INTEGRASE

作品数：42被引量：87H指数：5
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相关领域：医药卫生生物学更多>>
相关作者：刘洋韩婧婉李林贾磊王晓林更多>>
相关机构：北京工业大学北京化工大学中国医学科学院军事医学科学院更多>>
相关期刊：《Science China(Life Sciences)》《Open Journal of Medical Microbiology》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金中国博士后科学基金更多>>
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The differential effects of integrase strand transfer inhibitors and efavirenz on neuropsychiatric conditions and brain imaging in HIV-positive men who have sex with men被引量：2
《Biosafety and Health》2024年第4期216-224,共9页Yihui He Yang Zhang Jiaxin Zhen Guangqiang Sun Zhen Li Bo Yang Bin Yang Keyi Chang Xue Chen Yulin Zhang Caiping Guo Wen Wang Ping Wu Tong Zhang Lei Wang 
supported by the National Natural Science Foundation of China(82072271,82241072,82072294);the National Key Research and Development Program of China(2021YFC2501402,2021YFC0122601);the Beijing Natural Science Foundation(7222095,7222091);the Peak Talent Program of Beijing Hospital Authority(DFL20191701);the Capital’s Funds for Health Improvement and Research(2022-1-1151);the Research and Translational Application of Clinical Characteristic Diagnostic and Treatment Techniques in Capital City(Z221100007422055);the Beijing Research Center for Respiratory Infectious Diseases(BJRID2024-001);the Beijing Hospitals Authority Innovation Studio of Young Staff Funding Support(2021037);the High-level Public Health Technical Personnel Construction Project(2022-1-007);the High-level Public Health Specialized Talents Project of Beijing Municipal Health commission(2022-02-20);the Beijing Key Laboratory for HIV/AIDS Research(BZ0089).
Integrase strand transfer inhibitors(INSTIs)have emerged as the first‐line choice for treating human immunodeficiency virus(HIV)infection due to their superior efficacy and safety.However,the impact of INSTIs on the ...
关键词：Human immunodeficiency virus(HIV) Multimodal magnetic resonance imaging(MRI) Integrase strand transfer inhibitors(INSTIs) Efavirenz(EFV) 
Engineering CRISPR for emerging therapeutic applications
《EngMedicine》2024年第3期10-20,共11页Xiaoqi Sun Zhuang Liu 
supported by the New Cornerstone Science Foundation through the New Cornerstone Investigator Program and the XPLORER PRIZE,the National Research Program of China(2021YFF0701800 and 2020YFA0211100);the National Natural Science Foundation of China(T2321005 and 52032008);the Collaborative Innovation Center of Suzhou Nano Science and Technology,and the 111 Program of the Ministry of Education of China.
Clustered regularly interspaced short palindromic repeats(CRISPRs)were originally identified in bacterial and archaeal genomes as an adaptive immune response against invading viruses and phages.The discovery of the ab...
关键词：CRISPR Base editing Prime editing CRISPR-directed integrase Epigenetic editing RNA editing 
Pretreatment integrase strand transfer inhibitor resistance in Tianjin,China
《Chinese Medical Journal》2023年第22期2735-2737,共3页Huan Xia Zhangwen Ge Defa Zhang Yue Wu Ping Ma 
supported by grants from the National Natural Science Foundation of China(Nos.82002136 and 82260658);the Health Science and Technology Project of Tianjin Health Commission(Nos.TJWJ2021MS033,ZC20037);the Tianjin Key Medical Discipline(Specialty)Construction Project(No.TJYXZDXK-059B);the National Major Scientific and Technological Special Project during the Thirteenth Five-year Plan Period(Grant No.2018ZX10302104);the Science and Technology Project of Guizhou Province(qian ke he foundation-ZK[2023]general 215)
Human immunodeficiency virus(HIV)infection is a significant and pressing concern for public health worldwide.[1]Midway through the 1990s,the widespread use of antiretroviral therapy(ART)has resulted in a significant p...
关键词：INFECTION MORTALITY prognosis 
Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression被引量：5
《Science China(Life Sciences)》2022年第11期2269-2286,共18页Qin Jin Xiaoyu Yang Shixue Gou Xiaoyi Liu Zhenpeng Zhuang Yanhui Liang Hui Shi Jiayuan Huang Han Wu Yu Zhao Zhen Ouyang Quanjun Zhang Zhaoming Liu Fangbing Chen Weikai Ge Jingke Xie Nan Li Chengdan Lai Xiaozhu Zhao Jiaowei Wang Meng Lian Lei Li Longquan Quan Yinghua Ye Liangxue Lai Kepin Wang 
the National Key Research and Development Program of China(2017YFA0105103,2021YFA0805903);the National Natural Science Foundation of China(81941004,32170542);2020 Research Program of Sanya Yazhou Bay Science and Technology City(202002011);Major Science and Technology Projects of Hainan Province(ZDKJ2021030);Key Research&Development Program of Hainan Province(ZDYF2021SHFZ052);Youth Innovation Promotion Association of the Chinese Academy of Sciences(2019347);Young Elite Scientist Sponsorship Program by CAST(YESS20200024);Biological Resources Progaramme,Chinese Academy of Sciences(KFJBRP-017-57);Key Research&Development Program of Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory)(2018GZR110104004);China Postdoctoral Science Foundation(2020M682943);Science and Technology Planning Project of Guangdong Province,China(2019A030317010,2020B1212060052,2021B1212040016,2021A1515011110);Science and Technology Program of Guangzhou,China(202007030003);Research Unit of Generation of Large Animal Disease Models,Chinese Academy of Medical Sciences(2019-I2M-5-025)。
Inducible expression systems are indispensable for precise regulation and in-depth analysis of biological process.Binary Tet-On system has been widely employed to regulate transgenic expression by doxycycline.Previous...
关键词：double knock-in Tet-On system phiC31-mediated cassette exchange pig model hKRASG12D-related tumorigenesis 
Multiplexed site-specific genome engineering in Mycolicibacterium neoaurum by Att/Int system
《Synthetic and Systems Biotechnology》2022年第3期1002-1011,共10页Ke Liu Gui-Hong Lin Kun Liu Yong-Jun Liu Xin-Yi Tao Bei Gao Ming Zhao Dong-Zhi Wei Feng-Qing Wang 
supported by the National Natural Science Foundation of China(No.21776075);the Natural Science Foundation of Shanghai(No.20ZR1415100);the National Key Research and Development Program of China(No.SQ2020YFC210061).
Genomic integration of genes and pathway-sized DNA cassettes is often an indispensable way to construct robust and productive microbial cell factories.For some uncommon microbial hosts,such as Mycolicibacterium and My...
关键词：Site-specific recombination Phage integrase Xer recombinases Mycolicibacterium Multi-copy integration 
An inducible constitutive expression system in Bombyx mori mediated by phiC31 integrase被引量：1
《Insect Science》2021年第5期1277-1289,共13页Feng Wang Yan-Ting Ji Chi Tian Yuan-Cheng Wang Shen Xu Ri-Yuan Wang Qian-Qian Yang Ping Zhao Qing-You Xia 
the National Natural Science Foundation of China(31530071);Chongqing Science and Technology C ommission(CSTC2018JCYJAX0298);Fundamental Research Funds for the Central Universities(XDJK2018C064);State Key Laboratory of Silkworm Genome Biology(SKLSGB1819-1).
Inducible gene-expression systems play important roles in gene functional assays in the post-genome era.Streptomyces phage-derived phiC31 integrase,which mediates an irreversible site-specific cassette exchange betwee...
关键词：inducible gene expression PhiC31 integrase promoter flipping SILKWORM 
Petroleum exploitation enriches the sulfonamide resistance gene sul2 in off shore sediments
《Journal of Oceanology and Limnology》2021年第3期946-954,共9页Jing WANG Jiti ZHOU 
Antibiotic resistance genes(ARGs)have been considered as emerging contaminants in nature owing to their wide distribution and human health risk.Anthropogenic activities can increase the diversity and abundance of ARGs...
关键词：petroleum exploitation sulfonamide resistance gene quantitative real-time PCR offshore sediment Class 1 integrase 
Suppression of HIV-1 Integration by Targeting HIV-1 Integrase for Degradation with A Chimeric Ubiquitin Ligase
《Virologica Sinica》2021年第3期424-437,共14页Zuopeng Zhang Sen Yuan Shuting Xu Deyin Guo Lang Chen Wei Hou Min Wang 
supported by Grants from the National Science and Technology Major Project of China (2014ZX10001003);National Natural Science Foundation of China (#81620108020 & #31400774)。
Human immunodeficiency virus(HIV) attacks human immune system and causes life-threatening acquired immune deficiency syndrome(AIDS). Treatment with combination antiretroviral therapy(cART) could inhibit virus growth a...
关键词：HIV-1 INTEGRASE Iduna LEDGF Chimeric E3s UBIQUITINATION 
Application of serine integrases for secondary metabolite pathway assembly in Streptomyces被引量：3
《Synthetic and Systems Biotechnology》2020年第2期111-119,共9页Hong Gao Gabrielle Taylor Stephanie K.Evans Paul C.M.Fogg Margaret C.M.Smith 
This work was supported by the Biotechnology and Biological Sciences Research Council project grant BB/K003356/1.HPLC-MS analysis was performed on equipment within the Centre of Excellence in Mass Spectrometry(University of York),funded by Science City York(Yorkshire Forward,EP/K039660/1,EP/M028127/1).
Serine integrases have been shown to be efficient tools for metabolic pathway assembly.To further improve the flexibility and efficiency of pathway engineering via serine integrases,we explored how multiple orthogonal...
关键词：Serine integrase Pathway assembly STREPTOMYCES ERYTHROMYCIN 
Multidrug Resistant <i>Shigella</i>Associated with Class 1 Integrase and Other Virulence Genes as a Cause of Diarrhea in Pediatric Patients被引量：1
《Open Journal of Medical Microbiology》2020年第1期1-16,共16页Samah Sabry El-Kazzaz Ghada El-Saeed Mashaly Mayada S. Zeid 
Background: Shigella is one of the most serious pathogens associated with bloody diarrhea in children. The empiric antibiotic therapy of enteric illness with blood streaked stool leads to emergence of multi drug resis...
关键词：MDR SHIGELLA INTEGRASE DIARRHEA 
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