云南高校图书馆联盟文献共享服务平台- DEPHOSPHORYLATION

DEPHOSPHORYLATION: 作品数：49被引量：240H指数：9; 导出分析报告; 相关领域：生物学更多>>; 相关作者：孟安明陈晔光彭咏波刘群李萍更多>>; 相关机构：清华大学南方医科大学第三附属医院中国药科大学汕头大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金天津市自然科学基金湖北省自然科学基金中国博士后科学基金更多>>

Engineering cellular dephosphorylation boosts(+)-borneol production in yeast: 《Acta Pharmaceutica Sinica B》2025年第2期1171-1182,共12页Haiyan Zhang Peng Cai Juan Guo Jiaoqi Gao Linfeng Xie Ping Su Xiaoxin Zhai Baolong Jin Guanghong Cui Yongjin J.Zhou Luqi Huang; supported by National Key R&D Program of China(2020YFA0908000);the CACMS Innovation Fund(CI2021A04109,CI2023D002,China);Key project at central government level:the ability to establish sustainable use of valuable Chinese Medicine Resources(2060302,China).; (+)-Borneol,the main component of"Natural Borneol"in the Chinese Pharmacopoeia,is a high-end spice and precious medicine.Plant extraction cannot meet the increasing demand for(+)-borneol,while microbial biosynthesis o...; 关键词：BORNEOL MONOTERPENE LPP1 DPP1 Nudix hydrolase PHOSPHATASE

Erratum to“PGAM5-Mediated PHB2 Dephosphorylation Contributes to Diabetic Cardiomyopathy by Disrupting Mitochondrial Quality Surveillance”: 《Research》2024年第4期431-432,共2页Rongjun Zou Jun Tao Jie He Chaojie Wang Songtao Tan Yu Xia Xing Chang Ruibing Li Ge Wang Hao Zhou Xiaoping Fan; In the Research Article“PGAM5-mediated PHB2 dephosphorylation contributes to diabetic cardiomyopathy by disrupting mitochondrial quality surveillance”[1],an inadvertent error was discovered where one image was mista...; 关键词：PHB2 H. PHOSPHORYLATION

Enzyme-modulate conformational changes in amphiphile peptide for selectively cell delivery: 《Chinese Chemical Letters》2024年第12期245-248,共4页Weiyu Chen Zenghui Li Chenguang Zhao Lisha Zha Junfeng Shi Dan Yuan; supported by the National Natural Science Foundation of China(No.21975068);Natural Science Foundation of Hunan(No.2022JJ10008);Science and Technology and Development Foundation of Shenzhen(No.JCYJ20210324122403010);Natural Science Foundation of Changsha(No.kq2202152)。; Achieving selectivity in cell penetrating peptide(CPP)design is crucial to mitigate systemic toxicity and enable precise targeting based on distinct cellular phenotypes.Herein,we designed an amphiphilic peptide,L17Yp,...; 关键词：Enzymatic action DEPHOSPHORYLATION Conformation shift Cell-penetrating peptide Selective delivery

A new tau dephosphorylation-targeting chimera for the treatment of tauopathies: 《Acta Pharmacologica Sinica》2024年第11期2267-2276,共10页Jing-fen Su Yue Xiao Lin-yu Wei Hui-yang Lei Fei Sun Wei-xia Wang Shi-hong Li Xiao-chuan Wang Jie Zheng Jian-zhi Wang; supported by the National Natural Science Foundation of China(No.82230041,91949205);Sanming Project of Medicine in Shenzhen(No.SZSM202211010);Guangdong Provincial Key S&T Program(No.2018B030336001),Peking University Talent Startup Fund(No.BMU2022YJ003);supported by the“Fundamental Research Funds for the Central Universities”,Scientific Project of Beijing Life Science Academy(No.2024300CC0020).; Abnormal accumulation of hyperphosphorylated tau protein plays a pivotal role in a collection of neurodegenerative diseases named tauopathies,including Alzheimer’s disease(AD).We have recently conceptualized the desi...; 关键词：TAU dephosphorylation targeting chimera(DEPTAC) TAUOPATHY Alzheimer’s disease drug development

Author Correction:A new tau dephosphorylation-targeting chimera for the treatment of tauopathies: 《Acta Pharmacologica Sinica》2024年第11期2453-2454,共2页Jing-fen Su Yue Xiao Lin-yu Wei Hui-yang Lei Fei Sun Wei-xia Wang Shi-hong Li Xiao-chuan Wang Jie Zheng Jian-zhi Wang; Correction to:Acta Pharmacologica Sinica(2024)0:1-10;https://doi.org/10.1038/s41401-024-01326-4,published online 02 July 2024 The authors would like to apologize for the errors in the previously published images of Fi...; 关键词：checked FIGURES FUSED

Abrogation of nuclear entry of TERT by fructose 1,6-bisphosphatase 1-mediated dephosphorylation: 《Cancer Communications》2024年第10期1102-1105,共4页Pengbo Yao Gaoxiang Zhao Min Li Wensheng Qiu Zhimin Lu; the Ministry of Science and Technology of the People’s Republic of China,Grant/Award Number:2020YFA0803300;National Center of Technology Innovation for Biopharmaceuticals,Grant/Award Number:NCTIB2022HS02006;Taishan Scholar Project from Shandong province,Grant/Award Number:tsqn202312174;National Natural Science Foundation of China,Grant/Award Numbers:82030074,82103351,82188102。; Telomeres maintain chromosome integrity.Loss of telomere function,which is attributed to progressively shortened telomeres in each round of DNA replication,induces endto-end fusion of chromosomes,anaphase bridges with...; 关键词：eventually BRIDGES MAINTAIN

Timosaponin AⅢ induces drug-metabolizing enzymes by activating constitutive androstane receptor (CAR) via dephosphorylation of the EGFR signaling pathway被引量：1: 《Journal of Biomedical Research》2024年第4期382-396,共15页Muhammad Zubair Hafiz Jie Pan Zhiwei Gao Ying Huo Haobin Wang Wei Liu Jian Yang; supported by the National Natural Science Foundation of China(Grant Nos.82073934,81872937,and 81673513).; The current study aimed to assess the effect of timosaponin AⅢ(T-AⅢ)on drug-metabolizing enzymes during anticancer therapy.The in vivo experiments were conducted on nude and ICR mice.Following a 24-day administratio...; 关键词：timosaponin AⅢ CAR metabolism enzyme ERK1/2 signaling pathway EGFR signaling pathway

多肽靶向嵌合体通过促进tau蛋白特异性去磷酸化治疗阿尔茨海默病和其他tau蛋白病被引量：1: 《Science Bulletin》2024年第8期1137-1152,共16页苏静芬肖越魏林郁雷慧杨孙飞王围霞尹君熊瑞李师宏张配周颖王小川郑杰王建枝; supported by the National Natural Science Foundation of China(82230041,91949205,31730035,81721005);the National Key R&D Program of China(2016YFC1305800);the Guangdong Provincial Key S&T Program(018B030336001)。; Abnormal hyperphosphorylation and accumulation of tau protein play a pivotal role in neurodegeneration in Alzheimer’s disease(AD)and many other tauopathies.Selective elimination of hyperphosphorylated tau is promisin...; 关键词：TAU Dephosphorylation-targeting chimeras Therapeutic potential TAUOPATHY

Development of tau phosphorylation-targeting therapies for the treatment of neurodegenerative diseases: 《Medicine Plus》2024年第4期58-72,共15页Jingfen Su Yue Xiao Xiaochuan Wang Jie Zheng Jian-Zhi Wang; supported by the National Natural Science Foundation of China (82230041, 91949205, 31730035, and 81721005);the National Key R&D Program of China (2016YFC1305800);the Guangdong Provincial Key S&T Program (018B030336001); Hyperphosphorylation of microtubule-associated protein tau is a major driver in the etiology of multiple neurodegenerative diseases, such as Alzheimer's disease(AD)and other tauopathies. Intracellular accumulation of ...; 关键词：TAU PHOSPHORYLATION Drug discovery Dephosphorylation-targeting chimera

Damage Mechanism of CK2 and IKAROS in Philadelphia Like Acute Lymphoblastic Leukemia: 《Journal of Biosciences and Medicines》2024年第4期49-59,共11页Ignacio Vélez-Rodríguez Victoria Carranza-Aranda; Acute lymphoblastic leukemia (ALL) is characterized by immature and poorly differentiated B lymphocytes in large numbers in the blood. B cells are distinct from the cell types involved in their development (common lym...; 关键词：Acute Lymphoblastic Leukemia IKAROS DEPHOSPHORYLATION Philadelphia Chromosome CK2

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