Targeting gut microbiota and its associated metabolites as a potential strategy for promoting would healing in diabetes  

作　　者：Ling Xiong Ya-Xin Huang Lan Mao Yong Xu Yong-Qiong Deng 

机构地区：[1]Department of Dermatology&STD,The Affiliated Hospital of Southwest Medical University,Luzhou 646000,Sichuan Province,China [2]Department of Endocrinology and Metabolism,The Affiliated Hospital of Southwest Medical University,Luzhou 646000,Sichuan Province,China [3]Department of Dermatology&STD,Chengdu Integrated TCM&Western Medicine Hospital,Chengdu 610000,Sichuan Province,China [4]Institute of Cardiovascular Research,Southwest Medical University,Luzhou 646000,Sichuan Province,China

出　　处：《World Journal of Diabetes》2025年第5期16-30,共15页世界糖尿病杂志(英文)

基　　金：Supported by Sichuan Provincial Department of Science and Technology Youth Fund Project,No.2024NSFSC1609;Sichuan Province Postdoctoral Special Funding Project,No.TB2023046。

摘　　要：Impaired healing of diabetic wounds is one of the most important complications of diabetes,often leading to lower limb amputations and incurring significant economic and psychosocial costs.Unfortunately,there are currently no effective prevention or treatment strategies available.Recent research has reported that an imbalance in the gut microbiota,known as dysbiosis,was linked to the onset of type 2 diabetes,as well as the development and progression of diabetic complications.Indeed,the gut microbiota has emerged as a promising therapeutic approach for treating type 2 diabetes and related diseases.However,there is few of literatures specifically discussing the relationship between gut microbiota and diabetic wounds.This review aims to explore the potential role of the gut microbiota,especially probiotics,and its associated byproducts such as short chain fatty acids,bile acids,hydrogen sulfide,and tryptophan metabolites on wound healing to provide fresh insights and novel perspectives for the treatment of chronic wounds in diabetes.

关 键 词：Type 2 diabetes Wound healing Gut microbiota Short chain fatty acids TRYPTOPHAN Bile acids Hydrogen sulfide 

分 类 号：R587.1[医药卫生—内分泌]