virus is an important vaccination instrument.Here,we identify a novel strain of influenza A virus with cold sensitivi...
关键词：influenza A virus NUCLEOPROTEIN PHOSPHORYLATION DEPHOSPHORYLATION temperature sensitivity 
Retroviral integrase protein and intasome nucleoprotein complex structures被引量：2
《World Journal of Biological Chemistry》2017年第1期32-44,共13页Julia Grawenhoff Alan N Engelman 
Supported by United States National Institutes of Health grant,No.R01AI070042
Retroviral replication proceeds through the integration of a DNA copy of the viral RNA genome into the host cellular genome, a process that is mediated by the viral integrase(IN) protein. IN catalyzes two distinct che...
关键词：DNA integration 3-dimensional structure INTEGRASE Intasome Mouse mammary tumor virus RETROVIRUS Rous sarcoma virus Prototype foamy virus Human immunodeficiency virus/acquired immune deficiency syndrome 
Evaluation of Benzamide Derivatives as New Influenza A Nucleoprotein Inhibitors被引量：1
《Open Journal of Medicinal Chemistry》2016年第3期43-50,共8页Jinxi Liao Huimin Cheng Junting Wan Panyu Chen Yingjun Li Ke Ding Micky D. Tortorella Zhengchao Tu Yanmei Zhang 
Virus nucleoprotein (NP) is an emerging target for drug development for Influenza. We designed benzamide derivatives as new inhibitors of NP that demonstrate good potency in blocking influenza A. Screening revealed th...
关键词：BENZAMIDES NUCLEOPROTEIN ANTI-INFLUENZA NP Inhibitors Nucleozin 
Phosphorylation sites within Ebola virus nucleoprotein
《Asian Pacific Journal of Tropical Biomedicine》2015年第7期587-588,共2页Sora Yasri Viroj Wiwanitkit 
To understand the infection process, the viral multiplication and entry to the cell is widely studied. The Ebola virus nucleoprotein is the important problem for the pathological process. Focusing on the specific biol...
关键词：PHOSPHORYLATION EBOLA VIRUS NUCLEOPROTEIN 
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