Autophagy and virus infection  

作　　者：Pingdong Jia 

机构地区：[1]Department of Respiratory Medicine, Jinan Central Hospital, Jinan 250013, China

出　　处：《国际感染病学（电子版）》2017年第4期122-126,共5页Infection International(Electronic Edition)

摘　　要：Autophagy is a highly conserved pathway for physiological metabolism. Bilayer vesicles transport their contents to lysosomes for degradation. Autophagy is therefore a means of removing intracellular viruses and other pathogens in mammalian cells. However, the role of autophagy in virus infection is complex. Several viruses have developed a way to escape autophagy-dependent degradation and replicate themselves through autophagy. This paper summarizes the fundamental mechanism and function of autophagy and its role in infection with viruses such as human immunodeficiency virus, T-cell leukemia virus type 1, and other retroviruses.Autophagy is a highly conserved pathway for physiological metabolism. Bilayer vesicles transport their contents to lysosomes for degradation. Autophagy is therefore a means of removing intracellular viruses and other pathogens in mammalian cells. However, the role of autophagy in virus infection is complex. Several viruses have developed a way to escape autophagy-dependent degradation and replicate themselves through autophagy. This paper summarizes the fundamental mechanism and function of autophagy and its role in infection with viruses such as human immunodeficiency virus, T-cell leukemia virus type 1, and other retroviruses.

关 键 词：AUTOPHAGY VIRUS INFECTION RETROVIRUS 

分 类 号：R511[医药卫生—内科学]