Fapesp 2014/22827–7;Ministério da Saúde do Brasil;Fundação Faculdade de Medicina and CNPq Grant to JC:301275/2019–0.
Retroviruses have been proven to cause infections and diseases in a series of mammalian hosts but not in dogs.Then,this letter discussed the dog susceptibility to retrovirus infection,encompassing arguments to underst...
Endogenous retroviruses(ERVs)are viral elements that have been incorporated into the host genomes of mammals over time and have evolved to become part of the host genome.Some ERVs have been domesticated and serve a ro...
This study was supported by the National Natural Science Foundation of China(No.U1801681,to GC and No.31970906,to WL);Guangdong Science and Technology Department(‘Key technologies for treatment of brain disorders’,No.2018B030332001,to GC);the Natural Science Foundation of Guangdong Province of China(No.2020A1515011079,to WL and No.2020A1515010854,to QW);the internal funding from Jinan University(No.21616110,to GC);the Young Scientists Fund of the National Natural Science Foundation of China(No.31701291,to WL).
Regenerating functional new neurons in the adult mammalian central nervous system has been proven to be very challenging due to the inability of neurons to divide and repopulate themselves after neuronal loss.Glial ce...
Supported by National Natural Science Foundation of China(No.81470608)
Donor cornea shortage is a primary hurdle in the development of corneal transplantation. Of all species, porcine corneas are the ideal transplantation material for humans. However, the xenoimmune rejection induced by ...
Autophagy is a highly conserved pathway for physiological metabolism. Bilayer vesicles transport their contents to lysosomes for degradation. Autophagy is therefore a means of removing intracellular viruses and other ...
supported by grants from the National Natural Sciences Foundation of China(no.31470264,no.81271820,no.30870789 and no.30300117);the Key Program of the Natural Science Foundation of Hubei Province of China(no.2014CFA078);the Stanley Foundation from the Stanley Medical Research Institute(SMRI),USA(no.06R-1366),for Dr.F Zhu;the Scientific Innovation Team Project of Hubei Province of China(no.2015CFA009)
Human endogenous retrovirus W family(HERV-W) envelope(env) has been reported to be related to several human diseases, including autoimmune disorders, and it could activate innate immunity.However, there are no reports...
Supported by United States National Institutes of Health grant,No.R01AI070042
Retroviral replication proceeds through the integration of a DNA copy of the viral RNA genome into the host cellular genome, a process that is mediated by the viral integrase(IN) protein. IN catalyzes two distinct che...
Supported by Partially National Institutes of Health grants from NIAID(AI100682 to Grandgenett DP);NIGMS(GM109770 to Aihara H)
The retrovirus integrase(IN) is responsible for integration of the reverse transcribed linear c DNA into the host DNA genome. First, IN cleaves a dinucleotide from the 3' OH blunt ends of the viral DNA exposing the hi...
funded by the National Natural Science Foundation of China (31360597 and 31160493);the doctoral fund project of Ministry of Education (20111515110008);Inner Mongolia technology application research project (20130224)
Endogenous retroviruses(ERVs) are a component of the vertebrate genome and originate from exogenous infections of retroviruses in the germline of the host. ERVs have coevolved with their hosts over millions of years. ...
We attempted to improve the activity of hTERT promoter by fusing the vascular endothelial growth factor (VEGF) enhancer. To determine the potential as cancer specific promoters, we measured the reporter gene transfe...