ANTI-INFLUENZA

作品数：20被引量：45H指数：4
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Emerging drug design strategies in anti-influenza drug discovery被引量：2
《Acta Pharmaceutica Sinica B》2023年第12期4715-4732,共18页Chuanfeng Liu Lide Hu Guanyu Dong Ying Zhang Edeildo Ferreira da Silva-Jinior Xinyong Liu Luis Menendez-Arias Peng Zhan 
financial support from the National Natural Science Foundation of China(NSFC No.82173677);the Science Foundation for Outstanding Young Scholars of Shandong Province(ZR2020JQ31,China);the China Postdoctoral Science Foundation(2022M711938);supported in part by the Ministry of Science and Innovation of Spain through grant PID2019-104176RB-I00/AEI/10.13039/501100011033 awarded to Luis Menendez-Arias-A.
Influenza is an acute respiratory infection caused by influenza viruses(IFV),According to the World Health Organization(WHO),seasonal IFV epidemics result in approximately 3-5 million cases of severe illness,leading t...
关键词：Influenza virus Drug design strategies Anti-drugresistance High efficiency Broad spectrum 
Pharmacological Action and Mechanism of Dendrobine
《Medicinal Plant》2023年第6期88-90,98,共4页Jingjing WEN Wenshuang HOU Anqi WANG Jiazhu LI Jundong GUAN Zhe LIU Changtao CAI Chenghao JIN 
Supported by The Central Talent Training Project for Local University Reform and Development(2020GSP16);Guidance Project of Key R&D Plan in Heilongjiang Province(GZ20220039);Innovative Research Project for Postgraduates of Heilongjiang Bayi Agricultural University(YJSCX2022-Y55).
Dendrobine,an alkaloid extracted from the stem of Dendrobium nobile Lindl.,has many biological activities such as anti-cancer effect,anti-inflammation effect,anti-influenza A virus effect,treatment of leukemia,treatme...
关键词：DENDROBINE ANTI-CANCER ANTI-INFLAMMATION Anti-influenza A virus Leukemia treatment 
Facile Synthesis of Amino Acid Decorated Water-Soluble Fullerene Derivatives with Anti-influenza Activity
《Chinese Journal of Chemistry》2023年第15期1803-1808,共6页Valeriya S.Bolshakova Ekaterina O.Sinegubova Yana L.Esaulkova Alexander S.Peregudov Ekaterina A.Khakina Nikita A.Slesarenko Alexander F.Shestakov Vladimir V.Zarubaev Pavel A.Troshin Olga A.Kraevaya 
Russian Science Foundation(19-13-00411-P);O.A.K.acknowledges the support from the Stipend of the President of Russian Federation(SP-2022).
Comprehensive Summary Herein,we present a facile synthesis of amide-type water-soluble fullerene derivatives decorated with five residues of amino acids.As compared to the previously developed approaches,the proposed ...
关键词：FULLERENES Amino acids Regioselectivity Water-solublel Influenza ANTIVIRAL 
Multi-Omics-Guided Discovery of Omicsynins Produced by Streptomyces sp.1647:Pseudo-Tetrapeptides Active Against Influenza A Viruses and Coronavirus HCoV-229E被引量：1
《Engineering》2022年第9期176-186,共11页Hongmin Sun Xingxing Li Minghua Chen Ming Zhong Yihua Li Kun Wang Yu Du Xin Zhen Rongmei Gao Yexiang Wu Yuanyuan Shi Liyan Yu Yongsheng Che Yuhuan Li Jian-Dong Jiang Bin Hong Shuyi Si 
supported by the National Natural Science Foundation of China(81630089,81703398,81872780,and 81803410);the Beijing Natural Science Foundation,China(7214286);the Drug Innovation Major Project of China(2018ZX09711001-006-011,2018ZX09735001-002,and 2018ZX09711001-007);the CAMS Innovation Fund for Medical Sciences(2018-I2M-3-005 and 2020-I2M-2-010)。
Many microorganisms have mechanisms that protect cells against attack from viruses.The fermentation components of Streptomyces sp.1647 exhibit potent anti-influenza A virus(IAV)activity.This strain was isolated from s...
关键词：Multi-omics Anti-influenza A virus Anti-coronavirus Streptomyces sp.1647 Pseudo-tetrapeptides 
Discovery of the anti-influenza A virus activity of SB216763 and cyclosporine A by mining infected cells and compound cellular signatures被引量：1
《Chinese Chemical Letters》2022年第5期2541-2544,共4页Ke Tang You Wu Shubing Chen Yijing Xin Ying Guo 
supported by the CAMS Innovation Fund for Medical Sciences (Nos. 2021-I2M-1-028 and 2020I2M-2-010);the Opening Foundation of the State Key Laboratory of Bioactive Substance and Function of Natural Medicines (No. GTZK202109);the National Natural Science Foundation of China (No. 81473256);the Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study (No. BZ0150);the Disciplines Construction Project (No. 201920200802)
In this study,SB216763 and cyclosporine A were identified as anti-influenza A virus(IAV)agents by tran-scriptome signature reversion(TSR)analysis through deep mining of the cellular transcriptome of hu-man airway and ...
关键词：Chemical perturbagen signature Host factor Transcriptome signature reversion Influenza A virus SB216763 Cyclosporine A Drug combination 
Sheng Jiang San, traditional multi-herb formulation, exerts anti-influenza effects in vitro and in vivo via neuraminidaseinhibition and immune regulation
《中国药理学与毒理学杂志》2019年第9期738-739,共2页ZHANG Tian-bo XIAO Meng-jie Chun-Kwok WONG Ka-Pun CHRIS MOK ZHAO Xin TI Hui-hui Pang-Chui SHAW 
OBJECTIVE Sheng Jiang San(SJS),a multi-herb formulation,is used in treating high fever,thirsty and anxiety in ancient China and it is sometimes used to treat seasonal influenza in modern.However,there is no evidenceba...
关键词：Sheng Jiang San anti-influenza activity neuraminidase inhibition immuno-regulation 
Anti-influenza effect and action mechanisms of the chemical constituent gallocatechin-7-gallate from Pithecellobium clypearia Benth被引量：9
《Acta Pharmacologica Sinica》2018年第12期1913-1922,共10页Chao Li Lv-jie Xu Wen-wen Lian Xiao-cong Pang Hao Jia Ai-lin Liu Guan-hua Du 
the National Natural Science Foundation of China {81673480);the Beijing Natural Science Foundation (7152103);the CAMS Initiative for Innovative Medicine (CAMS-12M;2016-12M-3-007);the National Great Science and Technology Projects (2012ZX09301002-2013HXW-11,2014ZX09507003-002); the International Collaboration Project (2011DFR31240).
Host cdc2-like kinase 1 (CLK1) is responsible for the alternative splicing of the influenza virus M2 gene during influenza virus infection and replication that has been recognized as a potential anti-influenza virus t...
关键词：INFLUENZA VIRUS cdc2-like KINASE 1 gallocatechin-7-gallate Pithecellobium clypearia Benth traditional Chinese medicine 
Research progress of siRNA in anti-influenza viral infection
《国际感染病学（电子版）》2018年第2期50-55,共6页Li Han 
The harms of seasonal flu and global pandemic influenza have generally attracted attention. However, the currently administered influenza drugs and flu vaccines have certain limitations. Since the discovery of the sma...
关键词：季节性流感 流行病 治疗方法 预防措施 
Additive Effects of Water-Soluble Propolis(Greit 120)and Human Interferon Alfa(HuIFN-αN3)against Influenza Viruses in Vitro
《Journal of Agricultural Science and Technology(A)》2018年第1期36-47,共12页Bratko Filipic Lidija Gradisnik Adriana Pereyra Rok Kopino Klemen Rihar Eva Ruzic-Sabljic Snezana Kramar Damir Dermie Eugen Soos Nicola Volpi Alfredo Fachini and Hrvoje Mazija 
Influenza virus affects the respiratory tract in humans causing a range of distinct manifestations including fever, nasal secretions, cough, headaches, muscle pain and pneumonia, which could become violent and severe...
关键词：Water-soluble propolis Greit 120 HuIFN-αN3 anti-influenza activity ribavirin ID_(50) 
Screening and evaluation of commonly-used anti-influenza Chinese herbal medicines based on anti-neuraminidase activity被引量：6
《Chinese Journal of Natural Medicines》2016年第10期794-800,共7页HAN Xue ZHANG Ding-Kun GUO Yu-Ming FENG Wu-Wen DONG Qin ZHANG Cong-En ZHOU Yong-Feng LIU Yan WANG Jia-Bo ZHAO Yan-Ling XIAO Xiao-He YANG Ming 
supported by the National Natural Science Foundation of China(Nos.81274026,81403126,81330090,81573676)
Anti-influenza Chinese herbal medicines(anti-flu CHMs) have advantages in preventing and treating influenza virus infection. Despite various data on antiviral activities of some anti-flu CHMs have been reported, most ...
关键词：ANTI-INFLUENZA Chinese herbal medicines Viral neuraminidase BIOASSAY SCREENING Evaluation 
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