RETROVIRUS

作品数:55被引量:89H指数:5
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相关领域:医药卫生生物学更多>>
相关作者:刘贇罗敏左祥生李纪平骆天红更多>>
相关机构:上海交通大学医学院附属瑞金医院中南大学广州中医药大学更多>>
相关期刊:《International Journal of Ophthalmology(English edition)》《Hepatobiliary & Pancreatic Diseases International》《Chinese Medical Journal》《Animal Diseases》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划广东省自然科学基金湖北省自然科学基金更多>>
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Are dogs not susceptible to retroviral infections?
《Animal Diseases》2024年第3期217-223,共7页Jorge Casseb João Henrique Campos Luciano Rodrigo Lopes 
Fapesp 2014/22827–7;Ministério da Saúde do Brasil;Fundação Faculdade de Medicina and CNPq Grant to JC:301275/2019–0.
Retroviruses have been proven to cause infections and diseases in a series of mammalian hosts but not in dogs.Then,this letter discussed the dog susceptibility to retrovirus infection,encompassing arguments to underst...
关键词:RETROVIRUS DOGS Endogenous retrovirus 
Awakening of ancient retrovirus:a new sign of aging in humans?
《Science China(Life Sciences)》2023年第6期1454-1455,共2页Yuliang Qu Jichang Wang 
Endogenous retroviruses(ERVs)are viral elements that have been incorporated into the host genomes of mammals over time and have evolved to become part of the host genome.Some ERVs have been domesticated and serve a ro...
关键词:ENDOGENOUS AGING 
Lineage tracing of direct astrocyte-to-neuron conversion in the mouse cortex被引量:10
《Neural Regeneration Research》2021年第4期750-756,共7页Zongqin Xiang Liang Xu Minhui Liu Qingsong Wang Wen Li Wenliang Lei Gong Chen 
This study was supported by the National Natural Science Foundation of China(No.U1801681,to GC and No.31970906,to WL);Guangdong Science and Technology Department(‘Key technologies for treatment of brain disorders’,No.2018B030332001,to GC);the Natural Science Foundation of Guangdong Province of China(No.2020A1515011079,to WL and No.2020A1515010854,to QW);the internal funding from Jinan University(No.21616110,to GC);the Young Scientists Fund of the National Natural Science Foundation of China(No.31701291,to WL).
Regenerating functional new neurons in the adult mammalian central nervous system has been proven to be very challenging due to the inability of neurons to divide and repopulate themselves after neuronal loss.Glial ce...
关键词:adeno-associated viruses ASTROCYTE dosage glia-to-neuron conversion in vivo reprogramming lineage tracing NEURON RETROVIRUS 
Reducing porcine corneal graft rejection, with an emphasis on porcine endogenous retrovirus transmission safety: a review
《International Journal of Ophthalmology(English edition)》2019年第2期324-332,共9页Yao-Wen Song Zhi-Qiang Pan 
Supported by National Natural Science Foundation of China(No.81470608)
Donor cornea shortage is a primary hurdle in the development of corneal transplantation. Of all species, porcine corneas are the ideal transplantation material for humans. However, the xenoimmune rejection induced by ...
关键词:corneal XENOTRANSPLANTATION genetically modified PIGS wild type PIGS costimulatory blockade drugs PORCINE endothelial GRAFTS PORCINE endogenous RETROVIRUS SAFETY 
Autophagy and virus infection被引量:3
《国际感染病学(电子版)》2017年第4期122-126,共5页Pingdong Jia 
Autophagy is a highly conserved pathway for physiological metabolism. Bilayer vesicles transport their contents to lysosomes for degradation. Autophagy is therefore a means of removing intracellular viruses and other ...
关键词:AUTOPHAGY VIRUS INFECTION RETROVIRUS 
Human leukemia antigen-A0201-restricted epitopes of humanendogenous retrovirus W family envelope(HERV-W env)inducestrong cytotoxic T lymphocyte responses被引量:4
《Virologica Sinica》2017年第4期280-289,共10页Xiaoning Tu Shan Li Lijuan Zhao Ran Xiao Xiuling Wang Fan Zhu 
supported by grants from the National Natural Sciences Foundation of China(no.31470264,no.81271820,no.30870789 and no.30300117);the Key Program of the Natural Science Foundation of Hubei Province of China(no.2014CFA078);the Stanley Foundation from the Stanley Medical Research Institute(SMRI),USA(no.06R-1366),for Dr.F Zhu;the Scientific Innovation Team Project of Hubei Province of China(no.2015CFA009)
Human endogenous retrovirus W family(HERV-W) envelope(env) has been reported to be related to several human diseases, including autoimmune disorders, and it could activate innate immunity.However, there are no reports...
关键词:HUMAN endogenous RETROVIRUS W (HERV-W) ENV peptide HLA CTL 
Retroviral integrase protein and intasome nucleoprotein complex structures被引量:2
《World Journal of Biological Chemistry》2017年第1期32-44,共13页Julia Grawenhoff Alan N Engelman 
Supported by United States National Institutes of Health grant,No.R01AI070042
Retroviral replication proceeds through the integration of a DNA copy of the viral RNA genome into the host cellular genome, a process that is mediated by the viral integrase(IN) protein. IN catalyzes two distinct che...
关键词:DNA integration 3-dimensional structure INTEGRASE Intasome Mouse mammary tumor virus RETROVIRUS Rous sarcoma virus Prototype foamy virus Human immunodeficiency virus/acquired immune deficiency syndrome 
Multifunctional facets of retrovirus integrase被引量:1
《World Journal of Biological Chemistry》2015年第3期83-94,共12页Duane P Grandgenett Krishan K Pandey Sibes Bera Hideki Aihara 
Supported by Partially National Institutes of Health grants from NIAID(AI100682 to Grandgenett DP);NIGMS(GM109770 to Aihara H)
The retrovirus integrase(IN) is responsible for integration of the reverse transcribed linear c DNA into the host DNA genome. First, IN cleaves a dinucleotide from the 3' OH blunt ends of the viral DNA exposing the hi...
关键词:RETROVIRUS INTEGRASE Integration HOST factors Atomic structure Human IMMUNODEFICIENCY virus INTEGRASE inhibitors 
Recent advances in the study of active endogenous retrovirus envelope glycoproteins in the mammalian placenta被引量:2
《Virologica Sinica》2015年第4期239-248,共10页Yufei Zhang Jing Shi Shuying Liu 
funded by the National Natural Science Foundation of China (31360597 and 31160493);the doctoral fund project of Ministry of Education (20111515110008);Inner Mongolia technology application research project (20130224)
Endogenous retroviruses(ERVs) are a component of the vertebrate genome and originate from exogenous infections of retroviruses in the germline of the host. ERVs have coevolved with their hosts over millions of years. ...
关键词:ENVELOPE GLYCOPROTEIN ENDOGENOUS RETROVIRUS placen 
Increased Activity of the Human Telomerase Catalytic Subunit Promoter by the VEGF Enhancer in Human Cancer Cells
《International Journal of Technology Management》2014年第9期140-142,共3页Huwei1 Mengxingyu Tianyuhua Zangyujing Hurui 
We attempted to improve the activity of hTERT promoter by fusing the vascular endothelial growth factor (VEGF) enhancer. To determine the potential as cancer specific promoters, we measured the reporter gene transfe...
关键词:hTERT promoter VEGF enhancer RETROVIRUS targeted cancer gene therapy 
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