云南高校图书馆联盟文献共享服务平台- BENZAMIDES

BENZAMIDES: 作品数：10被引量：8H指数：2; 导出分析报告; 相关领域：理学医药卫生更多>>; 相关作者：魏俊发董雪芬石先莹王佰全更多>>; 相关机构：南开大学陕西师范大学更多>>; 相关期刊：《Science China Chemistry》《World Journal of Gastroenterology》《International Journal of Organic Chemistry》《Chinese Journal of Chemistry》更多>>; 相关基金：国家自然科学基金高等学校学科创新引智计划天津市自然科学基金中央高校基本科研业务费专项资金更多>>

Discovery of 4-cyclopropyl-3-(2-((1-cyclopropyl-1H-pyrazol-4-yl) amino) quinazolin-6-yl)-N-(3-(trifluoromethyl) phenyl) benzamides as potent discoidin domain receptor inhibitors for the treatment of idiopathic pulmonary fibrosis被引量：1: 《Acta Pharmaceutica Sinica B》2022年第4期1943-1962,共20页Qi Wang Bixi Tang Dandan Sun Ying Dong Yinchun Ji Huanyu Shi Liwei Zhou Yueyue Yang Menglan Luo Qian Tan Lin Chen Yue Dong Cong Li Rongrong Xie Yi Zang Jingkang Shen Bing Xiong Jia Li Danqi Chen; This research has been financially supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA12020323);the National Science&Technology Major Project“Key New Drug Creation and Manufacturing Program”of China(Grant No.2018ZX09711002-004-009);the Strategic Priority Research Program of Chinese Academy of Sciences(No.SIMM010203);Institutes for Drug Discovery and Development,Chinese Academy of Sciences(No.CASIMM0120215009);National Natural Science Foundation of China(No.U1703235);Shanghai Science and Technology Development Funds(18431907100,China).; Idiopathic pulmonary fibrosis(IPF)is a chronic fatal lung disease with a median survival time of 3–5 years.Inaccurate diagnosis,limited clinical therapy and high mortality together indicate that the development of ef...; 关键词：Idiopathic pulmonary fibrosis Discoidin domain receptor Kinase Inhibitor Docking

Benzylic aroylation of toluenes with unactivated tertiary benzamides promoted by directed ortho-lithiation: 《Science China Chemistry》2021年第8期1349-1354,共6页Can-Can Bao Yan-Long Luo Hui-Zhen Du Bing-Tao Guan; This work was supported by the Natural Science Foundation of Tianjin(19JCYBJC20100).; The deprotonative functionalization of toluenes,for their weak acidity,generally needs strong bases,thus leading to the requirement of harsh conditions and the generation of by-products.Direct nucleophilic acyl substi...; 关键词：TOLUENE aroylation unactivated tertiary benzamides directed ortho-lithiation nucleophilic acyl substitution reaction

Selective annulation of benzamides with internal alkynes catalyzed by an electron-deficient rhodium catalyst: 《Chinese Chemical Letters》2021年第5期1717-1720,共4页Ping Zhang Wenju Chang Hongyun Jiao Yanshang Kang Wenxuan Zhao Peipei Cui Yong Liang Wei-Yin Sun Yi Lu; We gratefully acknowledge the National Natural Science Foundation of China(Nos.21671097 and 21573106);the Fundamental Research Funds for the Central Universities for financial support.; An electron-deficient[CpERhCl2]2 catalyzed annulation of N-pentafluorophenylbenzamides with internal alkynes was successfully established under mild reaction conditions,with the assistance of Lewis acid silver salt.Pa...; 关键词：Electron-deficient rhodium C—H activation ANNULATION BENZAMIDE ALKYNE

Evaluation of Benzamide Derivatives as New Influenza A Nucleoprotein Inhibitors被引量：1: 《Open Journal of Medicinal Chemistry》2016年第3期43-50,共8页Jinxi Liao Huimin Cheng Junting Wan Panyu Chen Yingjun Li Ke Ding Micky D. Tortorella Zhengchao Tu Yanmei Zhang; Virus nucleoprotein (NP) is an emerging target for drug development for Influenza. We designed benzamide derivatives as new inhibitors of NP that demonstrate good potency in blocking influenza A. Screening revealed th...; 关键词：BENZAMIDES NUCLEOPROTEIN ANTI-INFLUENZA NP Inhibitors Nucleozin

Regioselectivity Differentiation in Metalations of 3,5-Dichloro-Tertiary versus Secondary Benzamides: 《International Journal of Organic Chemistry》2016年第2期142-146,共5页Francesca Khani Tina Fleming Carleton Collins Erica Tabakin Lynn M. Bradley David A. Hunt; Metalation regioslectivity of 3,5-dichlorobenzamides is a function of the type of amide (secondary versus tertiary) used in the sequence. Metalation at the 2-position (adjacent to the carboxamide functional group) occ...; 关键词：Directed Ortho-Metalation Complex-Induced Proximity Effects (CIPE) 3 5-Dichlorobenzamides

Ru(Ⅱ)-catalyzed ortho-amidation and decarboxylation of aromatic acids: a versatile route to meta-substituted N-aryl benzamides被引量：1: 《Science China Chemistry》2015年第8期1286-1291,共6页Xian-Ying Shi Xue-Fen Dong Juan Fan Ke-Yan Liu Jun-Fa Wei Chao-Jun Li; supported by the National Natural Science Foundation of China(20906059,21272145);the Shaanxi Innovative Team of Key Science and Technology(2013KCT-17);the Fundamental Research Funds for the Central Universities(GK201503030,GK261001095);the 111 Project,and Canada Research Chair(to CJL); Carboxylate as a promising and valuable directing group has attracted a great deal of attention.However,employing it as a traceless direction group has rarely been reported.We developed the ruthenium-catalyzed amidati...; 关键词：AMIDES DECARBOXYLATION AMIDATION C-H functionalization homogeneous catalysis

Synthesis of novel substituted N-aryl benzamides as hA3G stabilizers and their inhibitory activities against hepatitis C virus replication被引量：2: 《Acta Pharmaceutica Sinica B》2013年第5期312-321,共10页Yanping Li Zonggen Peng Lanhu Hao Zhouyi Wu Yanping Zhu Laixing Hu Jiandong Jiang Zhuorong Li; supported by the National Natural Science Foundation of China(Grants 30873138,81202414).; A series of novel amino-substituted N-aryl benzamide analogs were synthesized and evaluated for their ability to inhibit hepatitis C virus(HCV)replication in acutely infected Huh7.5 cells.Most of the substituted N-ary...; 关键词：N-aryl benzamide hA3G HCV inhibitor Structure–activity relationship

Synthesis and Bioactivities of Novel N-（4-（2-Aryloxythiazol- 5-yl）but-3-yn-2-yl）benzamides: 《Chinese Journal of Chemistry》2013年第2期173-181,共9页Youquan Zhu Pei Liu Danyang Wang Jin Zhang Jie Cheng Yuan Ma Xiaomao Zou Huazheng Yang; We are grateful for financial support by the National Basic Research Program of China (973 Program)，the National Natural Science Foundation of China，the National Key Technologies R&D Program; A series of novel N-（4-（2-aryloxythiazol-5-yl）but-3-yn-2-yl）benzamide derivatives were designed and synthesized. Their structures were identified by IH NMR and elemental analyses. Preliminary bioassays indicated t...; 关键词：fungicides BENZAMIDE ACCASE aryloxythiazole herbicide

Microwave promoted synthesis of some N-(4-methyl-3-tolylthiazol-2(3H)-ylidene)substituted benzamides: 《Chinese Chemical Letters》2009年第9期1073-1076,共4页Aamer Saeed; N-（4-Methyl-3-tolylthiazol-2（3H）-ylidene） substituted benzamides （2a-o） were synthesized in good to excellent yields by the base-catalyzed direct cyclization of corresponding 1-tolyl-3-aryl thioureas （la-o） wi...; 关键词：2-Imino-l 3-thiazoline Green synthesis Microwave-accelerated

Relative efficacy of some prokinetic drugs in morphine-induced gastrointestinal transit delay in mice被引量：3: 《World Journal of Gastroenterology》2003年第4期779-783,共5页AD Suchitra SA Dkhar DG Shewade CH Shashindran; AIM:To study the relative efficacy of cisapride, metoclopramide,domperidone,erythromycin and mosapride on gastric emptying(GE)and small intestinal transit(SIT) in morphine treated mice. METHODS:Phenol red marker meal ...; 关键词：Animals BENZAMIDES CISAPRIDE Domperidone Drug Interactions Erythromycin Female Gastric Emptying Gastrointestinal Transit Male METOCLOPRAMIDE MICE MORPHINE Morpholines

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