OXYSTEROL

作品数：5被引量：3H指数：1
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相关期刊：《Acta Pharmacologica Sinica》《Science Bulletin》《Cell Research》《World Journal of Orthopedics》更多>>
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ABT-199 inhibits Hedgehog pathway by acting as a competitive inhibitor of oxysterol,rather as a BH3 mimetic被引量：1
《Acta Pharmacologica Sinica》2021年第6期1005-1013,共9页Juan Wang Yu Zhang Wen-jing Huang Jun Yang Wei-guo Tang Tao-min Huang Wen-fu Tan 
This work was financially supported by grants from National Natural Science Foundation of China(No.81773767,81573452);We also appreciate Fudan-SIMM Joint Research Fund(No.FU-SIMM20181005);MHHFDU-SPFDU Joint Research Fund(No.RO-MY201805);the fund from State Key Laboratory of Drug Research(No SIMM1903KF-12).
Aberrantly activated Hedgehog(Hh)pathway is critical for driving the initiation and progression of multiple types of cancers,including medulloblastoma(MB)and basal cellular carcinoma(BCC).The majority of current Hh an...
关键词：Hedgehog SMOOTHENED cysteine rich domain MEDULLOBLASTOMA basal cellular carcinoma 
Oxysterols as promising small molecules for bone tissue engineering: Systematic review被引量：1
《World Journal of Orthopedics》2020年第7期328-344,共17页Ethan Cottrill Julianna Lazzari Zach Pennington Jeff Ehresman Andrew Schilling Naomi Dirckx Nicholas Theodore Daniel Sciubba Timothy Witham 
BACKGROUND Bone tissue engineering is an area of continued interest within orthopaedic surgery,as it promises to create implantable bone substitute materials that obviate the need for autologous bone graft.Recently,ox...
关键词：OXYSTEROL Bone tissue engineering Critical-sized defect Biomaterial Orthopaedic surgery Systematic review 
Oligomerized Amyloid-<i>β</i><sub>1-40</sub>Peptide Favors Cholesterol, Oxysterol, and Fatty Acid Accumulation in Human Neuronal SK-N-BE Cells
《International Journal of Clinical Medicine》2015年第11期813-824,共12页Amira Zarrouk Thomas Nury Mohamed Hammami Gérard Lizard 
Amyloid peptide, the main component of senile plaques, is a major biological characteristic of Alzheimer’s disease (AD). The aim of the present study conducted on human neuronal SK-N-BE cells was to evaluate whether ...
关键词：SK-N-BE CELLS Oligomerized Aβ1-40 CHOLESTEROL OXYSTEROLS Very Long Chain Fatty Acids 
New wrestling rules of anti-inflammatory transrepression by oxysterol receptor LXR revealed被引量：1
《Cell Research》2011年第5期711-714,共4页Eckardt Treuter 
While nuclear receptors （NRs） generally function as transcriptional regulators of diverse metabolic, developmental and proliferative processes, some NRs also appear to modulate inflammatory processes such as those d...
关键词：核受体 Toll样受体 显示 消炎 自然保护区 免疫系统 细胞信号 巨噬细胞 
Syntheses of oxysterol receptors'(LXRs) ligands
《Chinese Science Bulletin》2003年第3期247-254,共8页ZHOU Xiangdong ZHEN Hui ZHOU Weishan 
supported by the National Natural Science Foundation of China(Grant No.20072047);the State Key Laboratory of Biological Organic Chemistry in Shanghai Institute of Organic Chemistry,Chongqing Science and Technology Committee(Grant No.6617);the Third Military Medical University.
The LXRs?agonist, 24S,25-epoxycholesterol 1,was synthesized stereoselectively (100% d.e.) in 56% overall yield from methyl hyodeoxycholanate 4 in 9 steps with des-mosterol acetate 11 as the key intermediate and the mo...
关键词：methyl hyodeoxycholanate desmosterol acetate 24S 25-epoxycholesterol sharpless catalytic asymmetric dihydoxylation LXRs'agonists. 
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