NUCLEOCAPSID

作品数:26被引量:32H指数:4
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相关领域:农业科学更多>>
相关作者:王先炜李玉峰姜平欧阳志荃龙钢更多>>
相关机构:中国科学院研究生院中国科学院南京农业大学更多>>
相关期刊:《Chinese Medical Journal》《Signal Transduction and Targeted Therapy》《Agricultural Biotechnology》《High Technology Letters》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划国家科技支撑计划国家科技重大专项更多>>
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Cryo-EM structure of the nucleocapsid-like assembly of respiratory syncytial virus
《Signal Transduction and Targeted Therapy》2023年第9期4394-4402,共9页Yan Wang Chong Zhang Yongbo Luo Xiaobin Ling Bingnan Luo Guowen Jia Dan Su Haohao Dong Zhaoming Su 
This research was supported by Ministry of Science and Technology of China(MoST 2022YFC2303700 and 2021YFA1301900);National Natural Science Foundation of China(NSFC 32222040 and 32070049);Tianjin Synthetic Biotechnology Innovation Capacity Improvement Action(TSBICIP-KJGG-008);the 1.3.5 Project for Disciplines Excellence of West China Hospital,Sichuan University(ZYYC21006)to Z.S.The pCAG-OSF vector plasmid was a kind gift from Prof.Jinbiao Ma at Fudan University。
Respiratory syncytial virus(RSV)is a nonsegmented,negative strand RNA virus that has caused severe lower respiratory tract infections of high mortality rates in infants and the elderly,yet no effective vaccine or anti...
关键词:RESPIRATORY VACCINE STRUCTURE 
Spike-and nucleocapsid-based gold colloid assay toward the development of an adhesive bandage for rapid SARS-CoV-2 immune response detection and screening
《Microsystems & Nanoengineering》2023年第3期371-386,共16页Imen Boumar Muhammedin Deliorman Pavithra Sukumar Mohammad A.Qasaimeh 
This work was financially supported by the NYUAD COVID-19 Facilitator Research Fund from NYU Abu Dhabi,UAE.The authors acknowledge the donors and nurses for their contributions to blood donation and collection.Additionally,the authors acknowledge the technical support from the Core Technology Platforms at NYU Abu Dhabi,especially the help of Mr.Vijay Dhanvi and Mr.Jinumon Govindan.The authors also thank Dr.Ayoub Glia for the discussions.
Immunoglobulin M(IgM)and immunoglobulin G(IgG)antibodies are important biomarkers used for the diagnosis and screening of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infections in both symptomatic and a...
关键词:diagnosis utilize selecting 
Predictors of anti-SARS-CoV-2 seropositivity:An Egyptian population-based study
《Infectious Medicine》2022年第2期113-123,共11页Engy Mohamed El-Ghitany Ayat Ashour Azza Galal Farghaly Mona H.Hashish Eman A.Omran 
supported financially by the Science and Technology Development Fund(STDF),Egypt;Project No.43834.
Background:Population-based studies on the determinants of COVID-19 seroprevalence constitute a cornerstone in guiding appropriate preventive measures.Such studies are scarce in Egypt,thus we conducted this study to e...
关键词:COVID-19 PREDICTORS SEROPREVALENCE Anti-spike Anti-nucleocapsid 
The two-stage interaction of Ebola virus VP40 with nucleoprotein results in a switch from viral RNA synthesis to virion assembly/ budding
《Protein & Cell》2022年第2期120-140,共21页Linjuan Wu Dongning Jin Dan Wang Xuping Jing Peng Gong Yali Qin Mingzhou Chen 
We acknowledge Dr.Bo Zhang(Wuhan Institute of Virology)and Dr.Heinz Feldmann(National Institutes of Health,Hamilton,Montana,USA)for providing the Ebola cDNA and minigenome assay system,respectively;This research is supported by grants from the National Natural Science Foundation of China(81825015);National Key R&D Program of China(2017YFA0505801);National Science and Technology Major Project(2018ZX10101004);National Natural Science Foundation of China(81871650 and 31630086);The Natural Science Foundation of Hubei Province Innovation Group(2017CFA022);Advanced Customer Cultivation Project of Wuhan National Biosafety Laboratory(2019ACCP-MS06).
Ebola virus(EBOV)is an enveloped negative-sense RNA virus and a member of the filovirus family.Nucleoprotein(NP)expression alone leads to the formation of inclusion bodies(IBs),which are critical for viral RNA synthes...
关键词:Ebola virus NUCLEOPROTEIN matrix protein two-stage interaction RNA synthesis NUCLEOCAPSID assembly/budding 
A novel phosphorylation site in SARS-CoV-2 nucleocapsid regulates its RNA-binding capacity and phase separation in host cells
《Journal of Molecular Cell Biology》2022年第2期72-75,共4页Junyu Wu Yongheng Zhong Xue Liu Xiaoyu Lu Weijie Zeng Chunyan Wu Fan Xing Liu Cao Fuxiang Zheng Panpan Hou Hong Peng Chunmei Li Deyin Guo 
supported by the National Natural Science Foundation of China(32041002 to D.G.and 31800151 to J.W.);Guangdong Province‘Pearl River Talent Plan’Innovation and Entrepreneurship Team Project(2019ZT08Y464 to C.L.);Shenzhen Science and Technology Program(JSGG20200225150431472 and KQTD20180411143323605 to D.G.,GXWD20201231165807008 and 20200825183117001 to J.W.).
Dear Editor,The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a novel emerging coronavirus that has spread worldwide since breaking out in late 2019 and has led to hundreds of millions of infections an...
关键词:ACUTE RESPIRATORY 
Clinical significance of anti-nucleocapsid-IgG sero-positivity in SARS-CoV-2 infection in hospitalized patients in North Dakota
《World Journal of Clinical Infectious Diseases》2022年第2期50-60,共11页Bakir Dzananovic Mark Williamson Casmiar Nwaigwe Chittaranjan Routray 
the National Institute of General Medical Sciences of the National Institutes of Health under Award,No.U54GM128729.
BACKGROUND During the peak of the coronavirus diseases 2019(COVID-19)pandemic,clinicians actively studied the utility of various epidemiologic-clinical parameters to determine the prognosis for patients hospitalized w...
关键词:COVID-19 SARS-CoV-2 IgG-N Anti-nucleocapsid IgG CYTOKINES 
不同染色条件对COVID-19 Nucleocapsid抗体免疫组化染色的比较被引量:2
《临床与实验病理学杂志》2021年第11期1277-1280,共4页吉佳乐 林爽 曾晖 姚馨悦 李杨 何志承 
新冠肺炎防控应急科研专项(2020NCPZX01)。
目的探讨新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)Nucleocapsid抗体在不同平台、不同操作条件下的染色情况,筛选该抗体的最佳染色条件,为COVID-19的病理诊断和临床治疗提供参考。方法将8例COVID-19尸检肺组织石蜡样本制成...
关键词:COVID-19 免疫组织化学 染色条件 
Autographa Californica Multiple Nucleopolyhedrovirus orf13 Is Required for Efficient Nuclear Egress of Nucleocapsids
《Virologica Sinica》2021年第5期968-980,共13页Xingang Chen Xiaoqin Yang Chengfeng Lei Fujun Qin Xiulian Sun Jia Hu 
supported by the National Key Research and Development Program of China(2017YFD0201206);the WIV “One-Three-Five”strategic program(Y602111SA1 to XS)。
Autographa californica multiple nucleopolyhedrovirus(Ac MNPV)orf13(ac13)is a conserved gene in all sequenced alphabaculoviruses.However,its function in the viral life cycle remains unknown.In this study,we found that ...
关键词:Autographa californica multiple nucleopolyhedrovirus(AcMNPV) orf13 Nucleocapsid egress OB morphogenesis 
Real-time reverse transcription-polymerase chain reaction assay panel for the detection of severe acute respiratory syndrome coronavirus 2 and its variants被引量:4
《Chinese Medical Journal》2021年第17期2048-2053,共6页Rou-Jian Lu Li Zhao Bao-Ying Huang Fei Ye Wen-Ling Wang Wen-Jie Tan 
This work was supported by grants from the National Key Research and Development Program of China(Nos.2016YFD0500301,2021YFC0863300,and 2020YFC0840900).
Background:With the ongoing worldwide coronavirus disease 2019(COVID-19)pandemic,an increasing number of viral variants are being identified,which poses a challenge for nucleic acid-based diagnostic tests.Rapid tests,...
关键词:COVID-19 SARS-CoV-2 RT-PCR assay Variants of concern RNA polymerase NUCLEOCAPSID SARS-CoV-2 B.1.351 SARS-CoV-2 B.1.1.7 SARS-CoV-220A S484K variant 
Development of two TaqMan real-time reverse transcription-PCR assays for the detection of severe acute respiratory syndrome coronavirus-2被引量:4
《Biosafety and Health》2020年第4期232-237,共6页Yiwei Liu Yingying Wang Xinming Wang Yan Xiao Lan Chen Li Guo Jianguo Li Lili Ren Jianwei Wang 
funded in part by the Project from the Ministry of Science and Technology in China(2020YFC0841200);the National Major Science&Technology Project for Control and Prevention of Major Infectious Diseases in China(2017ZX10103004);the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(2020HY320001);the non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2019PT310029);the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(2016-I2M-1-014).
The outbreak of coronavirus disease 2019(COVID-19)in Wuhan,China,was caused by a novel coronavirus(CoV),named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The rapid detection of viral nucleic acids is c...
关键词:SARS-CoV-2 Real-time RT-PCR NUCLEOCAPSID Open reading frame 1b 
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