OXYSTEROLS

作品数：8被引量：22H指数：3
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相关领域：医药卫生更多>>
相关作者：和欣王维义华茜更多>>
相关机构：北京中医药大学新加坡国立大学更多>>
相关期刊：《Neuroscience Bulletin》《Journal of Biosciences and Medicines》《Neural Regeneration Research》《Liver Research》更多>>
相关基金：国家自然科学基金更多>>
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Cytotoxicity of Cholesterol Oxides and the Consequences of Relative Molecular Similarity to cGMP Nucleotide
《Journal of Biosciences and Medicines》2023年第11期190-207,共18页Wynford Robert Williams 
Cholesterol and cholesterol oxides impact on the functional properties of cells, in respect of the intracellular and extracellular distribution of compounds across cell membranes, carcinogenesis and drug resistance. A...
关键词：Cholesterol Oxides CGMP OXYSTEROLS Molecular Similarity Apoptosis AUTOPHAGY Cancer 
Neurosteroids as stress modulators and neurotherapeutics: lessons from the retina被引量：1
《Neural Regeneration Research》2023年第5期1004-1008,共5页Yukitoshi Izumi Makoto Ishikawa Toru Nakazawa Hiroshi Kunikata Kota Sato Douglas F.Covey Charles F.Zorumski 
supported by MH101874, MH114866, MH122379 from the National Institute of Mental Health (to CFZ);the Taylor Family Institute for Innovative Psychiatric Research and the Bantly Foundation (to CFZ)。
Neurosteroids are rapidly emerging as important new therapies in neuropsychiatry, with one such agent, brexanolone, already approved for treatment of postpartum depression, and others on the horizon. These steroids ha...
关键词：ALLOPREGNANOLONE autophagy ENANTIOMERS EXCITOTOXICITY gamma-aminobutyric acid type A receptors glaucoma optic nerve OXYSTEROLS 
Oxysterols as promising small molecules for bone tissue engineering: Systematic review被引量：1
《World Journal of Orthopedics》2020年第7期328-344,共17页Ethan Cottrill Julianna Lazzari Zach Pennington Jeff Ehresman Andrew Schilling Naomi Dirckx Nicholas Theodore Daniel Sciubba Timothy Witham 
BACKGROUND Bone tissue engineering is an area of continued interest within orthopaedic surgery,as it promises to create implantable bone substitute materials that obviate the need for autologous bone graft.Recently,ox...
关键词：OXYSTEROL Bone tissue engineering Critical-sized defect Biomaterial Orthopaedic surgery Systematic review 
The acidic pathway of bile acid synthesis: Not just an alternative pathway被引量：7
《Liver Research》2019年第2期88-98,共11页William M.Pandak Genta Kakiyama 
This work was supported by Gilead Sciences Liver Research Award 2016 and Virginia Commonwealth University DOIM Pilot Project Grant(4111393)to G.Kakiyama;Veterans Administration Merit Award I01 BX000197-07 to W.M.Pandak.
Over the last two decades,the prevalence of obesity,and metabolic syndromes(MS)such as nonalcoholic fatty liver disease(NAFLD)and type 2 diabetes mellitus(T2DM),have dramatically increased.Bile acids play a major role...
关键词：Bile acids Metabolic syndromes(MS) Cardiovascular disease(CVD) INFLAMMATION Insulin resistance OXYSTEROLS 
Oligomerized Amyloid-<i>β</i><sub>1-40</sub>Peptide Favors Cholesterol, Oxysterol, and Fatty Acid Accumulation in Human Neuronal SK-N-BE Cells
《International Journal of Clinical Medicine》2015年第11期813-824,共12页Amira Zarrouk Thomas Nury Mohamed Hammami Gérard Lizard 
Amyloid peptide, the main component of senile plaques, is a major biological characteristic of Alzheimer’s disease (AD). The aim of the present study conducted on human neuronal SK-N-BE cells was to evaluate whether ...
关键词：SK-N-BE CELLS Oligomerized Aβ1-40 CHOLESTEROL OXYSTEROLS Very Long Chain Fatty Acids 
New insights into the regulation of cholesterol eft from the sperm membrane被引量：5
《Asian Journal of Andrology》2015年第4期561-567,共7页Tamara Leahy Bart M Gadella 
Cholesterol is an essential component of the mammalian plasma membrane because it promotes membrane stability without comprising membrane fluidity. Given this important cellular role, cholesterol levels are tightly co...
关键词：ATP binding cassette transporters ALBUMIN high-density lipoprotein lipid rafts membrane fluidity membranemicrodomains membrane packing OXYSTEROLS reverse cholesterol transport sterol transporters 
The Involvement of Lipids in Alzheimer's Disease被引量：6
《Journal of Genetics and Genomics》2014年第5期261-274,共14页Wei Ling Florence Lim Ian James Martins Ralph Nigel Martins 
Wei Ling Florence Lim and Ian J. Martins are supported by National Health and Medical Research Council (NHMRC) grant of Australia;Ralph N. Martins is supported by grants from McCusker Alzheimer’s Disease Research Foundation and NHMRC
It has been estimated that Alzheimer＇s disease （AD）, the most common form of dementia, will affect approximately 81 million individuals by 2040. To date, the actual cause and cascade of events in the progression of...
关键词：Alzheimer＇s disease LIPIDS APOE OXYSTEROLS INFLAMMATION 
Distribution of cholesterol 24-hydroxylase in the monkey brain被引量：2
《Neuroscience Bulletin》2010年第3期197-204,共8页和欣 王维义 华茜 
supported by the National Natural Science Foundation of China(No.30901940);the Scientific Research Foundation for the Returned Overseas Chinese Scholars,Education Ministry of China
Objective Cholesterol 24-hydroxylase catalyzes the conversion of cholesterol to 24-hydroxycholesterol,which is a major pathway for cholesterol elimination from the brain,since 24-hydroxycholesterol can readily cross t...
关键词：AXON CHOLESTEROL cholesterol 24-hydroxylase OXYSTEROLS 
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